| Cell line name |
KM20L2 |
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| Synonyms |
KM-20L2; KM 20L2; KM 2012 |
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| Accession |
CVCL_D889 |
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| Resource Identification Initiative |
To cite this cell line use: KM20L2 (RRID:CVCL_D889) |
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| Comments |
Problematic cell line: Contaminated. Shown to be a HT-29 derivative (PubMed=15703300; resulting in a decision not to include the cell line in the NCI60 panel).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00514.
Misspelling: KM202L; Note=Occasionally. |
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| Sequence variations |
- Mutation; HGNC; 583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
|
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| Disease |
Colon adenocarcinoma (NCIt: C4349) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0320 (HT-29) |
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| Sex of cell |
Female |
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| Age at sampling |
44Y |
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| Category |
Cancer cell line |
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| Web pages |
https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx
https://dtp.cancer.gov/discovery_development/nci-60/cell_list.htm |
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| Publications | PubMed=3349467
Morikawa K., Walker S.M., Jessup J.M., Fidler I.J.
In vivo selection of highly metastatic cells from surgical specimens of different primary human colon carcinomas implanted into nude mice.
Cancer Res. 48:1943-1948(1988) PubMed=2041050; DOI=10.1093/jnci/83.11.757
Monks A., Scudiero D.A., Skehan P., Shoemaker R.H., Paull K.D., Vistica D.T., Hose C.D., Langley J., Cronise P., Vaigro-Wolff A., Gray-Goodrich M., Campbell H., Mayo J.G., Boyd M.R.
Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines.
J. Natl. Cancer Inst. 83:757-766(1991) PubMed=15703300; DOI=10.1073/pnas.0405578102
Roschke A.V., Lababidi S., Tonon G., Gehlhaus K.S., Bussey K.J., Weinstein J.N., Kirsch I.R.
Karyotypic 'state' as a potential determinant for anticancer drug discovery.
Proc. Natl. Acad. Sci. U.S.A. 102:2964-2969(2005) |
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| Cross-references |
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| Cell line collections |
NCI-DTP; KM 20L2
|
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| Anatomy/cell type resources |
BTO; BTO:0005911
|
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| Biological sample resources |
BioSample; SAMN06481115
|
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| Chemistry resources |
ChEMBL-Cells; CHEMBL3307782
ChEMBL-Targets; CHEMBL614791
PubChem_Cell_line; CVCL_D889
|
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| Encyclopedic resources |
Wikidata; Q54900067
|
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| Polymorphism and mutation databases |
IARC_TP53; 28215
|
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| Entry history |
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| Entry creation | 22-Oct-2012 |
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| Last entry update | 21-Mar-2023 |
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| Version number | 27 |
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