Cellosaurus cell line A2780-DX2 (CVCL

Cellosaurus A2780-DX2 (CVCL_4T96)

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Cell line name

A2780-DX2

Accession

CVCL_4T96

Resource Identification Initiative

To cite this cell line use: A2780-DX2 (RRID:CVCL_4T96)

Comments

Population: African American.
Selected for resistance to: ChEBI; CHEBI_28748; Doxorubicin (Adriablastin; Adriamycin).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.

Sequence variations

Mutation; HGNC; HGNC:795; ATM; Simple; p.Pro604Ser (c.1810C>T); ClinVar=VCV000127343; Zygosity=Unspecified (from parent cell line).
Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu365Lys (c.1093G>A); ClinVar=VCV000419222; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys128_Arg130del (c.383_391del9); Zygosity=Homozygous (from parent cell line).
Mutation; HGNC; HGNC:17271; RRAS2; Simple; p.Gln72Leu (c.215A>T); ClinVar=VCV000009447; Zygosity=Homozygous (from parent cell line).

Disease

Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Endometrioid carcinoma of ovary (ORDO: Orphanet_454723)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_4T95 (A2780-DX1)
Children:

CVCL_7225 (A2780-DX3)

Sex of cell

Female

Age at sampling

Age unspecified