| Cell line name |
A2780-DX1 |
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| Accession |
CVCL_4T95 |
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| Resource Identification Initiative |
To cite this cell line use: A2780-DX1 (RRID:CVCL_4T95) |
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| Comments |
Population: African American.
Selected for resistance to: ChEBI; CHEBI_28748; Doxorubicin (Adriablastin; Adriamycin).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992. |
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| Sequence variations |
- Mutation; HGNC; HGNC:795; ATM; Simple; p.Pro604Ser (c.1810C>T); ClinVar=VCV000127343; Zygosity=Unspecified (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu365Lys (c.1093G>A); ClinVar=VCV000419222; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys128_Arg130del (c.383_391del9); Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:17271; RRAS2; Simple; p.Gln72Leu (c.215A>T); ClinVar=VCV000009447; Zygosity=Homozygous (from parent cell line).
|
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| Disease |
Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Endometrioid carcinoma of ovary (ORDO: Orphanet_454723) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0134 (A2780)
Children:
|
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| Sex of cell |
Female |
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| Age at sampling |
Age unspecified |
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| Category |
Cancer cell line |
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| Publications | PubMed=2598402; DOI=10.1007/BF00692343
Moulay Abdellah Alaoui-Jamali, Ming-Biao Yin, Alessandra Mazzoni, Issam Bankusli, Youcef M. Rustum;
Relationship between cytotoxicity, drug accumulation, DNA damage and repair of human ovarian cancer cells treated with doxorubicin: modulation by the tiapamil analog RO11-2933.
Cancer Chemother. Pharmacol. 25:77-83(1989) PubMed=2243668; DOI=10.1159/000226878
Alessandra Mazzoni, Fabio Trave, Patrizia Russo, Angelo Nicolin, Youcef M. Rustum;
Generation and characterization of a low-degree drug-resistant human tumor cell line.
Oncology 47:488-494(1990) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_4T95
|
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| Encyclopedic resources |
Wikidata; Q54606565
|
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| Entry history |
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| Entry creation | 22-Sep-2015 |
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| Last entry update | 10-Apr-2025 |
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| Version number | 13 |
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