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Cellosaurus HL116 (CVCL_RW47)

[Text version]
Cell line name HL116
Accession CVCL_RW47
Resource Identification Initiative To cite this cell line use: HL116 (RRID:CVCL_RW47)
Comments Population: Caucasian.
Characteristics: The luciferase reporter gene is under the control of a IFN-alpha inducible IFI6 (6-16) promoter.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P0A9M5; Escherichia coli gpt.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase.
Derived from site: In situ; Bone, pelvis, acetabulum; UBERON=UBERON_0001269.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:5382; IDH1; Simple; p.Arg132Cys (c.394C>T); ClinVar=VCV000375891; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
Disease Fibrosarcoma (NCIt: C3043)
Fibrosarcoma (ORDO: Orphanet_2030)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0317 (HT-1080)
Sex of cell Male
Age at sampling 35Y
Category Cancer cell line
Publications

PubMed=7932753; DOI=10.1006/jmbi.1994.1651
Gilles Uze, Stefania Di Marco, Emmanuele Mouchel-Vielh, Daniele Monneron, Marie-Therese Bandu, Michel A. Horisberger, Alice Dorques, Georges Lutfalla, Knud Erik Mogensen;
Domains of interaction between alpha interferon and its receptor components.
J. Mol. Biol. 243:245-257(1994)

Cross-references
Cell line databases/resources cancercelllines; CVCL_RW47
Encyclopedic resources Wikidata; Q54889817
Entry history
Entry creation05-Mar-2018
Last entry update14-Aug-2025
Version number16