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Cellosaurus A2780/cmv (CVCL_A5AB)

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Cell line name A2780/cmv
Accession CVCL_A5AB
Resource Identification Initiative To cite this cell line use: A2780/cmv (RRID:CVCL_A5AB)
Comments Population: African American.
Characteristics: Control cell line for A2780/m175 (Cellosaurus=CVCL_A5AC), A2780/m248 (Cellosaurus=CVCL_A5AD) and A2780/m273 (Cellosaurus=CVCL_A5AE) (PubMed=9924699).
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Sequence variations
  • Mutation; HGNC; HGNC:795; ATM; Simple; p.Pro604Ser (c.1810C>T); ClinVar=VCV000127343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu365Lys (c.1093G>A); ClinVar=VCV000419222; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys128_Arg130del (c.383_391del9); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:17271; RRAS2; Simple; p.Gln72Leu (c.215A>T); ClinVar=VCV000009447; Zygosity=Homozygous (from parent cell line).
Disease Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Endometrioid carcinoma of ovary (ORDO: Orphanet_454723)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0134 (A2780)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=9924699; DOI=10.1097/00002371-199901000-00007
Stefan Sleijfer, T.K. Phuong Le, Steven de Jong, Hetty Timmer-Bosscha, Sebo Withoff, Nanno H. Mulder;
Combined cytotoxic effects of tumor necrosis factor-alpha with various cytotoxic agents in tumor cell lines that are drug resistant due to mutated p53.
J. Immunother. 22:48-53(1999)

PubMed=12093475; DOI=10.1016/S0006-2952(02)00983-8
Eelco Fokkema, Harry J.M. Groen, Marco N. Helder, Elisabeth Geertruida Emma de Vries, Coby Meijer;
JM216-, JM118-, and cisplatin-induced cytotoxicity in relation to platinum-DNA adduct formation, glutathione levels and p53 status in human tumour cell lines with different sensitivities to cisplatin.
Biochem. Pharmacol. 63:1989-1996(2002)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A5AB
Encyclopedic resources Wikidata; Q107113314
Entry history
Entry creation20-May-2021
Last entry update14-Aug-2025
Version number10