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Cellosaurus HT29-19A (CVCL_0323)

[Text version]
Cell line name HT29-19A
Synonyms HT2919A; HT 29/19A; HT29/19A; HT29 cl.19A; HT29-cl19A; HT29 CL19A; HT29 cl 19A; HT 29 cl.19A; HT29-Cl.19A; HT-29 clone 19A; HT29 clone 19A; HT29clone19A
Accession CVCL_0323
Resource Identification Initiative To cite this cell line use: HT29-19A (RRID:CVCL_0323)
Comments Population: Caucasian.
Doubling time: 43.47 hours (PubMed=25944804).
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; 583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0320 (HT-29)
Sex of cell Female
Age at sampling 44Y
Category Cancer cell line

Augeron C., Laboisse C.L.
Emergence of permanently differentiated cell clones in a human colonic cancer cell line in culture after treatment with sodium butyrate.
Cancer Res. 44:3961-3969(1984)

PubMed=12508250; DOI=10.1002/gcc.10163
Kuechler A., Weise A., Michel S., Schaeferhenrich A., Pool-Zobel B.L., Claussen U., Liehr T.
Precise breakpoint characterization of the colon adenocarcinoma cell line HT-29 clone 19A by means of 24-color fluorescence in situ hybridization and multicolor banding.
Genes Chromosomes Cancer 36:207-210(2003)

PubMed=12714179; DOI=10.1016/S0027-5107(03)00012-5
Schaeferhenrich A., Beyer-Sehlmeyer G., Festag G., Kuechler A., Haag N., Weise A., Liehr T., Claussen U., Marian B., Sendt W., Scheele J., Pool-Zobel B.L.
Human adenoma cells are highly susceptible to the genotoxic action of 4-hydroxy-2-nonenal.
Mutat. Res. 526:19-32(2003)

PubMed=15463957; DOI=10.1016/j.jcf.2004.05.040
Gruenert D.C., Willems M., Cassiman J.-J., Frizzell R.A.
Established cell lines used in cystic fibrosis research.
J. Cyst. Fibros. 3:191-196(2004)

PubMed=25944804; DOI=10.1158/1078-0432.CCR-14-2457
Bazzocco S., Dopeso H., Carton-Garcia F., Macaya I., Andretta E., Chionh F., Rodrigues P., Garrido M., Alazzouzi H., Nieto R., Sanchez A., Schwartz S. Jr., Bilic J., Mariadason J.M., Arango D.
Highly expressed genes in rapidly proliferating tumor cells as new targets for colorectal cancer treatment.
Clin. Cancer Res. 21:3695-3704(2015)

Cell line databases/resources MCCL; MCC:0000216
cancercelllines; CVCL_0323
Encyclopedic resources Wikidata; Q54896591
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number24