Cell line name |
A2780-DX3 |
Synonyms |
A2780/DX3; A2780 DX3; DX3 |
Accession |
CVCL_7225 |
Resource Identification Initiative |
To cite this cell line use: A2780-DX3 (RRID:CVCL_7225) |
Comments |
Population: African American. Selected for resistance to: ChEBI; CHEBI_28748; Doxorubicin (Adriablastin; Adriamycin). Derived from site: In situ; Ovary; UBERON=UBERON_0000992. |
Sequence variations |
- Mutation; HGNC; HGNC:795; ATM; Simple; p.Pro604Ser (c.1810C>T); ClinVar=VCV000127343; Zygosity=Unspecified (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu365Lys (c.1093G>A); ClinVar=VCV000419222; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys128_Arg130del (c.383_391del9); Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:17271; RRAS2; Simple; p.Gln72Leu (c.215A>T); ClinVar=VCV000009447; Zygosity=Homozygous (from parent cell line).
|
Disease |
Ovarian endometrioid adenocarcinoma (NCIt: C7979) Endometrioid carcinoma of ovary (ORDO: Orphanet_454723) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_4T96 (A2780-DX2) Children:
|
Sex of cell |
Female |
Age at sampling |
Age unspecified |
Category |
Cancer cell line |
Publications | PubMed=2598402; DOI=10.1007/BF00692343 Moulay Abdellah Alaoui-Jamali, Ming-Biao Yin, Alessandra Mazzoni, Issam Bankusli, Youcef M. Rustum; Relationship between cytotoxicity, drug accumulation, DNA damage and repair of human ovarian cancer cells treated with doxorubicin: modulation by the tiapamil analog RO11-2933. Cancer Chemother. Pharmacol. 25:77-83(1989) PubMed=2751261 Alessandra Mazzoni, Fabio Trave, Gianfranco Canti, Paola Franco; Effect of the tiapamil analog RO11-2933 on cellular sensitivity to antitumor drugs in sensitive and multidrug resistant human ovarian cancer cells. Anticancer Res. 9:367-371(1989) PubMed=8012063 Guido Cimoli, Monica Valenti, Silvio Parodi, Alessandra Mazzoni, Fabio De Sessa, PierFranco Conte, Patrizia Russo; Reversal of 'atypical'-multidrug resistance by recombinant human tumor necrosis factor in the human ovarian cancer cell line A2780-DX3. Oncol. Res. 5:311-323(1993) PubMed=7713987; DOI=10.1007/BF01198097 Guido Cimoli, Monica Valenti, Elvira Noviello, Silvio Parodi, Alessandra Mazzoni, Elisabetta Rovini, Fabio De Sessa, Patrizia Russo; 'Atypical' multidrug resistance in human ovarian cancer cell line A2780 selected for resistance to doxorubicin (A2780 DX3). J. Cancer Res. Clin. Oncol. 121:155-163(1995) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_7225
|
Anatomy/cell type resources |
BTO; BTO_0002642
|
Encyclopedic resources |
Wikidata; Q54606570
|
Entry history |
Entry creation | 04-Apr-2012 |
Last entry update | 10-Apr-2025 |
Version number | 19 |
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