| Cell line name |
A2780-TC1 |
|---|
| Synonyms |
A2780 TC1; A2780TC1; TC1 |
|---|
| Accession |
CVCL_1F93 |
|---|
| Resource Identification Initiative |
To cite this cell line use: A2780-TC1 (RRID:CVCL_1F93) |
|---|
| Comments |
Population: African American.
Selected for resistance to: ChEBI; CHEBI_45863; Paclitaxel (Taxol).
Omics: Proteomics; 2DE-MS.
Derived from site: In situ; Ovary; UBERON=UBERON_0000992. |
|---|
| Sequence variations |
- Mutation; HGNC; HGNC:795; ATM; Simple; p.Pro604Ser (c.1810C>T); ClinVar=VCV000127343; Zygosity=Unspecified (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu365Lys (c.1093G>A); ClinVar=VCV000419222; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys128_Arg130del (c.383_391del9); Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:17271; RRAS2; Simple; p.Gln72Leu (c.215A>T); ClinVar=VCV000009447; Zygosity=Homozygous (from parent cell line).
|
|---|
| Disease |
Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Endometrioid carcinoma of ovary (ORDO: Orphanet_454723) |
|---|
| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
|---|
| Hierarchy |
Parent: CVCL_0134 (A2780) |
|---|
| Sex of cell |
Female |
|---|
| Age at sampling |
Age unspecified |
|---|
| Category |
Cancer cell line |
|---|
| Publications | PubMed=12815160; DOI=10.1124/mol.64.1.51
Cristiano Ferlini, Giuseppina Raspaglio, Simona Mozzetti, Mariagrazia Distefano, Flavia Filippetti, Enrica Martinelli, Gabriella Ferrandina, Daniela Gallo, Franco Oreste Ranelletti, Giovanni Scambia;
Bcl-2 down-regulation is a novel mechanism of paclitaxel resistance.
Mol. Pharmacol. 64:51-58(2003) PubMed=19714814; DOI=10.1021/pr800856b
Lucia Cicchillitti, Michela Di Michele, Andrea Urbani, Cristiano Ferlini, Maria Benedetta Donati, Giovanni Scambia, Domenico Rotilio;
Comparative proteomic analysis of paclitaxel sensitive A2780 epithelial ovarian cancer cell line and its resistant counterpart A2780TC1 by 2D-DIGE: the role of ERp57.
J. Proteome Res. 8:1902-1912(2009) |
|---|
| Cross-references |
|---|
| Cell line databases/resources |
cancercelllines; CVCL_1F93
|
|---|
| Encyclopedic resources |
Wikidata; Q54606582
|
|---|
| Entry history |
|---|
| Entry creation | 08-Jul-2015 |
|---|
| Last entry update | 10-Apr-2025 |
|---|
| Version number | 14 |
|---|
