| Cell line name |
A2780/C200 |
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| Synonyms |
C200 |
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| Accession |
CVCL_F638 |
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| Resource Identification Initiative |
To cite this cell line use: A2780/C200 (RRID:CVCL_F638) |
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| Comments |
Population: African American.
Selected for resistance to: ChEBI; CHEBI_27899; Cisplatin (CDDP).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992. |
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| Sequence variations |
- Mutation; HGNC; HGNC:795; ATM; Simple; p.Pro604Ser (c.1810C>T); ClinVar=VCV000127343; Zygosity=Unspecified (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu365Lys (c.1093G>A); ClinVar=VCV000419222; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys128_Arg130del (c.383_391del9); Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:17271; RRAS2; Simple; p.Gln72Leu (c.215A>T); ClinVar=VCV000009447; Zygosity=Homozygous (from parent cell line).
|
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| Disease |
Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Endometrioid carcinoma of ovary (ORDO: Orphanet_454723) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0134 (A2780) |
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| Sex of cell |
Female |
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| Age at sampling |
Age unspecified |
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| Category |
Cancer cell line |
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| Publications | PubMed=1348364; DOI=10.1073/pnas.89.7.3070; PMCID=PMC48805
Andrew Kent Godwin, Alton Meister, Peter J. O'Dwyer, Chin-Shiou Huang, Thomas C. Hamilton, Mary E. Anderson;
High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis.
Proc. Natl. Acad. Sci. U.S.A. 89:3070-3074(1992) PubMed=7954422
Steven W. Johnson, Pamela A. Swiggard, Laura M. Handel, James M. Brennan, Andrew Kent Godwin, Robert F. Ozols, Thomas C. Hamilton;
Relationship between platinum-DNA adduct formation and removal and cisplatin cytotoxicity in cisplatin-sensitive and -resistant human ovarian cancer cells.
Cancer Res. 54:5911-5916(1994) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_F638
|
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| Encyclopedic resources |
Wikidata; Q54606593
|
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| Gene expression databases |
GEO; GSM184394
GEO; GSM184395
|
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| Polymorphism and mutation databases |
Progenetix; CVCL_F638
|
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| Entry history |
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| Entry creation | 11-Feb-2013 |
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| Last entry update | 10-Apr-2025 |
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| Version number | 18 |
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