ID   A2780/100
AC   CVCL_7224
SY   A2780(100)
DR   BTO; BTO:0003207
DR   cancercelllines; CVCL_7224
DR   Wikidata; Q54606583
RX   PubMed=10413308;
RX   PubMed=10644989;
CC   Population: African American.
CC   Selected for resistance to: ChEBI; CHEBI:28830; Chlorambucil (CBL; Leukeran).
CC   Sequence variation: Mutation; HGNC; 795; ATM; Simple; p.Pro604Ser (c.1810C>T); ClinVar=VCV000127343; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Lys128_Arg130del (c.383_391del9); Zygosity=Unspecified (from parent cell line).
CC   Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
DI   NCIt; C7979; Ovarian endometrioid adenocarcinoma
DI   ORDO; Orphanet_454723; Endometrioid carcinoma of ovary
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0134 ! A2780
SX   Female
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 16
//
RX   PubMed=10413308; DOI=10.1016/S0006-2952(99)00142-2;
RA   Horton J.K., Roy G., Piper J.T., Van Houten B., Awasthi Y.C.,
RA   Mitra S., Alaoui-Jamali M.A., Boldogh I., Singhal S.S.;
RT   "Characterization of a chlorambucil-resistant human ovarian carcinoma
RT   cell line overexpressing glutathione S-transferase mu.";
RL   Biochem. Pharmacol. 58:693-702(1999).
//
RX   PubMed=10644989; DOI=10.1038/sj.onc.1203318;
RA   Roy G., Horton J.K., Roy R., Denning T., Mitra S., Boldogh I.;
RT   "Acquired alkylating drug resistance of a human ovarian carcinoma cell
RT   line is unaffected by altered levels of pro- and anti-apoptotic
RT   proteins.";
RL   Oncogene 19:141-150(2000).
//