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Cellosaurus HT29-19A (CVCL_0323)

[Text version]
Cell line name HT29-19A
Synonyms HT2919A; HT 29/19A; HT29/19A; HT29 cl.19A; HT29-cl19A; HT29 CL19A; HT29 cl 19A; HT 29 cl.19A; HT29-Cl.19A; HT-29 clone 19A; HT29 clone 19A; HT29clone19A
Accession CVCL_0323
Resource Identification Initiative To cite this cell line use: HT29-19A (RRID:CVCL_0323)
Comments Population: Caucasian.
Doubling time: 43.47 hours (PubMed=25944804).
Misspelling: HT29-C1.19A; ABM=T8212; Note=In old versions, corrected in Jan 2025.
Derived from site: In situ; Colon; UBERON=UBERON_0001155.
Sequence variations
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0320 (HT-29)
Sex of cell Female
Age at sampling 44Y
Category Cancer cell line
Publications

PubMed=6744312
Chantal Augeron, Christian L. Laboisse;
Emergence of permanently differentiated cell clones in a human colonic cancer cell line in culture after treatment with sodium butyrate.
Cancer Res. 44:3961-3969(1984)

PubMed=12508250; DOI=10.1002/gcc.10163
Alma Kuechler, Anja Weise, Susanne Michel, Anja Schaeferhenrich, Beatrice Louise Pool-Zobel, Uwe Claussen, Thomas Liehr;
Precise breakpoint characterization of the colon adenocarcinoma cell line HT-29 clone 19A by means of 24-color fluorescence in situ hybridization and multicolor banding.
Genes Chromosomes Cancer 36:207-210(2003)

PubMed=12714179; DOI=10.1016/S0027-5107(03)00012-5
Anja Schaeferhenrich, Gabriele Beyer-Sehlmeyer, Grit Festag, Alma Kuechler, Natja Haag, Anja Weise, Thomas Liehr, Uwe Claussen, Brigitte Marian, Wolfgang Sendt, Johannes Scheele, Beatrice Louise Pool-Zobel;
Human adenoma cells are highly susceptible to the genotoxic action of 4-hydroxy-2-nonenal.
Mutat. Res. 526:19-32(2003)

PubMed=15463957; DOI=10.1016/j.jcf.2004.05.040
Dieter C. Gruenert, Marjolaine Willems, Jean-Jacques Cassiman, Raymond A. Frizzell;
Established cell lines used in cystic fibrosis research.
J. Cyst. Fibros. 3:191-196(2004)

PubMed=25944804; DOI=10.1158/1078-0432.CCR-14-2457
Sarah Bazzocco, Higinio Dopeso, Fernando Carton-Garcia, Irati Macaya, Elena Andretta, Fiona Chionh, Paulo Rodrigues, Miriam Garrido, Hafid Alazzouzi, Rocio Nieto, Alex Sanchez ...Show all 15 authors... , Simo Schwartz Jr., Josipa Bilic, John M. Mariadason, Diego Arango; Show fewer authors
Highly expressed genes in rapidly proliferating tumor cells as new targets for colorectal cancer treatment.
Clin. Cancer Res. 21:3695-3704(2015)

Cross-references
Cell line collections (Providers) ABM; T8212
Cell line databases/resources MCCL; MCC:0000216
cancercelllines; CVCL_0323
Encyclopedic resources Wikidata; Q54896591
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number26