| Cell line name |
A2780/CBP |
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| Synonyms |
A-car |
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| Accession |
CVCL_D620 |
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| Resource Identification Initiative |
To cite this cell line use: A2780/CBP (RRID:CVCL_D620) |
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| Comments |
Population: African American.
Selected for resistance to: ChEBI; CHEBI_31355; Carboplatin (CBP; Paraplatin).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992. |
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| Sequence variations |
- Mutation; HGNC; HGNC:795; ATM; Simple; p.Pro604Ser (c.1810C>T); ClinVar=VCV000127343; Zygosity=Unspecified (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu365Lys (c.1093G>A); ClinVar=VCV000419222; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys128_Arg130del (c.383_391del9); Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:17271; RRAS2; Simple; p.Gln72Leu (c.215A>T); ClinVar=VCV000009447; Zygosity=Homozygous (from parent cell line).
|
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| Disease |
Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Endometrioid carcinoma of ovary (ORDO: Orphanet_454723) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0134 (A2780) |
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| Sex of cell |
Female |
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| Age at sampling |
Age unspecified |
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| Category |
Cancer cell line |
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| Publications | PubMed=15254775; DOI=10.3892/ijmm.14.2.257
Li Li, Ying-Zi Luan, Gang-Duo Wang, Bu-Jian Tang, Dan-Rong Li, Wei Zhang, Xi-Ping Li, Jin-Shun Zhao, Hong Ding, Eddie Reed, Qing-Di Q. Li;
Development and characterization of five cell models for chemoresistance studies of human ovarian carcinoma.
Int. J. Mol. Med. 14:257-264(2004) PubMed=17269733; DOI=10.1021/pr060402r
Xue-Dong Yan, Ling-Ya Pan, Ye Yuan, Jing-He Lang, Ning Mao;
Identification of platinum-resistance associated proteins through proteomic analysis of human ovarian cancer cells and their platinum-resistant sublines.
J. Proteome Res. 6:772-780(2007) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_D620
|
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| Encyclopedic resources |
Wikidata; Q54606598
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| Entry history |
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| Entry creation | 22-Oct-2012 |
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| Last entry update | 10-Apr-2025 |
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| Version number | 17 |
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