| Cell line name |
MRO |
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| Synonyms |
MRO-87-1; MRO 87-1; MRO-87; MRO87-1; MRO87; RO 87-M-1 |
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| Accession |
CVCL_6310 |
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| Resource Identification Initiative |
To cite this cell line use: MRO (RRID:CVCL_6310) |
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| Comments |
Problematic cell line: Contaminated. Shown to be a HT-29 derivative (PubMed=18713817; PubMed=20143388). Originally thought to originate from a thyroid gland follicular carcinoma.
From: Juillard G.J.-F.; University of California, Los Angeles; Los Angeles; USA.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00240.
Population: Caucasian.
Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
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| Sequence variations |
- Mutation; HGNC; 583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
|
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| Disease |
Colon adenocarcinoma (NCIt: C4349) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0320 (HT-29) |
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| Sex of cell |
Female |
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| Age at sampling |
44Y |
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| Category |
Cancer cell line |
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| STR profile |
Source(s): PubMed=18713817
Markers:
Run an STR similarity search on this cell line |
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| Web pages |
https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx |
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| Publications | PubMed=2551628; DOI=10.1210/endo-125-4-1783
Pang X.-P., Hershman J.M., Chung M., Pekary A.E.
Characterization of tumor necrosis factor-alpha receptors in human and rat thyroid cells and regulation of the receptors by thyrotropin.
Endocrinology 125:1783-1788(1989) PubMed=18713817; DOI=10.1210/jc.2008-1102
Schweppe R.E., Klopper J.P., Korch C.T., Pugazhenthi U., Benezra M., Knauf J.A., Fagin J.A., Marlow L.A., Copland J.A. III, Smallridge R.C., Haugen B.R.
Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification.
J. Clin. Endocrinol. Metab. 93:4331-4341(2008) PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_6310
|
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| Biological sample resources |
BioSample; SAMN03151794
|
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| Encyclopedic resources |
Wikidata; Q54906742
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| Polymorphism and mutation databases |
Cosmic; 886553
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| Entry history |
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| Entry creation | 04-Apr-2012 |
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| Last entry update | 05-Oct-2023 |
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| Version number | 25 |
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