Cellosaurus logo
expasy logo

Cellosaurus HT1080-HMGB1-Lucia (CVCL_E8F2)

[Text][XML][JSON]
Cell line name HT1080-HMGB1-Lucia
Accession CVCL_E8F2
Resource Identification Initiative To cite this cell line use: HT1080-HMGB1-Lucia (RRID:CVCL_E8F2)
Comments Population: Caucasian.
Characteristics: Designed to monitor ferroptosis, a form of non-apoptotic cell death. Stably express an HMGB1::Lucia luciferase fusion protein in the cytoplasm, following ferroptosis activation, the cell membrane ruptures and HMGB1::Lucia is released in the extracellular milieu (InvivoGen=ht80-gb1lc).
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:4983; HMGB1.
Genetic integration: Method=Transfection; Gene=UniProtKB; P33967; Bacillus cereus Bsr.
Genetic integration: Method=Transfection; Gene=Synthetic construct Lucia luciferase (Note=Synthetic gene designed on natural secreted luciferase genes from marine copepods).
Derived from site: In situ; Bone, pelvis, acetabulum; UBERON=UBERON_0001269.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:5382; IDH1; Simple; p.Arg132Cys (c.394C>T); ClinVar=VCV000375891; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
Disease Fibrosarcoma (NCIt: C3043)
Fibrosarcoma (ORDO: Orphanet_2030)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0317 (HT-1080)
Sex of cell Male
Age at sampling 35Y
Category Cancer cell line
Cross-references
Cell line collections (Providers) InvivoGen; ht80-gb1lc
Entry history
Entry creation10-Apr-2025
Last entry update14-Aug-2025
Version number2