Cellosaurus logo
expasy logo

Cellosaurus HT-1080 (CVCL_0317)

[Text version]
Cell line name HT-1080
Synonyms Ht-1080; HT 1080; HT1080; HT 1080.T
Accession CVCL_0317
Resource Identification Initiative To cite this cell line use: HT-1080 (RRID:CVCL_0317)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: ENCODE project common cell types; tier 3.
Part of: MD Anderson Cell Lines Project.
Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
Population: Caucasian.
Doubling time: 26 hours (PubMed=4132053); ~30 hours (DSMZ=ACC-315).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Misspelling: HT1180; Note=Occasionally.
Derived from site: In situ; Bone, pelvis, acetabulum; UBERON=UBERON_0001269.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (ATCC=CCL-121).
  • Mutation; HGNC; HGNC:5382; IDH1; Simple; p.Arg132Cys (c.394C>T); ClinVar=VCV000375891; Zygosity=Heterozygous (PubMed=26368816).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (PubMed=12068308; ATCC=CCL-121; Cosmic-CLP=907064; DepMap=ACH-000054).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*31:01,68:01
HLA-BB*27:05,27:05
HLA-CC*02:02,02:02

Source: CLS=300216
Class I
HLA-AA*31:01:02,68:01:01
HLA-BB*27:05:02
HLA-CC*02:02:02
Class II
HLA-DPDPB1*03:01,04:01
HLA-DQDQA1*03:03:01,05:01:01
DQB1*02:01:01,03:01:01
HLA-DRDRB1*03:01:01,04:07:01

Source: DSMZCellDive=ACC-315
Class I
HLA-AA*31:01:02,68:01:01
HLA-BB*27:05:02,27:05:02
HLA-CC*02:02:02,02:02:02
Class II
HLA-DPDPA1*01:03:01,01:03:01
DPB1*04:01:01,04:01:01
HLA-DRDRA*01:01:01,01:02:02
Genome ancestry Source: PubMed=30894373

Origin% genome
African0.86
Native American0.35
East Asian, North1.36
East Asian, South0.29
South Asian0
European, North68.21
European, South28.94
Disease Fibrosarcoma (NCIt: C3043)
Fibrosarcoma (ORDO: Orphanet_2030)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_1D50 (2C4 [Human fibrosarcoma])CVCL_0115 (2fTGH)CVCL_8870 (FLYA13)
CVCL_8871 (FLYRD18)CVCL_RW47 (HL116)CVCL_3715 (HP)
CVCL_XG90 (HT-1080 JH-1/FIX)CVCL_DF43 (HT-1080 NucLight Green)CVCL_DF44 (HT-1080 NucLight Red)
CVCL_V355 (HT-1080 Tet-Off)CVCL_UZ99 (HT-1080-Luc2)CVCL_VI98 (HT-1080/Arabidopsis hybrid chr15)
CVCL_JG56 (HT-1080/CMV-Luc)CVCL_C3V7 (HT-1080/hCLDN-1)CVCL_C3V8 (HT-1080/hCLDN-2)
CVCL_C3V9 (HT-1080/hCLDN-3)CVCL_C3VA (HT-1080/hCLDN-4)CVCL_C3VB (HT-1080/hCLDN-5)
CVCL_C3VC (HT-1080/hCLDN-6)CVCL_C3VD (HT-1080/hCLDN-7)CVCL_C3VE (HT-1080/hCLDN-9)
CVCL_AR54 (HT-STAR)CVCL_E8JI (HT1080 cyno OX40)CVCL_C0RF (HT1080 EGFP)
CVCL_C0RG (HT1080 EWSR1-FLI1-EGFP)CVCL_AX37 (HT1080 FUS-DDIT3-EGFP)CVCL_XZ54 (HT1080 human CD137)
CVCL_XZ55 (HT1080 human CD27)CVCL_E8JF (HT1080 human CD30)CVCL_XZ56 (HT1080 human CD40)
CVCL_E8JG (HT1080 human FAP)CVCL_UE32 (HT1080 human GITR)CVCL_UE31 (HT1080 human OX40)
CVCL_E8JH (HT1080 mouse CD40)CVCL_RA09 (HT1080-eGFP-Puro)CVCL_RA10 (HT1080-Fluc-Neo/eGFP-Puro)
CVCL_RA11 (HT1080-Fluc-Neo/iRFP-Puro)CVCL_RA12 (HT1080-Fluc-Puro)CVCL_E8F2 (HT1080-HMGB1-Lucia)
CVCL_RA13 (HT1080-hNIS-Neo/eGFP-Puro)CVCL_RA14 (HT1080-hNIS-Neo/Fluc-Puro)CVCL_RA15 (HT1080-hNIS-Neo/iRFP-Puro)
CVCL_RA16 (HT1080-hNIS-Puro)CVCL_RA17 (HT1080-iRFP-Puro)CVCL_L898 (HT1080-luc2)
CVCL_ZJ81 (HT1080-MFAP4 W235F-MH)CVCL_ZJ80 (HT1080-MFAP4 wt-MH)CVCL_5I99 (HT1080-Red-FLuc)
CVCL_C9F8 (HT1080/Cas9 AAVS1)CVCL_6C48 (HT1080/DR4)CVCL_WM79 (HTC75)
CVCL_D683 (HTD114)CVCL_3318 (HX)CVCL_D6BS (HyCyte HT-1080 KO-hSMARCA4)
CVCL_V634 (JH-2/TPA)CVCL_8437 (PEAZ-1)CVCL_D9WD (Ubigene HT-1080 AIFM2 KO)
CVCL_D9WE (Ubigene HT-1080 RIPK1 KO)
Sex of cell Male
Age at sampling 35Y
Category Cancer cell line
STR profile Source(s): ATCC=CCL-121; CCRID; CLS=300216; Cosmic-CLP=907064; DSMZ=ACC-315; ECACC=85111505; JCRB=IFO50354; JCRB=JCRB9113; KCLB=10121; CelloPub=CLPUB00698; PubMed=11416159; PubMed=17254797; PubMed=25877200; RCB=RCB1956; Technion Genomics Center

Markers:
AmelogeninX,Y
CSF1PO11 (PubMed=17254797)
12 (ATCC=CCL-121; CCRID; CLS=300216; Cosmic-CLP=907064; DSMZ=ACC-315; ECACC=85111505; JCRB=IFO50354; JCRB=JCRB9113; KCLB=10121; PubMed=25877200; RCB=RCB1956; Technion Genomics Center)
D1S165616,17.3
D2S44110,14
D2S133825,26
D3S135816
D5S81811,13
D7S8209,10
D8S117913,14
D10S124813,15
D12S39120,22
D13S31712,14
D16S5399,12
D18S5112,18
D19S43313.2,15 (CCRID; Technion Genomics Center)
14,15 (DSMZ=ACC-315)
D21S1128,30
D22S104511,16
DYS39110
FGA22,25
Penta D9,12
Penta E5,15
TH016
TPOX8
vWA14,19

Run an STR similarity search on this cell line
Web pages Info; MCLP; -; https://tcpaportal.org/mclp/
Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/h/cell-lines-detail-124.html
Info; Wikipedia; -; https://en.wikipedia.org/wiki/HT1080
Provider; Altogen; Xenograft model; https://altogenlabs.com/xenograft-models/sarcoma-xenograft/ht1080-xenograft-model/
Publications

PubMed=4132053; DOI=10.1002/1097-0142(197404)33:4<1027::AID-CNCR2820330419>3.0.CO;2-Z
Suraiya Rasheed, Walter Anthony Nelson-Rees, Eva M. Toth, Paul Arnstein, Murray B. Gardner;
Characterization of a newly derived human sarcoma cell line (HT-1080).
Cancer 33:1027-1033(1974)

PubMed=375235; DOI=10.1073/pnas.76.3.1288; PMCID=PMC383236
Stephen A. Sherwin, Ann H. Sliski, George J. Todaro;
Human melanoma cells have both nerve growth factor and nerve growth factor-specific receptors on their cell surfaces.
Proc. Natl. Acad. Sci. U.S.A. 76:1288-1292(1979)

PubMed=22282976; DOI=10.1093/carcin/1.1.21
Rufus S. Day 3rd, Chuck H.J. Ziolkowski, Dominic A. Scudiero, Sharon A. Meyer, Michael R. Mattern;
Human tumor cell strains defective in the repair of alkylation damage.
Carcinogenesis 1:21-32(1980)

PubMed=6652615; DOI=10.1016/0165-4608(83)90092-4
Tchaw-Ren Chen, Robert J. Hay, Marvin L. Macy;
Intercellular karyotypic similarity in near-diploid cell lines of human tumor origins.
Cancer Genet. Cytogenet. 10:351-362(1983)

PubMed=6538202; DOI=10.1083/jcb.98.3.1133; PMCID=PMC2113122
Bruno Azzarone, Horacio Guillermo Suarez, Maria Cristina Mingari, Lorenzo Moretta, Anthony Stephen Fauci;
4F2 monoclonal antibody recognizes a surface antigen on spread human fibroblasts of embryonic but not of adult origin.
J. Cell Biol. 98:1133-1137(1984)

PubMed=3986962; DOI=10.1093/carcin/6.4.549
Masahiro Watatani, Mituo Ikenaga, Toshihiro Hatanaka, Masakatsu Kinuta, Shin-ichiro Takai, Takesada Mori, Sohei Kondo;
Analysis of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced DNA damage in tumor cell strains from Japanese patients and demonstration of MNNG hypersensitivity of Mer xenografts in athymic nude mice.
Carcinogenesis 6:549-553(1985)

PubMed=3558490; DOI=10.1002/jcp.1041300303
Radhey Shyam Gupta, Anil Kumar Dudani;
Species-specific differences in the toxicity of rhodamine 123 towards cultured mammalian cells.
J. Cell. Physiol. 130:321-327(1987)

PubMed=3335022
Michael C. Alley, Dominic A. Scudiero, Anne Monks, Miriam L. Hursey, Maciej J. Czerwinski, Donald L. Fine, Betty Jane Abbott, Joseph G. Mayo, Robert H. Shoemaker, Michael R. Boyd;
Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.
Cancer Res. 48:589-601(1988)

PubMed=3413074; DOI=10.1073/pnas.85.16.6042; PMCID=PMC281901
Olivia M. Pereira-Smith, James R. Smith;
Genetic analysis of indefinite division in human cells: identification of four complementation groups.
Proc. Natl. Acad. Sci. U.S.A. 85:6042-6046(1988)

PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459
John R.W. Masters, Jim A. Thomson, Bernadette Daly-Burns, Yvonne A. Reid, Wilhelm Gerhard Dirks, Phil Packer, Lorraine H. Toji, Tadao Ohno, Hideyuki Tanabe, Colin Francis Arlett, Lloyd R. Kelland ...Show all 16 authors... , Maureen Harrison, Arvind K. Virmani, Timothy H. Ward, Karen L. Ayres, Paul G. Debenham; Show fewer authors
Short tandem repeat profiling provides an international reference standard for human cell lines.
Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001)

PubMed=11668190; DOI=10.1177/002215540104901105
Hilmar Quentmeier, Mary Osborn, Julia Reinhardt, Margarete Zaborski, Hans Gunther Drexler;
Immunocytochemical analysis of cell lines derived from solid tumors.
J. Histochem. Cytochem. 49:1369-1378(2001)

PubMed=12068308; DOI=10.1038/nature00766
Helen R. Davies, Graham Robert Bignell, Charles Cox, Philip J. Stephens, Sarah Edkins, Sheila Clegg, Jon W. Teague, Hayley Woffendin, Mathew J. Garnett, William Bottomley, Neil Davis ...Show all 52 authors... , Ed Dicks, Rebecca Ewing, Yvonne Floyd, Kristian Gray, Sarah Hall, Rachel Hawes, Jaime Hughes, Vivian Kosmidou, Andrew Menzies, Catherine Mould, Adrian Parker, Claire Stevens, Stephen Watt, Steven Hooper, Rebecca Wilson, Hiran Jayatilake, Barry Austin Gusterson, Colin S. Cooper, Janet M. Shipley, Darren Hargrave, Kathy Pritchard-Jones, Norman J. Maitland, Georgia Chenevix-Trench, Gregory J. Riggins, Darell Doty Bigner, Giuseppe Palmieri, Antonio Cossu, Adrienne M. Flanagan, Andrew Nicholson, Judy W.C. Ho, Suet Yi Leung, Siu Tsan Yuen, Barbara L. Weber, Hilliard Foster Seigler, Timothy L. Darrow, Hugh F. Paterson, Richard Marais, Christopher John Marshall, Richard Wooster, Michael Rudolf Stratton, P. Andrew Futreal; Show fewer authors
Mutations of the BRAF gene in human cancer.
Nature 417:949-954(2002)

CLPUB00698
Adrie van Bokhoven;
Models for prostate cancer. Molecular characterization and critical appraisal of human prostate carcinoma cell lines.
Thesis PhD (2004); Katholieke Universiteit Nijmegen; Nijmegen; Netherlands

PubMed=17254797; DOI=10.1016/j.biologicals.2006.10.001
Shahram Azari, Nahid Ahmadi, Mahmood Jeddi-Tehrani, Fazel Shokri;
Profiling and authentication of human cell lines using short tandem repeat (STR) loci: report from the National Cell Bank of Iran.
Biologicals 35:195-202(2007)

PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
Graham Robert Bignell, Christopher D. Greenman, Helen R. Davies, Adam P. Butler, Sarah Edkins, Jenny M. Andrews, Gemma Buck, Lina Chen, David Beare, Calli Latimer, Sara Widaa ...Show all 22 authors... , Jonathan Hinton, Ciara Fahey, Bei-Yuan Fu, Sajani Swamy, Gillian L. Dalgliesh, Bin Tean Teh, Panos Deloukas, Feng-Tang Yang, Peter J. Campbell, P. Andrew Futreal, Michael Rudolf Stratton; Show fewer authors
Signatures of mutation and selection in the cancer genome.
Nature 463:893-898(2010)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=24726063; DOI=10.1186/1756-9966-33-33; PMCID=PMC4022359
Christian Koelsche, Marcus Renner, Wolfgang Hartmann, Regine Brandt, Burkhard Lehner, Nina Waldburger, Ingo Alldinger, Thomas Schmitt, Gerlinde Egerer, Roland Penzel, Eva Wardelmann ...Show all 14 authors... , Peter Schirmacher, Andreas von Deimling, Gunhild Mechtersheimer; Show fewer authors
TERT promoter hotspot mutations are recurrent in myxoid liposarcomas but rare in other soft tissue sarcoma entities.
J. Exp. Clin. Cancer Res. 33:33.1-33.8(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26351324; DOI=10.1158/1535-7163.MCT-15-0074; PMCID=PMC4636476
Beverly A. Teicher, Eric C. Polley, Mark W. Kunkel, David Evans, Thomas E. Silvers, Rene M. Delosh, Julie Laudeman, Chad Ogle, Russell Reinhart, Michael Selby, John Connelly ...Show all 14 authors... , Erik Harris, Anne Monks, Joel Morris; Show fewer authors
Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.
Mol. Cancer Ther. 14:2452-2462(2015)

PubMed=26368816; DOI=10.1371/journal.pone.0133813; PMCID=PMC4569544
Lu-Yuan Li, Ana C. Paz, Breelyn A. Wilky, Britt Johnson, Karina Galoian, Andrew Rosenberg, Guo-Zhi Hu, Gabriel Tinoco, Olaf A. Bodamer, Jonathan C. Trent 2nd;
Treatment with a small molecule mutant IDH1 inhibitor suppresses tumorigenic activity and decreases production of the oncometabolite 2-hydroxyglutarate in human chondrosarcoma cells.
PLoS ONE 10:e0133813.1-e0133813.19(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254
David Paul Nusinow, John Szpyt, Mahmoud Ghandi, Christopher M. Rose, E. Robert McDonald 3rd, Marian Kalocsay, Judit Jane-Valbuena, Ellen T. Gelfand, Devin K. Schweppe, Mark P. Jedrychowski, Javad Golji ...Show all 20 authors... , Dale A. Porter, Tomas Rejtar, Y. Karen Wang, Gregory V. Kryukov, Frank Stegmeier, Brian K. Erickson, Levi Alexander Garraway, William Raj Sellers, Steven P. Gygi; Show fewer authors
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Emanuel Goncalves, Rebecca C. Poulos, Zhao-Xiang Cai, Syd Barthorpe, Srikanth S. Manda, Natasha Lucas, Alexandra Beck, Daniel Bucio-Noble, Michael Dausmann, Caitlin Hall, Michael Hecker ...Show all 32 authors... , Jennifer Koh, Howard Lightfoot, Sadia Mahboob, Iman Mali, James Morris, Laura Richardson, Akila J. Seneviratne, Rebecca Shepherd, Erin Sykes, Frances Thomas, Sara Valentini, Steven G. Williams, Yang-Xiu Wu, Dylan Xavier, Karen L. MacKenzie, Peter G. Hains, Brett Tully, Phillip James Robinson, Qing Zhong, Mathew J. Garnett, Roger Robert Reddel; Show fewer authors
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) ABM; T8971
ATCC; CCL-121
ATCC; CRL-7951 - Discontinued
BCRC; 60037
BCRJ; 0110
CCTCC; GDC0105
CLS; 300216
DSMZ; ACC-315
ECACC; 85111505
IBRC; C10104
ICLC; HTL98016
IZSLER; BS TCL 27
JCRB; IFO50354
JCRB; JCRB9113
KCB; KCB 2013029YJ
KCLB; 10121
NCBI_Iran; C437
RCB; RCB1956 - Discontinued
TKG; TKG 0202
Cell line databases/resources CLO; CLO_0004266
CLO; CLO_0004276
MCCL; MCC:0000210
CLDB; cl1735
CLDB; cl1736
CLDB; cl1737
CLDB; cl1738
CLDB; cl1740
CLDB; cl1741
CLDB; cl1742
CLDB; cl4913
cancercelllines; CVCL_0317
CCRID; 1101HUM-PUMC000070
CCRID; 3101HUMTCHu170
CCRID; 4201HUM-CCTCC00105
Cell_Model_Passport; SIDM00828
Cosmic-CLP; 907064
DepMap; ACH-000054
DSMZCellDive; ACC-315
IGRhCellID; HT1080
LINCS_LDP; LCL-1435
Lonza; 744
TOKU-E; 1963
Anatomy/cell type resources BTO; BTO_0001282
Biological sample resources BioSample; SAMN01821563
BioSample; SAMN01821634
BioSample; SAMN01821685
BioSample; SAMN01821731
BioSample; SAMN03471913
BioSample; SAMN10987635
ENCODE; ENCBS039VHD
ENCODE; ENCBS225AAA
ENCODE; ENCBS512AAA
ENCODE; ENCBS513AAA
ENCODE; ENCBS617SGR
ENCODE; ENCBS688VJF
ENCODE; ENCBS798NML
ENCODE; ENCBS816VMN
ENCODE; ENCBS937RAY
CRISP screens repositories BioGRID_ORCS_Cell_line; 279
Chemistry resources ChEMBL-Cells; CHEMBL3308396
ChEMBL-Targets; CHEMBL614580
GDSC; 907064
PharmacoDB; HT1080_625_2019
PubChem_Cell_line; CVCL_0317
Encyclopedic resources Wikidata; Q5636047
Experimental variables resources EFO; EFO_0002059
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
FANTOM5_SSTAR; 10758-110E2
GEO; GSM185089
GEO; GSM185090
GEO; GSM256074
GEO; GSM256075
GEO; GSM256076
GEO; GSM256077
GEO; GSM256078
GEO; GSM256079
GEO; GSM256080
GEO; GSM256081
GEO; GSM256082
GEO; GSM256083
GEO; GSM256084
GEO; GSM256085
GEO; GSM256086
GEO; GSM256087
GEO; GSM256088
GEO; GSM256089
GEO; GSM256090
GEO; GSM256091
GEO; GSM256092
GEO; GSM256093
GEO; GSM256094
GEO; GSM256095
GEO; GSM256096
GEO; GSM256097
GEO; GSM256098
GEO; GSM256099
GEO; GSM256100
GEO; GSM256101
GEO; GSM256102
GEO; GSM256103
GEO; GSM256104
GEO; GSM256105
GEO; GSM256106
GEO; GSM256107
GEO; GSM256108
GEO; GSM256109
GEO; GSM256110
GEO; GSM256111
GEO; GSM256112
GEO; GSM256113
GEO; GSM256114
GEO; GSM827307
GEO; GSM887136
GEO; GSM888207
GEO; GSM1669908
GEO; GSM1676302
GEO; GSM1701637
GEO; GSM3585511
GEO; GSM3585512
GEO; GSM3585513
GEO; GSM3585514
Polymorphism and mutation databases Cosmic; 716177
Cosmic; 716188
Cosmic; 724819
Cosmic; 907064
Cosmic; 912000
Cosmic; 1045409
Cosmic; 1067221
Cosmic; 1933190
Cosmic; 2009505
Cosmic; 2301553
Cosmic; 2307731
Cosmic; 2560245
Cosmic; 2764533
IARC_TP53; 21378
LiGeA; CCLE_463
Progenetix; CVCL_0317
Proteomic databases PRIDE; PXD030304
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Apr-2025
Version number50