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Cellosaurus A2780-1A9 (CVCL_H619)

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Cell line name A2780-1A9
Synonyms A2780/1A9; A2780(1A9); 1A9
Accession CVCL_H619
Resource Identification Initiative To cite this cell line use: A2780-1A9 (RRID:CVCL_H619)
Comments Population: African American.
Misspelling: IA9; Note=Occasionally.
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Sequence variations
  • Mutation; HGNC; HGNC:795; ATM; Simple; p.Pro604Ser (c.1810C>T); ClinVar=VCV000127343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu365Lys (c.1093G>A); ClinVar=VCV000419222; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys128_Arg130del (c.383_391del9); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:17271; RRAS2; Simple; p.Gln72Leu (c.215A>T); ClinVar=VCV000009447; Zygosity=Homozygous (from parent cell line).
Disease Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Endometrioid carcinoma of ovary (ORDO: Orphanet_454723)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0134 (A2780)
Children:
CVCL_B7S4 (1A9/CP10)CVCL_CZ93 (1A9/T80)CVCL_H620 (1A9PTX10)
CVCL_H622 (1A9PTX15)CVCL_H621 (1A9PTX22)CVCL_S476 (A2780-E(80))
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=1348364; DOI=10.1073/pnas.89.7.3070; PMCID=PMC48805
Andrew Kent Godwin, Alton Meister, Peter J. O'Dwyer, Chin-Shiou Huang, Thomas C. Hamilton, Mary E. Anderson;
High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis.
Proc. Natl. Acad. Sci. U.S.A. 89:3070-3074(1992)

PubMed=16382445; DOI=10.1002/gcc.20300
Yan C. Wang, Dejan Juric, Brian Francisco, Ron X. Yu, George E. Duran, G. Kevin Chen, Xin Chen, Branimir Ivan Sikic;
Regional activation of chromosomal arm 7q with and without gene amplification in taxane-selected human ovarian cancer cell lines.
Genes Chromosomes Cancer 45:365-374(2006)

Cross-references
Cell line databases/resources cancercelllines; CVCL_H619
Chemistry resources ChEMBL-Cells; CHEMBL3307529
ChEMBL-Targets; CHEMBL614075
PubChem_Cell_line; CVCL_H619
Encyclopedic resources Wikidata; Q54582664
Gene expression databases GEO; GSM95437
Polymorphism and mutation databases Progenetix; CVCL_H619
Entry history
Entry creation11-Feb-2013
Last entry update10-Apr-2025
Version number24