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Cellosaurus A2780-NiraR (CVCL_E5I4)

[Text version]
Cell line name A2780-NiraR
Accession CVCL_E5I4
Resource Identification Initiative To cite this cell line use: A2780-NiraR (RRID:CVCL_E5I4)
Comments Group: Patented cell line.
Registration: International Depositary Authority, China Center for Type Culture Collection; CCTCC C202299.
Population: African American.
Selected for resistance to: ChEBI; CHEBI_176844; Niraparib.
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Sequence variations
  • Mutation; HGNC; HGNC:795; ATM; Simple; p.Pro604Ser (c.1810C>T); ClinVar=VCV000127343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu365Lys (c.1093G>A); ClinVar=VCV000419222; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys128_Arg130del (c.383_391del9); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:17271; RRAS2; Simple; p.Gln72Leu (c.215A>T); ClinVar=VCV000009447; Zygosity=Homozygous (from parent cell line).
Disease Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Endometrioid carcinoma of ovary (ORDO: Orphanet_454723)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0134 (A2780)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

Patent=US20240263142
Lu W.-G., Lin H., Shen Y.-Q., Xu J.-F.
Human ovarian cancer niraparib-resistant cell strain and use thereof.
Patent number US20240263142, 08-Aug-2024

Cross-references
Cell line databases/resources CCRID; 4201PAT-CCTCC02086
Entry history
Entry creation10-Apr-2025
Last entry update10-Apr-2025
Version number1