| Cell line name |
A2780/100 |
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| Synonyms |
A2780(100) |
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| Accession |
CVCL_7224 |
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| Resource Identification Initiative |
To cite this cell line use: A2780/100 (RRID:CVCL_7224) |
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| Comments |
Population: African American.
Selected for resistance to: ChEBI; CHEBI_28830; Chlorambucil (CBL; Leukeran).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992. |
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| Sequence variations |
- Mutation; HGNC; HGNC:795; ATM; Simple; p.Pro604Ser (c.1810C>T); ClinVar=VCV000127343; Zygosity=Unspecified (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu365Lys (c.1093G>A); ClinVar=VCV000419222; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys128_Arg130del (c.383_391del9); Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:17271; RRAS2; Simple; p.Gln72Leu (c.215A>T); ClinVar=VCV000009447; Zygosity=Homozygous (from parent cell line).
|
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| Disease |
Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Endometrioid carcinoma of ovary (ORDO: Orphanet_454723) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0134 (A2780) |
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| Sex of cell |
Female |
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| Age at sampling |
Age unspecified |
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| Category |
Cancer cell line |
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| Publications | PubMed=10413308; DOI=10.1016/S0006-2952(99)00142-2
Julie K. Horton, Gargi Roy, John T. Piper, Bennett Van Houten, Yogesh C. Awasthi, Sankar Mitra, Moulay Abdellah Alaoui-Jamali, Istvan Boldogh, Sharad S. Singhal;
Characterization of a chlorambucil-resistant human ovarian carcinoma cell line overexpressing glutathione S-transferase mu.
Biochem. Pharmacol. 58:693-702(1999) PubMed=10644989; DOI=10.1038/sj.onc.1203318
Gargi Roy, Julie K. Horton, Rabindra Roy, Timothy Denning, Sankar Mitra, Istvan Boldogh;
Acquired alkylating drug resistance of a human ovarian carcinoma cell line is unaffected by altered levels of pro- and anti-apoptotic proteins.
Oncogene 19:141-150(2000) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_7224
|
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| Anatomy/cell type resources |
BTO; BTO_0003207
|
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| Encyclopedic resources |
Wikidata; Q54606583
|
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| Entry history |
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| Entry creation | 04-Apr-2012 |
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| Last entry update | 10-Apr-2025 |
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| Version number | 18 |
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