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Cellosaurus A2780/cDDP (CVCL_Y180)

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Cell line name A2780/cDDP
Accession CVCL_Y180
Resource Identification Initiative To cite this cell line use: A2780/cDDP (RRID:CVCL_Y180)
Comments Population: African American.
Selected for resistance to: ChEBI; CHEBI_27899; Cisplatin (CDDP).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Sequence variations
  • Mutation; HGNC; HGNC:795; ATM; Simple; p.Pro604Ser (c.1810C>T); ClinVar=VCV000127343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu365Lys (c.1093G>A); ClinVar=VCV000419222; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys128_Arg130del (c.383_391del9); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:17271; RRAS2; Simple; p.Gln72Leu (c.215A>T); ClinVar=VCV000009447; Zygosity=Homozygous (from parent cell line).
Disease Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Endometrioid carcinoma of ovary (ORDO: Orphanet_454723)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0134 (A2780)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=14973057; DOI=10.1158/0008-5472.CAN-3263-2
Kohichiroh Yasui, Saori Mihara, Chen Zhao, Hiroyuki Okamoto, Fumiko Saito-Ohara, Akihiro Tomida, Tadao Funato, Akira Yokomizo, Seiji Naito, Issei Imoto, Takashi Tsuruo, Johji Inazawa;
Alteration in copy numbers of genes as a mechanism for acquired drug resistance.
Cancer Res. 64:1403-1410(2004)

Cross-references
Cell line databases/resources cancercelllines; CVCL_Y180
CGH-DB; 9110-4
Encyclopedic resources Wikidata; Q54606601
Entry history
Entry creation07-Nov-2014
Last entry update10-Apr-2025
Version number13