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Cellosaurus A2780/CP20 (CVCL_A5PS)

[Text version]
Cell line name A2780/CP20
Synonyms A2780(CP20); A2780-CP-20; A2780CP20
Accession CVCL_A5PS
Resource Identification Initiative To cite this cell line use: A2780/CP20 (RRID:CVCL_A5PS)
Comments Population: African American.
Selected for resistance to: ChEBI; CHEBI:27899; Cisplatin (CDDP).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Sequence variations
  • Mutation; HGNC; 795; ATM; Simple; p.Pro604Ser (c.1810C>T); ClinVar=VCV000127343; Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Lys128_Arg130del (c.383_391del9); Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Val173Phe (c.517G>T); Zygosity=Unspecified (PubMed=8557231).
Disease Ovarian endometrioid adenocarcinoma (NCIt: C7979)
Endometrioid carcinoma of ovary (ORDO: Orphanet_454723)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0134 (A2780)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
Publications

PubMed=3539322
Behrens B.C., Hamilton T.C., Masuda H., Grotzinger K.R., Whang-Peng J., Louie K.G., Knutsen T., McKoy W.M., Young R.C., Ozols R.F.
Characterization of a cis-diamminedichloroplatinum(II)-resistant human ovarian cancer cell line and its use in evaluation of platinum analogues.
Cancer Res. 47:414-418(1987)

PubMed=8557231; DOI=10.1006/gyno.1996.0014
Skilling J.S., Squatrito R.C., Connor J.P., Niemann T., Buller R.E.
p53 gene mutation analysis and antisense-mediated growth inhibition of human ovarian carcinoma cell lines.
Gynecol. Oncol. 60:72-80(1996)

Cross-references
Cell line databases/resources cancercelllines; CVCL_A5PS
Encyclopedic resources Wikidata; Q107113315
Polymorphism and mutation databases IARC_TP53; 5551
Entry history
Entry creation20-May-2021
Last entry update05-Oct-2023
Version number5