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Cellosaurus A2780/CP70 (CVCL_0135)

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Cell line name A2780/CP70
Synonyms A2780/cp70; A2780 CP70; A2780(CP70); A2780CP70; A2780/CP; A2780-CP; A2780-cp; A 2780 CP; A2780CP; 2780CP; CP70; CP-70
Accession CVCL_0135
Resource Identification Initiative To cite this cell line use: A2780/CP70 (RRID:CVCL_0135)
Comments Part of: MD Anderson Cell Lines Project.
Population: African American.
Selected for resistance to: ChEBI; CHEBI_27899; Cisplatin (CDDP).
Omics: Glycomics; N-glycan profiling; Lectin array.
Omics: Proteomics.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Transcriptomics; Microarray.
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Sequence variations
  • Mutation; HGNC; HGNC:795; ATM; Simple; p.Pro604Ser (c.1810C>T); ClinVar=VCV000127343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu365Lys (c.1093G>A); ClinVar=VCV000419222; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys128_Arg130del (c.383_391del9); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:17271; RRAS2; Simple; p.Gln72Leu (c.215A>T); ClinVar=VCV000009447; Zygosity=Homozygous (from parent cell line).
Disease Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Endometrioid carcinoma of ovary (ORDO: Orphanet_454723)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0134 (A2780)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): PubMed=17254797

Markers:
AmelogeninX
CSF1PO11
D3S135814,16
D5S81811,12
D7S8209,10
D8S117915,17
D13S31713
D16S53911,13
D18S5116,18
D21S1127,28
FGA19,24
TH016
TPOX8,10
vWA15,16

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Publications

PubMed=2429947; DOI=10.20772/cancersci1985.77.9_941
Takashi Tsuruo, Thomas C. Hamilton, Karen Guigere Louie, Brent C. Behrens, Robert C. Young, Robert F. Ozols;
Collateral susceptibility of adriamycin-, melphalan- and cisplatin-resistant human ovarian tumor cells to bleomycin.
Jpn. J. Cancer Res. 77:941-945(1986)

PubMed=3539322
Brent C. Behrens, Thomas C. Hamilton, Hidetaka Masuda, Karen R. Grotzinger, Jacqueline Whang-Peng, Karen Guigere Louie, Turid Knutsen, Wilma M. McKoy, Robert C. Young, Robert F. Ozols;
Characterization of a cis-diamminedichloroplatinum(II)-resistant human ovarian cancer cell line and its use in evaluation of platinum analogues.
Cancer Res. 47:414-418(1987)

PubMed=3335022
Michael C. Alley, Dominic A. Scudiero, Anne Monks, Miriam L. Hursey, Maciej J. Czerwinski, Donald L. Fine, Betty Jane Abbott, Joseph G. Mayo, Robert H. Shoemaker, Michael R. Boyd;
Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.
Cancer Res. 48:589-601(1988)

PubMed=1999494; DOI=10.1172/JCI115080; PMCID=PMC329864
Ricardo J. Parker, Alan Eastman, Frieda Bostick-Bruton, Eddie Reed;
Acquired cisplatin resistance in human ovarian cancer cells is associated with enhanced repair of cisplatin-DNA lesions and reduced drug accumulation.
J. Clin. Invest. 87:772-777(1991)

PubMed=1348364; DOI=10.1073/pnas.89.7.3070; PMCID=PMC48805
Andrew Kent Godwin, Alton Meister, Peter J. O'Dwyer, Chin-Shiou Huang, Thomas C. Hamilton, Mary E. Anderson;
High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis.
Proc. Natl. Acad. Sci. U.S.A. 89:3070-3074(1992)

PubMed=7954422
Steven W. Johnson, Pamela A. Swiggard, Laura M. Handel, James M. Brennan, Andrew Kent Godwin, Robert F. Ozols, Thomas C. Hamilton;
Relationship between platinum-DNA adduct formation and removal and cisplatin cytotoxicity in cisplatin-sensitive and -resistant human ovarian cancer cells.
Cancer Res. 54:5911-5916(1994)

PubMed=9554442; DOI=10.1093/jnci/90.8.597
Anita Lyn Sabichi, Denver T. Hendricks, Mary A. Bober, Michael J. Birrer;
Retinoic acid receptor beta expression and growth inhibition of gynecologic cancer cells by the synthetic retinoid N-(4-hydroxyphenyl) retinamide.
J. Natl. Cancer Inst. 90:597-605(1998)

PubMed=12080474; DOI=10.1038/sj.onc.1205542
Ramon G. Manzano, Luis M. Montuenga, Mark A. Dayton, Paul Dent, Ichiro Kinoshita, Silvestre Vicent, Ginger J. Gardner, PhuongMai Nguyen, Yung-Hyun Choi, Jane B. Trepel, Nelly Auersperg, Michael J. Birrer;
CL100 expression is down-regulated in advanced epithelial ovarian cancer and its re-expression decreases its malignant potential.
Oncogene 21:4435-4447(2002)

PubMed=17254797; DOI=10.1016/j.biologicals.2006.10.001
Shahram Azari, Nahid Ahmadi, Mahmood Jeddi-Tehrani, Fazel Shokri;
Profiling and authentication of human cell lines using short tandem repeat (STR) loci: report from the National Cell Bank of Iran.
Biologicals 35:195-202(2007)

PubMed=19926575; DOI=10.1309/AJCPTK87EMMIKPFS; PMCID=PMC3040237
Melissa S. DeRycke, John D. Andersen, Katherine M. Harrington, Stefan Eduard Pambuccian, Steve E. Kalloger, Kristin L.M. Boylan, Peter Alexander Argenta, Amy Patrice Norden Skubitz;
S100A1 expression in ovarian and endometrial endometrioid carcinomas is a prognostic indicator of relapse-free survival.
Am. J. Clin. Pathol. 132:846-856(2009)

PubMed=27561551; DOI=10.1038/ncomms12645; PMCID=PMC5007461
Fabian Coscia, Karen M. Watters, Marion Curtis, Mark A. Eckert, Chun-Yi Chiang, Stefka Tyanova, Anthony Montag, Ricardo R. Lastra, Ernst Robert Lengyel, Matthias Mann;
Integrative proteomic profiling of ovarian cancer cell lines reveals precursor cell associated proteins and functional status.
Nat. Commun. 7:12645.1-12645.14(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=28546799; DOI=10.1186/s12014-017-9155-z; PMCID=PMC5442857
Ran Zhao, Wen-Jun Qin, Rui-Huan Qin, Jing Han, Can Li, Yi-Sheng Wang, Cong-Jian Xu;
Lectin array and glycogene expression analyses of ovarian cancer cell line A2780 and its cisplatin-resistant derivate cell line A2780-cp.
Clin. Proteomics 14:20.1-20.10(2017)

Cross-references
Cell line collections (Providers) NCBI_Iran; C454
Cell line databases/resources MCCL; MCC:0000028
cancercelllines; CVCL_0135
Anatomy/cell type resources BTO; BTO_0003845
Encyclopedic resources Wikidata; Q54606604
Gene expression databases GEO; GSM184400
GEO; GSM184401
GEO; GSM743511
GEO; GSM851908
GEO; GSM1178064
GEO; GSM1178065
Polymorphism and mutation databases Progenetix; CVCL_0135
Proteomic databases PRIDE; PXD003668
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number30