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Cellosaurus 2780AD (CVCL_C9BP)

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Cell line name 2780AD
Accession CVCL_C9BP
Resource Identification Initiative To cite this cell line use: 2780AD (RRID:CVCL_C9BP)
Comments Population: African American.
Selected for resistance to: ChEBI; CHEBI_28748; Doxorubicin (Adriablastin; Adriamycin).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Sequence variations
  • Mutation; HGNC; HGNC:795; ATM; Simple; p.Pro604Ser (c.1810C>T); ClinVar=VCV000127343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu365Lys (c.1093G>A); ClinVar=VCV000419222; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys128_Arg130del (c.383_391del9); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:17271; RRAS2; Simple; p.Gln72Leu (c.215A>T); ClinVar=VCV000009447; Zygosity=Homozygous (from parent cell line).
Disease Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Endometrioid carcinoma of ovary (ORDO: Orphanet_454723)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0134 (A2780)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=6372095; DOI=10.1126/science.6372095
Alfred M. Rogan, Thomas C. Hamilton, Robert C. Young, Raymond W. Klecker Jr., Robert F. Ozols;
Reversal of adriamycin resistance by verapamil in human ovarian cancer.
Science 224:994-996(1984)

Cross-references
Encyclopedic resources Wikidata; Q123030245
Entry history
Entry creation05-Oct-2023
Last entry update10-Apr-2025
Version number4