ID   A2780-TC1
AC   CVCL_1F93
SY   A2780 TC1; A2780TC1; TC1
DR   cancercelllines; CVCL_1F93
DR   Wikidata; Q54606582
RX   PubMed=12815160;
RX   PubMed=19714814;
CC   Population: African American.
CC   Selected for resistance to: ChEBI; CHEBI_45863; Paclitaxel (Taxol).
CC   Sequence variation: Mutation; HGNC; HGNC:795; ATM; Simple; p.Pro604Ser (c.1810C>T); ClinVar=VCV000127343; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu365Lys (c.1093G>A); ClinVar=VCV000419222; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys128_Arg130del (c.383_391del9); Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:17271; RRAS2; Simple; p.Gln72Leu (c.215A>T); ClinVar=VCV000009447; Zygosity=Homozygous (from parent cell line).
CC   Omics: Proteomics; 2DE-MS.
CC   Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
DI   NCIt; C7979; Ovarian endometrioid adenocarcinoma
DI   ORDO; Orphanet_454723; Endometrioid carcinoma of ovary
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0134 ! A2780
SX   Female
AG   Age unspecified
CA   Cancer cell line
DT   Created: 08-07-15; Last updated: 10-04-25; Version: 14
//
RX   PubMed=12815160; DOI=10.1124/mol.64.1.51;
RA   Ferlini C., Raspaglio G., Mozzetti S., Distefano M., Filippetti F.,
RA   Martinelli E., Ferrandina G., Gallo D., Ranelletti F.O., Scambia G.;
RT   "Bcl-2 down-regulation is a novel mechanism of paclitaxel
RT   resistance.";
RL   Mol. Pharmacol. 64:51-58(2003).
//
RX   PubMed=19714814; DOI=10.1021/pr800856b;
RA   Cicchillitti L., Di Michele M., Urbani A., Ferlini C., Donati M.B.,
RA   Scambia G., Rotilio D.;
RT   "Comparative proteomic analysis of paclitaxel sensitive A2780
RT   epithelial ovarian cancer cell line and its resistant counterpart
RT   A2780TC1 by 2D-DIGE: the role of ERp57.";
RL   J. Proteome Res. 8:1902-1912(2009).
//