Cell line name |
HT29-5FU resistant (10 microMolar) |
Synonyms |
HT29-5FU resistant (10-5); HT29-FU |
Accession |
CVCL_A8P6 |
Resource Identification Initiative |
To cite this cell line use: HT29-5FU resistant (10 microMolar) (RRID:CVCL_A8P6) |
Comments |
Population: Caucasian. Characteristics: Resistant to 10 muM of 5-fluorouracil (PubMed=1937958). Selected for resistance to: ChEBI; CHEBI_46345; 5-fluorouracil (5-FU). Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
Sequence variations |
- Mutation; HGNC; HGNC:583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
|
Disease |
Colon adenocarcinoma (NCIt: C4349) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0320 (HT-29) Children:
|
Sex of cell |
Female |
Age at sampling |
44Y |
Category |
Cancer cell line |
STR profile |
Source(s): ECACC=15121709
Markers: Run an STR similarity search on this cell line |
Publications | PubMed=1937958; DOI=10.1002/ijc.2910490516 Thecla Lesuffleur, Anne Kornowski, Catherine Luccioni, Martine Muleris, Alain Barbat, Jacqueline Beaumatin, Elisabeth Dussaulx, Bernard Dutrillaux, Alain Zweibaum; Adaptation to 5-fluorouracil of the heterogeneous human colon tumor cell line HT-29 results in the selection of cells committed to differentiation. Int. J. Cancer 49:721-730(1991) PubMed=8308060; DOI=10.1242/jcs.106.3.771 Thecla Lesuffleur, Nicole Porchet, Jean-Pierre Aubert, Dallas M. Swallow, James R. Gum Jr., Young S. Kim, Francisco X. Real, Alain Zweibaum; Differential expression of the human mucin genes MUC1 to MUC5 in relation to growth and differentiation of different mucus-secreting HT-29 cell subpopulations. J. Cell Sci. 106:771-783(1993) PubMed=15050369; DOI=10.1016/j.biolcel.2003.12.005 Emmanuelle Leteurtre, Valerie Gouyer, Karine Rousseau, Odile Moreau, Alain Barbat, Dallas M. Swallow, Guillemette Huet, Thecla Lesuffleur; Differential mucin expression in colon carcinoma HT-29 clones with variable resistance to 5-fluorouracil and methotrexate. Biol. Cell 96:145-151(2004) |
Cross-references |
Cell line collections (Providers) |
ECACC; 15121709
|
Cell line databases/resources |
cancercelllines; CVCL_A8P6
|
Encyclopedic resources |
Wikidata; Q102114166
|
Entry history |
Entry creation | 29-Oct-2020 |
Last entry update | 14-Aug-2025 |
Version number | 11 |
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