| Cell line name |
A2780/CP20 |
|---|
| Synonyms |
A2780(CP20); A2780-CP-20; A2780CP20 |
|---|
| Accession |
CVCL_A5PS |
|---|
| Resource Identification Initiative |
To cite this cell line use: A2780/CP20 (RRID:CVCL_A5PS) |
|---|
| Comments |
Population: African American.
Selected for resistance to: ChEBI; CHEBI_27899; Cisplatin (CDDP).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992. |
|---|
| Sequence variations |
- Mutation; HGNC; HGNC:795; ATM; Simple; p.Pro604Ser (c.1810C>T); ClinVar=VCV000127343; Zygosity=Unspecified (from parent cell line).
- Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu365Lys (c.1093G>A); ClinVar=VCV000419222; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys128_Arg130del (c.383_391del9); Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:17271; RRAS2; Simple; p.Gln72Leu (c.215A>T); ClinVar=VCV000009447; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val173Phe (c.517G>T); Zygosity=Unspecified (PubMed=8557231).
|
|---|
| Disease |
Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Endometrioid carcinoma of ovary (ORDO: Orphanet_454723) |
|---|
| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
|---|
| Hierarchy |
Parent: CVCL_0134 (A2780) |
|---|
| Sex of cell |
Female |
|---|
| Age at sampling |
Age unspecified |
|---|
| Category |
Cancer cell line |
|---|
| Publications | PubMed=3539322
Behrens B.C., Hamilton T.C., Masuda H., Grotzinger K.R., Whang-Peng J., Louie K.G., Knutsen T., McKoy W.M., Young R.C., Ozols R.F.
Characterization of a cis-diamminedichloroplatinum(II)-resistant human ovarian cancer cell line and its use in evaluation of platinum analogues.
Cancer Res. 47:414-418(1987) PubMed=8557231; DOI=10.1006/gyno.1996.0014
Skilling J.S., Squatrito R.C., Connor J.P., Niemann T., Buller R.E.
p53 gene mutation analysis and antisense-mediated growth inhibition of human ovarian carcinoma cell lines.
Gynecol. Oncol. 60:72-80(1996) |
|---|
| Cross-references |
|---|
| Cell line databases/resources |
cancercelllines; CVCL_A5PS
|
|---|
| Encyclopedic resources |
Wikidata; Q107113315
|
|---|
| Polymorphism and mutation databases |
IARC_TP53; 5551
|
|---|
| Entry history |
|---|
| Entry creation | 20-May-2021 |
|---|
| Last entry update | 10-Apr-2025 |
|---|
| Version number | 7 |
|---|
