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Cellosaurus A2780-DX3 (CVCL_7225)

[Text version]
Cell line name A2780-DX3
Synonyms A2780/DX3; A2780 DX3; DX3
Accession CVCL_7225
Resource Identification Initiative To cite this cell line use: A2780-DX3 (RRID:CVCL_7225)
Comments Population: African American.
Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Sequence variations
  • Mutation; HGNC; 795; ATM; Simple; p.Pro604Ser (c.1810C>T); ClinVar=VCV000127343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Lys128_Arg130del (c.383_391del9); Zygosity=Unspecified (from parent cell line).
Disease Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Endometrioid carcinoma of ovary (ORDO: Orphanet_454723)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4T96 (A2780-DX2)
Children:
CVCL_4T97 (A2780-DX4)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=2598402; DOI=10.1007/BF00692343
Alaoui-Jamali M.A., Yin M.-B., Mazzoni A., Bankusli I., Rustum Y.M.
Relationship between cytotoxicity, drug accumulation, DNA damage and repair of human ovarian cancer cells treated with doxorubicin: modulation by the tiapamil analog RO11-2933.
Cancer Chemother. Pharmacol. 25:77-83(1989)

PubMed=2751261
Mazzoni A., Trave F., Canti G., Franco P.
Effect of the tiapamil analog RO11-2933 on cellular sensitivity to antitumor drugs in sensitive and multidrug resistant human ovarian cancer cells.
Anticancer Res. 9:367-371(1989)

PubMed=8012063
Cimoli G., Valenti M., Parodi S., Mazzoni A., De Sessa F., Conte P., Russo P.
Reversal of 'atypical'-multidrug resistance by recombinant human tumor necrosis factor in the human ovarian cancer cell line A2780-DX3.
Oncol. Res. 5:311-323(1993)

PubMed=7713987; DOI=10.1007/BF01198097
Cimoli G., Valenti M., Noviello E., Parodi S., Mazzoni A., Rovini E., De Sessa F., Russo P.
'Atypical' multidrug resistance in human ovarian cancer cell line A2780 selected for resistance to doxorubicin (A2780 DX3).
J. Cancer Res. Clin. Oncol. 121:155-163(1995)

Cross-references
Cell line databases/resources cancercelllines; CVCL_7225
Anatomy/cell type resources BTO; BTO:0002642
Encyclopedic resources Wikidata; Q54606570
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number17