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Cellosaurus A2780/Taxol (CVCL_IJ13)

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Cell line name A2780/Taxol
Synonyms A2780/T
Accession CVCL_IJ13
Resource Identification Initiative To cite this cell line use: A2780/Taxol (RRID:CVCL_IJ13)
Comments Population: African American.
Doubling time: 24.22 +- 0.22 hours (PubMed=24175763).
Selected for resistance to: ChEBI; CHEBI_45863; Paclitaxel (Taxol).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Sequence variations
  • Mutation; HGNC; HGNC:795; ATM; Simple; p.Pro604Ser (c.1810C>T); ClinVar=VCV000127343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu365Lys (c.1093G>A); ClinVar=VCV000419222; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys128_Arg130del (c.383_391del9); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:17271; RRAS2; Simple; p.Gln72Leu (c.215A>T); ClinVar=VCV000009447; Zygosity=Homozygous (from parent cell line).
Disease Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Endometrioid carcinoma of ovary (ORDO: Orphanet_454723)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0134 (A2780)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=24175763; DOI=10.7314/APJCP.2013.14.9.4983
Ning-Ning Wang, Li-Jun Zhao, Li-Nan Wu, Ming-Feng He, Jun-Wei Qu, Yi-Bing Zhao, Wan-Zhou Zhao, Jie-Shou Li, Jin-Hua Wang;
Mechanistic analysis of taxol-induced multidrug resistance in an ovarian cancer cell line.
Asian Pac. J. Cancer Prev. 14:4983-4988(2013)

Cross-references
Cell line databases/resources cancercelllines; CVCL_IJ13
Chemistry resources ChEMBL-Cells; CHEMBL4483130
ChEMBL-Targets; CHEMBL4483224
Encyclopedic resources Wikidata; Q54606608
Entry history
Entry creation01-Dec-2016
Last entry update10-Apr-2025
Version number14