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Cellosaurus A2780 (CVCL_0134)

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Cell line name A2780
Synonyms A-2780; 2780; A2780S; A2780par
Accession CVCL_0134
Resource Identification Initiative To cite this cell line use: A2780 (RRID:CVCL_0134)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: KuDOS 95 cell line panel.
Part of: MD Anderson Cell Lines Project.
Part of: OCCP ovarian cancer cell line panel.
Population: African American.
Doubling time: 25.3 +- 1 hours (PubMed=3539322); 16 hours (PubMed=25984343); 18.41 hours (JWGray panel).
Microsatellite instability: Instable (MSI-low) (PubMed=15677628; Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Genomics; Whole genome sequencing.
Omics: Glycomics; N-glycan profiling; Lectin array.
Omics: Metabolomics.
Omics: Phenotyping; CRISPR screening.
Omics: Phenotyping; Drug screening.
Omics: Proteomics.
Omics: Proteomics; 2DE-MS.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; PTM; GPI-anchored proteins.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Transcriptomics; Serial analysis of gene expression (SAGE).
Omics: Variations; Array-based CGH.
Omics: Variations; SNP array analysis.
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Sequence variations
  • Mutation; HGNC; HGNC:795; ATM; Simple; p.Pro604Ser (c.1810C>T); ClinVar=VCV000127343; Zygosity=Unspecified (PubMed=25846456).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu365Lys (c.1093G>A); ClinVar=VCV000419222; Zygosity=Heterozygous (DepMap=ACH-000657).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys128_Arg130del (c.383_391del9); Zygosity=Homozygous (PubMed=25230021; DepMap=ACH-000657).
  • Mutation; HGNC; HGNC:17271; RRAS2; Simple; p.Gln72Leu (c.215A>T); ClinVar=VCV000009447; Zygosity=Homozygous (DepMap=ACH-000657).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*26:03,26:03
HLA-BB*37:04,49:01
HLA-CC*02:02,07:01
Class II
HLA-DQDQB1*06:07,06:07
HLA-DRDRB1*01:01,01:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African93.08
Native American0
East Asian, North2.76
East Asian, South0
South Asian0
European, North0
European, South4.17
Disease Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Endometrioid carcinoma of ovary (ORDO: Orphanet_454723)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_C9BP (2780AD)CVCL_C3NF (A2780 LIN28B KO)CVCL_C0D6 (A2780 PTX(4))
CVCL_E5L2 (A2780 RRAS2 KO#20)CVCL_E5L1 (A2780 RRAS2 KO#3)CVCL_H619 (A2780-1A9)
CVCL_ZE22 (A2780-CBDCA-R)CVCL_H745 (A2780-cisR)CVCL_EG64 (A2780-DR)
CVCL_4T95 (A2780-DX1)CVCL_TZ68 (A2780-M)CVCL_E5I4 (A2780-NiraR)
CVCL_DI16 (A2780-SCA)CVCL_1F93 (A2780-TC1)CVCL_7224 (A2780/100)
CVCL_D156 (A2780/ACR6)CVCL_D157 (A2780/ACRP)CVCL_B037 (A2780/AD10)
CVCL_D537 (A2780/ADDP)CVCL_B7S7 (A2780/C100)CVCL_F638 (A2780/C200)
CVCL_F639 (A2780/C30)CVCL_B7S6 (A2780/C300)CVCL_B7S8 (A2780/C50)
CVCL_B7S5 (A2780/C80)CVCL_D620 (A2780/CBP)CVCL_Y180 (A2780/cDDP)
CVCL_D619 (A2780/CDDP)CVCL_A5AB (A2780/cmv)CVCL_A5PS (A2780/CP20)
CVCL_0135 (A2780/CP70)CVCL_A5PT (A2780/CP8)CVCL_A5AC (A2780/m175)
CVCL_A5AD (A2780/m248)CVCL_A5AE (A2780/m273)CVCL_4862 (A2780/R)
CVCL_4863 (A2780/S)CVCL_IJ13 (A2780/Taxol)CVCL_4V45 (A2780/TPT)
CVCL_UJ39 (A2780AD)CVCL_1941 (A2780ADR)CVCL_1942 (A2780cis)
CVCL_UJ38 (A2780ME)CVCL_C1NE (A2780veliR)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): AddexBio=C0017002/20; Cosmic-CLP=906804; ECACC=93112519; ICLC=HTL98008; PubMed=11416159; PubMed=25230021; PubMed=25877200; PubMed=30485824

Markers:
AmelogeninX
CSF1PO10,11
D2S133821,22
D3S135814,16
D5S81811,12
D7S82010
D8S117915,17
D13S31712,13
D16S53911,12,13 (ICLC=HTL98008)
11,13 (AddexBio=C0017002/20; Cosmic-CLP=906804; ECACC=93112519; PubMed=25230021; PubMed=25877200; PubMed=30485824)
D18S5116,18
D19S43312
D21S1128 (PubMed=25230021; PubMed=25877200)
28,29 (PubMed=30485824)
FGA19,24
Penta D8,9
Penta E10,13
TH016
TPOX8,10
vWA15,16

Run an STR similarity search on this cell line
Web pages Info; ECACC; -; https://www.culturecollections.org.uk/products/cell-cultures/ecacc-cell-line-profiles/a2780/
Info; MCLP; -; https://tcpaportal.org/mclp/
Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/2/cell-lines-detail-64.html
Publications

PubMed=6954533; DOI=10.1073/pnas.79.7.2194; PMCID=PMC346157
Eric H. Westin, Robert Charles Gallo, Suresh K. Arya, Alessandra Eva, Lawrence M. Souza, Marcel Albert Baluda, Stuart A. Aaronson, Flossie Wong-Staal;
Differential expression of the amv gene in human hematopoietic cells.
Proc. Natl. Acad. Sci. U.S.A. 79:2194-2198(1982)

PubMed=6372095; DOI=10.1126/science.6372095
Alfred M. Rogan, Thomas C. Hamilton, Robert C. Young, Raymond W. Klecker Jr., Robert F. Ozols;
Reversal of adriamycin resistance by verapamil in human ovarian cancer.
Science 224:994-996(1984)

PubMed=3986765
Karen Guigere Louie, Brent C. Behrens, Timothy James Kinsella, Thomas C. Hamilton, Karen R. Grotzinger, Wilma M. McKoy, Margaret A. Winker, Robert F. Ozols;
Radiation survival parameters of antineoplastic drug-sensitive and -resistant human ovarian cancer cell lines and their modification by buthionine sulfoximine.
Cancer Res. 45:2110-2115(1985)

PubMed=2429947; DOI=10.20772/cancersci1985.77.9_941
Takashi Tsuruo, Thomas C. Hamilton, Karen Guigere Louie, Brent C. Behrens, Robert C. Young, Robert F. Ozols;
Collateral susceptibility of adriamycin-, melphalan- and cisplatin-resistant human ovarian tumor cells to bleomycin.
Jpn. J. Cancer Res. 77:941-945(1986)

PubMed=3539322
Brent C. Behrens, Thomas C. Hamilton, Hidetaka Masuda, Karen R. Grotzinger, Jacqueline Whang-Peng, Karen Guigere Louie, Turid Knutsen, Wilma M. McKoy, Robert C. Young, Robert F. Ozols;
Characterization of a cis-diamminedichloroplatinum(II)-resistant human ovarian cancer cell line and its use in evaluation of platinum analogues.
Cancer Res. 47:414-418(1987)

PubMed=3335022
Michael C. Alley, Dominic A. Scudiero, Anne Monks, Miriam L. Hursey, Maciej J. Czerwinski, Donald L. Fine, Betty Jane Abbott, Joseph G. Mayo, Robert H. Shoemaker, Michael R. Boyd;
Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.
Cancer Res. 48:589-601(1988)

PubMed=2751261
Alessandra Mazzoni, Fabio Trave, Gianfranco Canti, Paola Franco;
Effect of the tiapamil analog RO11-2933 on cellular sensitivity to antitumor drugs in sensitive and multidrug resistant human ovarian cancer cells.
Anticancer Res. 9:367-371(1989)

PubMed=1999494; DOI=10.1172/JCI115080; PMCID=PMC329864
Ricardo J. Parker, Alan Eastman, Frieda Bostick-Bruton, Eddie Reed;
Acquired cisplatin resistance in human ovarian cancer cells is associated with enhanced repair of cisplatin-DNA lesions and reduced drug accumulation.
J. Clin. Invest. 87:772-777(1991)

PubMed=1348364; DOI=10.1073/pnas.89.7.3070; PMCID=PMC48805
Andrew Kent Godwin, Alton Meister, Peter J. O'Dwyer, Chin-Shiou Huang, Thomas C. Hamilton, Mary E. Anderson;
High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis.
Proc. Natl. Acad. Sci. U.S.A. 89:3070-3074(1992)

PubMed=8012063
Guido Cimoli, Monica Valenti, Silvio Parodi, Alessandra Mazzoni, Fabio De Sessa, PierFranco Conte, Patrizia Russo;
Reversal of 'atypical'-multidrug resistance by recombinant human tumor necrosis factor in the human ovarian cancer cell line A2780-DX3.
Oncol. Res. 5:311-323(1993)

PubMed=7927910; DOI=10.1002/ijc.2910590118
Ian M. Huxham, Andrew L. Barlow, Alexander D. Lewis, Jane Plumb, Robert J. Mairs, Mark N. Gaze, Paul Workman;
Differential intracellular processing of the anthracycline drug ME2303 in doxorubicin-sensitive (A2780) and -resistant (A2780AD) human ovarian cancer cells as studied with confocal laser scanning microscopy and image analysis.
Int. J. Cancer 59:94-102(1994)

PubMed=8557231; DOI=10.1006/gyno.1996.0014
Jeffrey S. Skilling, Robert C. Squatrito, Joseph P. Connor, Theodore Niemann, Richard E. Buller;
p53 gene mutation analysis and antisense-mediated growth inhibition of human ovarian carcinoma cell lines.
Gynecol. Oncol. 60:72-80(1996)

PubMed=9041185
Steven W. Johnson, Paul B. Laub, Jacqueline S. Beesley, Robert F. Ozols, Thomas C. Hamilton;
Increased platinum-DNA damage tolerance is associated with cisplatin resistance and cross-resistance to various chemotherapeutic agents in unrelated human ovarian cancer cell lines.
Cancer Res. 57:850-856(1997)

PubMed=11103784
Colleen D. Hough, Cheryl A. Sherman-Baust, Ellen S. Pizer, Fredrick John Montz, Dwight D. Im, Neil B. Rosenshein, Kathleen R. Cho, Gregory J. Riggins, Patrice J. Morin;
Large-scale serial analysis of gene expression reveals genes differentially expressed in ovarian cancer.
Cancer Res. 60:6281-6287(2000)

PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459
John R.W. Masters, Jim A. Thomson, Bernadette Daly-Burns, Yvonne A. Reid, Wilhelm Gerhard Dirks, Phil Packer, Lorraine H. Toji, Tadao Ohno, Hideyuki Tanabe, Colin Francis Arlett, Lloyd R. Kelland ...Show all 16 authors... , Maureen Harrison, Arvind K. Virmani, Timothy H. Ward, Karen L. Ayres, Paul G. Debenham; Show fewer authors
Short tandem repeat profiling provides an international reference standard for human cell lines.
Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001)

PubMed=12080474; DOI=10.1038/sj.onc.1205542
Ramon G. Manzano, Luis M. Montuenga, Mark A. Dayton, Paul Dent, Ichiro Kinoshita, Silvestre Vicent, Ginger J. Gardner, PhuongMai Nguyen, Yung-Hyun Choi, Jane B. Trepel, Nelly Auersperg, Michael J. Birrer;
CL100 expression is down-regulated in advanced epithelial ovarian cancer and its re-expression decreases its malignant potential.
Oncogene 21:4435-4447(2002)

PubMed=15677628; DOI=10.1093/carcin/bgi032
Kylie Louise Gorringe, Suet-Feung Chin, Paul D.P. Pharoah, Joanne M. Staines, Carla Oliveira, Paul A.W. Edwards, Carlos Caldas;
Evidence that both genetic instability and selection contribute to the accumulation of chromosome alterations in cancer.
Carcinogenesis 26:923-930(2005)

PubMed=18273836; DOI=10.1002/gcc.20547
Mona Prasad, Marcus Bernardini, Anya Tsalenko, Paula Marrano, Jana Paderova, Chung-Hae Lee, Amir Ben-Dor, Michael T. Barrett, Jeremy Andrew Squire;
High definition cytogenetics and oligonucleotide aCGH analyses of cisplatin-resistant ovarian cancer cells.
Genes Chromosomes Cancer 47:427-436(2008)

PubMed=19714814; DOI=10.1021/pr800856b
Lucia Cicchillitti, Michela Di Michele, Andrea Urbani, Cristiano Ferlini, Maria Benedetta Donati, Giovanni Scambia, Domenico Rotilio;
Comparative proteomic analysis of paclitaxel sensitive A2780 epithelial ovarian cancer cell line and its resistant counterpart A2780TC1 by 2D-DIGE: the role of ERp57.
J. Proteome Res. 8:1902-1912(2009)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20204287; DOI=10.3892/or_00000728; PMCID=PMC2909445
Gregory T. Langland, Steven M. Yannone, Rachel A. Langland, Aki Nakao, Ying-Hui Guan, Sydney B.T. Long, Lien Vonguyen, David J. Chen, Joe W. Gray, Fan-Qing Chen;
Radiosensitivity profiles from a panel of ovarian cancer cell lines exhibiting genetic alterations in p53 and disparate DNA-dependent protein kinase activities.
Oncol. Rep. 23:1021-1026(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22328975; DOI=10.1158/2159-8290.CD-11-0170; PMCID=PMC3274821
Aphrothiti J. Hanrahan, Nikolaus Schultz, Maggie L. Westfal, Rita A. Sakr, Dilip D. Giri, Stefano Scarperi, Manickam Janakiraman, Narciso Olvera, Ellen V. Stevens, Qing-Bai She, Carol Aghajanian ...Show all 20 authors... , Tari A. King, Elisa de Stanchina, David R. Spriggs, Adriana Heguy, Barry Stephen Taylor, Chris Sander, Neal Rosen, Douglas A. Levine, David B. Solit; Show fewer authors
Genomic complexity and AKT dependence in serous ovarian cancer.
Cancer Discov. 2:56-67(2012)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22585861; DOI=10.1158/2159-8290.CD-11-0224; PMCID=PMC5057396
Richard Marcotte, Kevin R. Brown, Fernando Jose Suarez Saiz, Azin Sayad, Konstantina Karamboulas, Paul M. Krzyzanowski, Fabrice Sircoulomb, Mauricio Medrano, Yaroslav Fedyshyn, Judice Lie-Yong Koh, Dewald van Dyk ...Show all 28 authors... , Bohdana Fedyshyn, Marianna Luhova, Glauber C. Brito, Franco J. Vizeacoumar, Frederick S. Vizeacoumar, Alessandro Datti, Dahlia Kasimer, Alla Buzina, Patricia Mero, Christine Misquitta, Josee Normand, Maliha Haider, Troy Ketela, Jeffrey L. Wrana, Robert Rottapel, Benjamin G. Neel, Jason Moffat; Show fewer authors
Essential gene profiles in breast, pancreatic, and ovarian cancer cells.
Cancer Discov. 2:172-189(2012)

PubMed=22705003; DOI=10.1016/j.humpath.2012.03.011
Munmun Rahman, Kentaro Nakayama, Mohammed Tanjimur Rahman, Naomi Nakayama, Masako Ishikawa, Atsuko Katagiri, Kouji Iida, Satoru Nakayama, Yoshiro Otsuki, Ie-Ming Shih, Kohji Miyazaki;
Clinicopathologic and biological analysis of PIK3CA mutation in ovarian clear cell carcinoma.
Hum. Pathol. 43:2197-2206(2012)

PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017; PMCID=PMC3432677
Christopher T. Korch, Monique A. Spillman, Twila A. Jackson, Britta M. Jacobsen, Susan K. Murphy, Bruce Arthur Lessey, Virgil Craig Jordan, Andrew Peter Bradford;
DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.
Gynecol. Oncol. 127:241-248(2012)

PubMed=23415752; DOI=10.1016/j.molonc.2012.12.007; PMCID=PMC4106023
Britta Stordal, Kirsten Timms, Angela Farrelly, Danielle Gallagher, Steven Busschots, Mickael Renaud, Julien Thery, Deborah Williams, Jennifer Potter, Thanh Tran, Greg Korpanty ...Show all 19 authors... , Mattia Cremona, Mark S. Carey, Jie Li, Yang Li, Ozlem Aslan, John J. O'Leary, Gordon B. Mills, Bryan T. Hennessy; Show fewer authors
BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one functionally deleterious BRCA1 mutation.
Mol. Oncol. 7:567-579(2013)

PubMed=23839242; DOI=10.1038/ncomms3126; PMCID=PMC3715866
Silvia Domcke, Rileen Sinha, Douglas A. Levine, Chris Sander, Nikolaus Schultz;
Evaluating cell lines as tumour models by comparison of genomic profiles.
Nat. Commun. 4:2126.1-2126.10(2013)

PubMed=24023729; DOI=10.1371/journal.pone.0072162; PMCID=PMC3762837
Michael S. Anglesio, Kimberly C. Wiegand, Nataliya Melnyk, Christine Chow, Clara M. Salamanca, Leah M. Prentice, Janine Senz, Winnie Yang, Monique A. Spillman, Dawn R. Cochrane, Karey Shumansky ...Show all 14 authors... , Sohrab P. Shah, Steve E. Kalloger, David G. Huntsman; Show fewer authors
Type-specific cell line models for type-specific ovarian cancer research.
PLoS ONE 8:e72162.1-e72162.13(2013)

PubMed=25230021; DOI=10.1371/journal.pone.0103988; PMCID=PMC4167545
Corine M. Beaufort, Jean C.A. Helmijr, Anna M. Piskorz, Marlous Hoogstraat, Kirsten Ruigrok-Ritstier, Nicolle Besselink, Muhammed Murtaza, Wilfred F.J. van IJcken, Anouk A.J. Heine, Marcel Smid, Marco J. Koudijs ...Show all 14 authors... , James D. Brenton, Els M.J.J. Berns, Jozien Helleman; Show fewer authors
Ovarian cancer cell line panel (OCCP): clinical importance of in vitro morphological subtypes.
PLoS ONE 9:e103988.1-e103988.16(2014)

PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652
Glenn S. Cowley, Barbara A. Weir, Francisca Vazquez, Pablo Tamayo, Justine A. Scott, Scott Rusin, Alexandra East-Seletsky, Levi D. Ali, William F.J. Gerath, Sarah E. Pantel, Patrick Hall Lizotte ...Show all 40 authors... , Guo-Zhi Jiang, Jessica Hsiao, Aviad Tsherniak, Elizabeth Dwinell, Simon Aoyama, Michael Okamoto, William Harrington, Ellen T. Gelfand, Thomas M. Green, Mark J. Tomko, Shuba Gopal, Terence C. Wong, Hu-Bo Li, Sara Howell, Nicolas Stransky, Ted Liefeld, Dongkeun Jang, Jonathan Bistline, Barbara Hill Meyers, Scott Allen Armstrong, Kenneth Carl Anderson, Kimberly Stegmaier, Michael Reich, David Pellman, Jesse S. Boehm, Jill P. Mesirov, Todd Robert Golub, David E. Root, William Chun Hahn; Show fewer authors
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035.1-140035.12(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25846456; DOI=10.3892/ijo.2015.2951
Masataka Takenaka, Motonobu Saito, Reika Iwakawa, Nozomu Yanaihara, Misato Saito, Mamoru Kato, Hitoshi Ichikawa, Tatsuhiro Shibata, Jun Yokota, Aikou Okamoto, Takashi Kohno;
Profiling of actionable gene alterations in ovarian cancer by targeted deep sequencing.
Int. J. Oncol. 46:2389-2398(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=26972028; DOI=10.1016/j.jprot.2016.03.008
Yusuke Masuishi, Yayoi Kimura, Noriaki Arakawa, Hisashi Hirano;
Identification of glycosylphosphatidylinositol-anchored proteins and omega-sites using TiO2-based affinity purification followed by hydrogen fluoride treatment.
J. Proteomics 139:77-83(2016)

PubMed=27141528; DOI=10.1016/j.dib.2016.04.001; PMCID=PMC4838930
Yusuke Masuishi, Yayoi Kimura, Noriaki Arakawa, Hisashi Hirano;
Data for identification of GPI-anchored peptides and omega-sites in cancer cell lines.
Data Brief 7:1302-1305(2016)

PubMed=27235858; DOI=10.1016/j.ygyno.2016.05.028; PMCID=PMC4961516
Lidia Hernandez, Marianne K. Kim, L. Tiffany Lyle, Kristen P. Bunch, Carrie D. House, Franklin Ning, Anne M. Noonan, Christina Messineo Annunziata;
Characterization of ovarian cancer cell lines as in vivo models for preclinical studies.
Gynecol. Oncol. 142:332-340(2016)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=27561551; DOI=10.1038/ncomms12645; PMCID=PMC5007461
Fabian Coscia, Karen M. Watters, Marion Curtis, Mark A. Eckert, Chun-Yi Chiang, Stefka Tyanova, Anthony Montag, Ricardo R. Lastra, Ernst Robert Lengyel, Matthias Mann;
Integrative proteomic profiling of ovarian cancer cell lines reveals precursor cell associated proteins and functional status.
Nat. Commun. 7:12645.1-12645.14(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=28273451; DOI=10.1016/j.celrep.2017.02.028
Mauricio Medrano, Laudine Communal, Kevin R. Brown, Marcin Iwanicki, Josee Normand, Joshua Paterson, Fabrice Sircoulomb, Paul M. Krzyzanowski, Marian Novak, Sasha A. Doodnauth, Fernando Jose Suarez Saiz ...Show all 19 authors... , Jane Cullis, Rima Al-awar, Benjamin G. Neel, John McPherson, Ronny I. Drapkin, Laurie Ailles, Anne-Marie Mes-Masson, Robert Rottapel; Show fewer authors
Interrogation of functional cell-surface markers identifies CD151 dependency in high-grade serous ovarian cancer.
Cell Rep. 18:2343-2358(2017)

PubMed=28546799; DOI=10.1186/s12014-017-9155-z; PMCID=PMC5442857
Ran Zhao, Wen-Jun Qin, Rui-Huan Qin, Jing Han, Can Li, Yi-Sheng Wang, Cong-Jian Xu;
Lectin array and glycogene expression analyses of ovarian cancer cell line A2780 and its cisplatin-resistant derivate cell line A2780-cp.
Clin. Proteomics 14:20.1-20.10(2017)

PubMed=30485824; DOI=10.1016/j.celrep.2018.10.096; PMCID=PMC6481945
Eniko Papp, Dorothy Hallberg, Gottfried E. Konecny, Daniel C. Bruhm, Vilmos Adleff, Michael Noe, Ioannis Kagiampakis, Doreen Palsgrove, Dylan Conklin, Yasuto Kinose, James R. White ...Show all 18 authors... , Michael F. Press, Ronny I. Drapkin, Hariharan Easwaran, Stephen Bruce Baylin, Dennis Joseph Slamon, Victor E. Velculescu, Robert B. Scharpf; Show fewer authors
Integrated genomic, epigenomic, and expression analyses of ovarian cancer cell lines.
Cell Rep. 25:2617-2633(2018)

PubMed=30894224; DOI=10.1186/s40659-019-0220-0; PMCID=PMC6427839
Tamara Viscarra, Kurt Buchegger, Ignacio Andres Jofre, Ismael Riquelme, Louise Zanella, Michel Abanto Marin, Alyssa C. Parker, Stephen R. Piccolo, Juan Carlos Roa, Carmen Gloria Ili, Priscilla Brebi;
Functional and transcriptomic characterization of carboplatin-resistant A2780 ovarian cancer cell line.
Biol. Res. 52:13.1-13.13(2019)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=30971826; DOI=10.1038/s41586-019-1103-9
Fiona M. Behan, Francesco Iorio, Gabriele Picco, Emanuel Goncalves, Charlotte M. Beaver, Giorgia Migliardi, Rita Santos, Yanhua Rao, Francesco Sassi, Marika Pinnelli, Rizwan Ansari ...Show all 25 authors... , Sarah Harper, David Adam Jackson, Rebecca McRae, Rachel Pooley, Piers Wilkinson, Dieudonne J. van der Meer, David Dow, Carolyn A. Buser-Doepner, Andrea Bertotti, Livio Trusolino, Euan Alexander Stronach, Julio Saez-Rodriguez, Kosuke Yusa, Mathew J. Garnett; Show fewer authors
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Nature 568:511-516(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254
David Paul Nusinow, John Szpyt, Mahmoud Ghandi, Christopher M. Rose, E. Robert McDonald 3rd, Marian Kalocsay, Judit Jane-Valbuena, Ellen T. Gelfand, Devin K. Schweppe, Mark P. Jedrychowski, Javad Golji ...Show all 20 authors... , Dale A. Porter, Tomas Rejtar, Y. Karen Wang, Gregory V. Kryukov, Frank Stegmeier, Brian K. Erickson, Levi Alexander Garraway, William Raj Sellers, Steven P. Gygi; Show fewer authors
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

PubMed=33287223; DOI=10.3390/ijms21239218; PMCID=PMC7730278
Jolanta Szenajch, Alicja Szabelska-Beresewicz, Aleksandra Swiercz, Joanna Zyprych-Walczak, Idzi Siatkowski, Michal Goralski, Agnieszka Synowiec, Luiza Handschuh;
Transcriptome remodeling in gradual development of inverse resistance between paclitaxel and cisplatin in ovarian cancer cells.
Int. J. Mol. Sci. 21:9218.1-9218.30(2020)

PubMed=34071702; DOI=10.3390/ijms22115814; PMCID=PMC8198185
Hadar Golan Berman, Pooja Chauhan, Shira Shalev, Hiba Hassanain, Avital Parnas, Sheera Adar;
Genomic characterization of cisplatin response uncovers priming of cisplatin-induced genes in a resistant cell line.
Int. J. Mol. Sci. 22:5814.1-5814.14(2021)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

PubMed=36476833; DOI=10.1038/s41388-022-02563-9; PMCID=PMC9883167
Laura Clavain, Maria Isabel Fernandez-Pisonero, Nieves Movilla, Luis Francisco Lorenzo-Martin, Blanca Nieto, Antonio Abad, Rosula Garcia-Navas, Clara Llorente-Gonzalez, Manuel Sanchez-Martin, Miguel Vicente-Manzanares, Eugenio Santos ...Show all 15 authors... , Balbino Alarcon, Jose Manuel Garcia-Aznar, Mercedes Dosil, Xose R. Bustelo; Show fewer authors
Characterization of mutant versions of the R-RAS2/TC21 GTPase found in tumors.
Oncogene 42:389-405(2023)

Cross-references
Cell line collections (Providers) ABM; T8089
AddexBio; C0017002/20
BCRJ; 0031
CancerTools; 152706
CLS; 300491
ECACC; 93112519 - Discontinued
ICLC; HTL98008
NCI-DTP; A2780
Ximbio; 152706
Cell line databases/resources CLO; CLO_0001571
MCCL; MCC:0000027
CLDB; cl193
CLDB; cl194
CLDB; cl4894
cancercelllines; CVCL_0134
Cell_Model_Passport; SIDM00210
Cosmic-CLP; 906804
DepMap; ACH-000657
LINCS_LDP; LCL-1518
Lonza; 207
Anatomy/cell type resources BTO; BTO_0002549
Biological sample resources BioSample; SAMN03472806
BioSample; SAMN10988216
CRISP screens repositories BioGRID_ORCS_Cell_line; 329
Chemistry resources ChEMBL-Cells; CHEMBL3308421
ChEMBL-Targets; CHEMBL614004
GDSC; 906804
PharmacoDB; A2780_40_2019
PubChem_Cell_line; CVCL_0134
Encyclopedic resources Wikidata; Q54606559
Experimental variables resources EFO; EFO_0006362
Gene expression databases ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM184388
GEO; GSM184389
GEO; GSM383925
GEO; GSM503257
GEO; GSM659370
GEO; GSM711722
GEO; GSM827312
GEO; GSM851909
GEO; GSM886853
GEO; GSM887918
GEO; GSM1001419
GEO; GSM1001420
GEO; GSM1001488
GEO; GSM1291126
GEO; GSM1291129
GEO; GSM1340577
GEO; GSM1374380
GEO; GSM1374381
GEO; GSM1669581
GEO; GSM2474971
GEO; GSM4845007
GEO; GSM4845008
GEO; GSM6065211
GEO; GSM6065212
GEO; GSM6065213
Metabolomic databases MetaboLights; MTBLS156
MetaboLights; MTBLS1014
Polymorphism and mutation databases Cosmic; 688090
Cosmic; 755844
Cosmic; 849607
Cosmic; 906804
Cosmic; 923108
Cosmic; 948284
Cosmic; 987394
Cosmic; 1093558
Cosmic; 1102819
Cosmic; 1139223
Cosmic; 1198265
Cosmic; 1305309
Cosmic; 1609529
Cosmic; 1707564
Cosmic; 1708387
Cosmic; 1709251
Cosmic; 1945872
Cosmic; 1995331
Cosmic; 2582805
Cosmic; 2674698
IARC_TP53; 21161
LiGeA; CCLE_809
Progenetix; CVCL_0134
Proteomic databases PRIDE; PXD001176
PRIDE; PXD003105
PRIDE; PXD003252
PRIDE; PXD003668
PRIDE; PXD013811
PRIDE; PXD030304
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number49