Cell line name |
HT29-31 |
Synonyms |
HT29 line 31 |
Accession |
CVCL_E5ZA |
Resource Identification Initiative |
To cite this cell line use: HT29-31 (RRID:CVCL_E5ZA) |
Comments |
Population: Caucasian. Characteristics: Obtained after treatment of parent cell line in polyethylene glycol (PEG). Two types of differentiated cells are present, namely, enterocytic cells and mucus-secreting goblet cells (PubMed=3281752). Doubling time: 25.4 +- 2.5 hours (PubMed=3281752). Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
Sequence variations |
- Mutation; HGNC; HGNC:583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
|
Disease |
Colon adenocarcinoma (NCIt: C4349) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0320 (HT-29) |
Sex of cell |
Female |
Age at sampling |
44Y |
Category |
Cancer cell line |
Publications | PubMed=3281752 Laboisse C.L., Maoret J.-J., Triadou N., Augeron C. Restoration by polyethylene glycol of characteristics of intestinal differentiation in subpopulations of the human colonic adenocarcinoma cell line HT29. Cancer Res. 48:2498-2504(1988) |
Entry history |
Entry creation | 10-Apr-2025 |
Last entry update | 10-Apr-2025 |
Version number | 1 |
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