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Cellosaurus 1A9PTX10 (CVCL_H620)

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Cell line name 1A9PTX10
Synonyms 1A9/PTX10; 1A9/ptx-10; 1A9/Ptx-10; PTX10
Accession CVCL_H620
Resource Identification Initiative To cite this cell line use: 1A9PTX10 (RRID:CVCL_H620)
Comments Population: African American.
Selected for resistance to: ChEBI; CHEBI_45863; Paclitaxel (Taxol).
Misspelling: IA9-PTX10; Note=Occasionally.
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Sequence variations
  • Mutation; HGNC; HGNC:795; ATM; Simple; p.Pro604Ser (c.1810C>T); ClinVar=VCV000127343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu365Lys (c.1093G>A); ClinVar=VCV000419222; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys128_Arg130del (c.383_391del9); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:17271; RRAS2; Simple; p.Gln72Leu (c.215A>T); ClinVar=VCV000009447; Zygosity=Homozygous (from parent cell line).
Disease Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Endometrioid carcinoma of ovary (ORDO: Orphanet_454723)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_H619 (A2780-1A9)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Web pages Provider; Cornell TTO; -; https://cornell.flintbox.com/technologies/e7fac129-74ae-48d1-ab1c-9f087b79ddd7
Publications

PubMed=9202030; DOI=10.1074/jbc.272.27.17118
Paraskevi Giannakakou, Dan L. Sackett, Yoon-Koo Kang, Zhi-Rong Zhan, Jeroen Titus Maria Buters, Antonio Fojo, Marianne Sophie Poruchynsky;
Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulins that exhibit impaired paclitaxel-driven polymerization.
J. Biol. Chem. 272:17118-17125(1997)

PubMed=10871860; DOI=10.1038/sj.onc.1203642
Paraskevi Giannakakou, George Poy, Zhi-Rong Zhan, Turid Knutsen, Mikhail V. Blagosklonny, Antonio Fojo;
Paclitaxel selects for mutant or pseudo-null p53 in drug resistance associated with tubulin mutations in human cancer.
Oncogene 19:3078-3085(2000)

Cross-references
Cell line databases/resources cancercelllines; CVCL_H620
Chemistry resources ChEMBL-Cells; CHEMBL3307629
ChEMBL-Targets; CHEMBL614509
PubChem_Cell_line; CVCL_H620
Encyclopedic resources Wikidata; Q54582753
Entry history
Entry creation11-Feb-2013
Last entry update10-Apr-2025
Version number24