| Cell line name |
HT-29/SN-38 |
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| Accession |
CVCL_WV61 |
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| Resource Identification Initiative |
To cite this cell line use: HT-29/SN-38 (RRID:CVCL_WV61) |
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| Comments |
Population: Caucasian.
Doubling time: 30 hours (PubMed=23546019).
Selected for resistance to: ChEBI; CHEBI_8988; SN-38 (7-ethyl-10-hydroxy-camptothecin).
Derived from site: In situ; Colon; UBERON=UBERON_0001155. |
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| Sequence variations |
- Mutation; HGNC; HGNC:583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
|
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| Disease |
Colon adenocarcinoma (NCIt: C4349) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0320 (HT-29) |
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| Sex of cell |
Female |
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| Age at sampling |
44Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=23546019; DOI=10.3892/ijo.2013.1868
Amelie Petitprez, Virginie Poindessous, Djamila Ouaret, Marie Regairaz, Gerard Bastian, Eric Guerin, Alexandre E. Escargueil, Annette K. Larsen;
Acquired irinotecan resistance is accompanied by stable modifications of cell cycle dynamics independent of MSI status.
Int. J. Oncol. 42:1644-1653(2013) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_WV61
|
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| Encyclopedic resources |
Wikidata; Q94304661
|
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| Entry history |
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| Entry creation | 05-Jul-2019 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 11 |
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