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Cellosaurus A2780-DX3 (CVCL_7225)

[Text version]
Cell line name A2780-DX3
Synonyms A2780/DX3; A2780 DX3; DX3
Accession CVCL_7225
Resource Identification Initiative To cite this cell line use: A2780-DX3 (RRID:CVCL_7225)
Comments Population: African American.
Selected for resistance to: ChEBI; CHEBI_28748; Doxorubicin (Adriablastin; Adriamycin).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Sequence variations
  • Mutation; HGNC; HGNC:795; ATM; Simple; p.Pro604Ser (c.1810C>T); ClinVar=VCV000127343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu365Lys (c.1093G>A); ClinVar=VCV000419222; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys128_Arg130del (c.383_391del9); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:17271; RRAS2; Simple; p.Gln72Leu (c.215A>T); ClinVar=VCV000009447; Zygosity=Homozygous (from parent cell line).
Disease Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Endometrioid carcinoma of ovary (ORDO: Orphanet_454723)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4T96 (A2780-DX2)
Children:
CVCL_4T97 (A2780-DX4)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=2598402; DOI=10.1007/BF00692343
Moulay Abdellah Alaoui-Jamali, Ming-Biao Yin, Alessandra Mazzoni, Issam Bankusli, Youcef M. Rustum;
Relationship between cytotoxicity, drug accumulation, DNA damage and repair of human ovarian cancer cells treated with doxorubicin: modulation by the tiapamil analog RO11-2933.
Cancer Chemother. Pharmacol. 25:77-83(1989)

PubMed=2751261
Alessandra Mazzoni, Fabio Trave, Gianfranco Canti, Paola Franco;
Effect of the tiapamil analog RO11-2933 on cellular sensitivity to antitumor drugs in sensitive and multidrug resistant human ovarian cancer cells.
Anticancer Res. 9:367-371(1989)

PubMed=8012063
Guido Cimoli, Monica Valenti, Silvio Parodi, Alessandra Mazzoni, Fabio De Sessa, PierFranco Conte, Patrizia Russo;
Reversal of 'atypical'-multidrug resistance by recombinant human tumor necrosis factor in the human ovarian cancer cell line A2780-DX3.
Oncol. Res. 5:311-323(1993)

PubMed=7713987; DOI=10.1007/BF01198097
Guido Cimoli, Monica Valenti, Elvira Noviello, Silvio Parodi, Alessandra Mazzoni, Elisabetta Rovini, Fabio De Sessa, Patrizia Russo;
'Atypical' multidrug resistance in human ovarian cancer cell line A2780 selected for resistance to doxorubicin (A2780 DX3).
J. Cancer Res. Clin. Oncol. 121:155-163(1995)

Cross-references
Cell line databases/resources cancercelllines; CVCL_7225
Anatomy/cell type resources BTO; BTO_0002642
Encyclopedic resources Wikidata; Q54606570
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number19