| Cell line name |
HT29-5FU resistant (10 microMolar) |
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| Synonyms |
HT29-FU |
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| Accession |
CVCL_A8P6 |
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| Resource Identification Initiative |
To cite this cell line use: HT29-5FU resistant (10 microMolar) (RRID:CVCL_A8P6) |
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| Comments |
Population: Caucasian.
Characteristics: Resistant to 10 muM of 5-fluorouracil.
Selected for resistance to: ChEBI; CHEBI:46345; 5-fluorouracil (5-FU).
Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
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| Sequence variations |
- Mutation; HGNC; 583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
|
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| Disease |
Colon adenocarcinoma (NCIt: C4349) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0320 (HT-29)
Children:
|
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| Sex of cell |
Female |
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| Age at sampling |
44Y |
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| Category |
Cancer cell line |
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| STR profile |
Source(s): ECACC
Markers:
Run an STR similarity search on this cell line |
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| Publications | PubMed=1937958; DOI=10.1002/ijc.2910490516
Lesuffleur T., Kornowski A., Luccioni C., Muleris M., Barbat A., Beaumatin J., Dussaulx E., Dutrillaux B., Zweibaum A.
Adaptation to 5-fluorouracil of the heterogeneous human colon tumor cell line HT-29 results in the selection of cells committed to differentiation.
Int. J. Cancer 49:721-730(1991) PubMed=15050369; DOI=10.1016/j.biolcel.2003.12.005
Leteurtre E., Gouyer V., Rousseau K., Moreau O., Barbat A., Swallow D.M., Huet G., Lesuffleur T.
Differential mucin expression in colon carcinoma HT-29 clones with variable resistance to 5-fluorouracil and methotrexate.
Biol. Cell 96:145-151(2004) |
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| Cross-references |
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| Cell line collections (Providers) |
ECACC; 15121709
|
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| Cell line databases/resources |
cancercelllines; CVCL_A8P6
|
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| Encyclopedic resources |
Wikidata; Q102114166
|
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| Entry history |
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| Entry creation | 29-Oct-2020 |
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| Last entry update | 05-Oct-2023 |
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| Version number | 8 |
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