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Cellosaurus 1A9PTX15 (CVCL_H622)

[Text version]
Cell line name 1A9PTX15
Synonyms PTX15
Accession CVCL_H622
Resource Identification Initiative To cite this cell line use: 1A9PTX15 (RRID:CVCL_H622)
Comments Population: African American.
Selected for resistance to: ChEBI; CHEBI:45863; Paclitaxel (Taxol).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Sequence variations
  • Mutation; HGNC; 795; ATM; Simple; p.Pro604Ser (c.1810C>T); ClinVar=VCV000127343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Lys128_Arg130del (c.383_391del9); Zygosity=Unspecified (from parent cell line).
Disease Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Endometrioid carcinoma of ovary (ORDO: Orphanet_454723)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_H619 (A2780-1A9)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=10871860; DOI=10.1038/sj.onc.1203642
Giannakakou P., Poy G., Zhan Z.-R., Knutsen T., Blagosklonny M.V., Fojo T.
Paclitaxel selects for mutant or pseudo-null p53 in drug resistance associated with tubulin mutations in human cancer.
Oncogene 19:3078-3085(2000)

Cross-references
Cell line databases/resources cancercelllines; CVCL_H622
Encyclopedic resources Wikidata; Q54582754
Entry history
Entry creation11-Feb-2013
Last entry update05-Oct-2023
Version number16