ID   A2780-DX3
AC   CVCL_7225
SY   A2780/DX3; A2780 DX3; DX3
DR   BTO; BTO_0002642
DR   cancercelllines; CVCL_7225
DR   Wikidata; Q54606570
RX   PubMed=2598402;
RX   PubMed=2751261;
RX   PubMed=7713987;
RX   PubMed=8012063;
CC   Population: African American.
CC   Selected for resistance to: ChEBI; CHEBI_28748; Doxorubicin (Adriablastin; Adriamycin).
CC   Sequence variation: Mutation; HGNC; HGNC:795; ATM; Simple; p.Pro604Ser (c.1810C>T); ClinVar=VCV000127343; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu365Lys (c.1093G>A); ClinVar=VCV000419222; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys128_Arg130del (c.383_391del9); Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:17271; RRAS2; Simple; p.Gln72Leu (c.215A>T); ClinVar=VCV000009447; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
DI   NCIt; C7979; Ovarian endometrioid adenocarcinoma
DI   ORDO; Orphanet_454723; Endometrioid carcinoma of ovary
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_4T96 ! A2780-DX2
SX   Female
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 19
//
RX   PubMed=2598402; DOI=10.1007/BF00692343;
RA   Alaoui-Jamali M.A., Yin M.-B., Mazzoni A., Bankusli I., Rustum Y.M.;
RT   "Relationship between cytotoxicity, drug accumulation, DNA damage and
RT   repair of human ovarian cancer cells treated with doxorubicin:
RT   modulation by the tiapamil analog RO11-2933.";
RL   Cancer Chemother. Pharmacol. 25:77-83(1989).
//
RX   PubMed=2751261;
RA   Mazzoni A., Trave F., Canti G., Franco P.;
RT   "Effect of the tiapamil analog RO11-2933 on cellular sensitivity to
RT   antitumor drugs in sensitive and multidrug resistant human ovarian
RT   cancer cells.";
RL   Anticancer Res. 9:367-371(1989).
//
RX   PubMed=7713987; DOI=10.1007/BF01198097;
RA   Cimoli G., Valenti M., Noviello E., Parodi S., Mazzoni A., Rovini E.,
RA   De Sessa F., Russo P.;
RT   "'Atypical' multidrug resistance in human ovarian cancer cell line
RT   A2780 selected for resistance to doxorubicin (A2780 DX3).";
RL   J. Cancer Res. Clin. Oncol. 121:155-163(1995).
//
RX   PubMed=8012063;
RA   Cimoli G., Valenti M., Parodi S., Mazzoni A., De Sessa F., Conte P.,
RA   Russo P.;
RT   "Reversal of 'atypical'-multidrug resistance by recombinant human
RT   tumor necrosis factor in the human ovarian cancer cell line
RT   A2780-DX3.";
RL   Oncol. Res. 5:311-323(1993).
//