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Cellosaurus 1A9/T80 (CVCL_CZ93)

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Cell line name 1A9/T80
Synonyms 1A9 T80; 1A9T80
Accession CVCL_CZ93
Resource Identification Initiative To cite this cell line use: 1A9/T80 (RRID:CVCL_CZ93)
Comments Population: African American.
Selected for resistance to: ChEBI; CHEBI_45863; Paclitaxel (Taxol).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Sequence variations
  • Mutation; HGNC; HGNC:795; ATM; Simple; p.Pro604Ser (c.1810C>T); ClinVar=VCV000127343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu365Lys (c.1093G>A); ClinVar=VCV000419222; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys128_Arg130del (c.383_391del9); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:17271; RRAS2; Simple; p.Gln72Leu (c.215A>T); ClinVar=VCV000009447; Zygosity=Homozygous (from parent cell line).
Disease Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Endometrioid carcinoma of ovary (ORDO: Orphanet_454723)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_H619 (A2780-1A9)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=16382445; DOI=10.1002/gcc.20300
Yan C. Wang, Dejan Juric, Brian Francisco, Ron X. Yu, George E. Duran, G. Kevin Chen, Xin Chen, Branimir Ivan Sikic;
Regional activation of chromosomal arm 7q with and without gene amplification in taxane-selected human ovarian cancer cell lines.
Genes Chromosomes Cancer 45:365-374(2006)

Cross-references
Cell line databases/resources cancercelllines; CVCL_CZ93
Encyclopedic resources Wikidata; Q54582666
Gene expression databases GEO; GSM95438
Polymorphism and mutation databases Progenetix; CVCL_CZ93
Entry history
Entry creation13-Jul-2016
Last entry update10-Apr-2025
Version number13