| Cell line name |
A2780AD |
|---|
| Synonyms |
A2780/AD |
|---|
| Accession |
CVCL_UJ39 |
|---|
| Resource Identification Initiative |
To cite this cell line use: A2780AD (RRID:CVCL_UJ39) |
|---|
| Comments |
Population: African American.
Selected for resistance to: ChEBI; CHEBI_28748; Doxorubicin (Adriablastin; Adriamycin).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992. |
|---|
| Sequence variations |
- Mutation; HGNC; HGNC:795; ATM; Simple; p.Pro604Ser (c.1810C>T); ClinVar=VCV000127343; Zygosity=Unspecified (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu365Lys (c.1093G>A); ClinVar=VCV000419222; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys128_Arg130del (c.383_391del9); Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:17271; RRAS2; Simple; p.Gln72Leu (c.215A>T); ClinVar=VCV000009447; Zygosity=Homozygous (from parent cell line).
|
|---|
| Disease |
Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Endometrioid carcinoma of ovary (ORDO: Orphanet_454723) |
|---|
| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
|---|
| Hierarchy |
Parent: CVCL_0134 (A2780) |
|---|
| Sex of cell |
Female |
|---|
| Age at sampling |
Age unspecified |
|---|
| Category |
Cancer cell line |
|---|
| Publications | PubMed=2429947; DOI=10.20772/cancersci1985.77.9_941
Takashi Tsuruo, Thomas C. Hamilton, Karen Guigere Louie, Brent C. Behrens, Robert C. Young, Robert F. Ozols;
Collateral susceptibility of adriamycin-, melphalan- and cisplatin-resistant human ovarian tumor cells to bleomycin.
Jpn. J. Cancer Res. 77:941-945(1986) PubMed=7927910; DOI=10.1002/ijc.2910590118
Ian M. Huxham, Andrew L. Barlow, Alexander D. Lewis, Jane Plumb, Robert J. Mairs, Mark N. Gaze, Paul Workman;
Differential intracellular processing of the anthracycline drug ME2303 in doxorubicin-sensitive (A2780) and -resistant (A2780AD) human ovarian cancer cells as studied with confocal laser scanning microscopy and image analysis.
Int. J. Cancer 59:94-102(1994) |
|---|
| Cross-references |
|---|
| Cell line databases/resources |
cancercelllines; CVCL_UJ39
|
|---|
| Anatomy/cell type resources |
BTO; BTO_0006326
|
|---|
| Encyclopedic resources |
Wikidata; Q93311635
|
|---|
| Entry history |
|---|
| Entry creation | 25-Feb-2019 |
|---|
| Last entry update | 10-Apr-2025 |
|---|
| Version number | 10 |
|---|
