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Cellosaurus HT1080 EWSR1-FLI1-EGFP (CVCL_C0RG)

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Cell line name HT1080 EWSR1-FLI1-EGFP
Synonyms HT1080_EWSR1-FLI1-EGFP
Accession CVCL_C0RG
Resource Identification Initiative To cite this cell line use: HT1080 EWSR1-FLI1-EGFP (RRID:CVCL_C0RG)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:3508; EWSR1 (Note=EWSR1-FLI1 fusion).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:3749; FLI1 (Note=EWSR1-FLI1 fusion).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Bone, pelvis, acetabulum; UBERON=UBERON_0001269.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:5382; IDH1; Simple; p.Arg132Cys (c.394C>T); ClinVar=VCV000375891; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
Disease Fibrosarcoma (NCIt: C3043)
Fibrosarcoma (ORDO: Orphanet_2030)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0317 (HT-1080)
Sex of cell Male
Age at sampling 35Y
Category Cancer cell line
Publications

PubMed=30962207; DOI=10.15252/embr.201845766; PMCID=PMC6500973
Malin Linden, Christer Thomsen, Pernilla Grundevik, Emma Jonasson, Daniel Andersson, Rikard Runnberg, Soheila Dolatabadi, Christoffer Vannas, Manuel Luna Santamaria, Henrik Fagman, Anders Stahlberg, Pierre Aman;
FET family fusion oncoproteins target the SWI/SNF chromatin remodeling complex.
EMBO Rep. 20:e45766.1-e45766.15(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C0RG
Encyclopedic resources Wikidata; Q112929756
Gene expression databases GEO; GSM3585522
GEO; GSM3585523
GEO; GSM3585524
GEO; GSM3585525
Entry history
Entry creation23-Jun-2022
Last entry update14-Aug-2025
Version number10