ID   A2780-TC1
AC   CVCL_1F93
SY   A2780 TC1; A2780TC1; TC1
DR   cancercelllines; CVCL_1F93
DR   Wikidata; Q54606582
RX   PubMed=12815160;
RX   PubMed=19714814;
CC   Population: African American.
CC   Selected for resistance to: ChEBI; CHEBI_45863; Paclitaxel (Taxol).
CC   Sequence variation: Mutation; HGNC; HGNC:795; ATM; Simple; p.Pro604Ser (c.1810C>T); ClinVar=VCV000127343; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu365Lys (c.1093G>A); ClinVar=VCV000419222; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys128_Arg130del (c.383_391del9); Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:17271; RRAS2; Simple; p.Gln72Leu (c.215A>T); ClinVar=VCV000009447; Zygosity=Homozygous (from parent cell line).
CC   Omics: Proteomics; 2DE-MS.
CC   Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
DI   NCIt; C7979; Ovarian endometrioid adenocarcinoma
DI   ORDO; Orphanet_454723; Endometrioid carcinoma of ovary
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0134 ! A2780
SX   Female
AG   Age unspecified
CA   Cancer cell line
DT   Created: 08-07-15; Last updated: 10-04-25; Version: 14
//
RX   PubMed=12815160; DOI=10.1124/mol.64.1.51;
RA   Ferlini, Cristiano
RA   Raspaglio, Giuseppina
RA   Mozzetti, Simona
RA   Distefano, Mariagrazia
RA   Filippetti, Flavia
RA   Martinelli, Enrica
RA   Ferrandina, Gabriella
RA   Gallo, Daniela
RA   Ranelletti, Franco Oreste
RA   Scambia, Giovanni
RT   "Bcl-2 down-regulation is a novel mechanism of paclitaxel
RT   resistance.";
RL   Mol. Pharmacol. 64:51-58(2003).
//
RX   PubMed=19714814; DOI=10.1021/pr800856b;
RA   Cicchillitti, Lucia
RA   Di Michele, Michela
RA   Urbani, Andrea
RA   Ferlini, Cristiano
RA   Donati, Maria Benedetta
RA   Scambia, Giovanni
RA   Rotilio, Domenico
RT   "Comparative proteomic analysis of paclitaxel sensitive A2780
RT   epithelial ovarian cancer cell line and its resistant counterpart
RT   A2780TC1 by 2D-DIGE: the role of ERp57.";
RL   J. Proteome Res. 8:1902-1912(2009).
//