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Cellosaurus HT-1080/hCLDN-9 (CVCL_C3VE)

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Cell line name HT-1080/hCLDN-9
Synonyms hCLDN-9/HT1080
Accession CVCL_C3VE
Resource Identification Initiative To cite this cell line use: HT-1080/hCLDN-9 (RRID:CVCL_C3VE)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:2051; CLDN9.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Bone, pelvis, acetabulum; UBERON=UBERON_0001269.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:5382; IDH1; Simple; p.Arg132Cys (c.394C>T); ClinVar=VCV000375891; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
Disease Fibrosarcoma (NCIt: C3043)
Fibrosarcoma (ORDO: Orphanet_2030)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0317 (HT-1080)
Sex of cell Male
Age at sampling 35Y
Category Cancer cell line
Publications

PubMed=27713828; DOI=10.1002/prp2.266; PMCID=PMC5045943
Yosuke Hashimoto, Yumi Kawahigashi, Tomoyuki Hata, Xiang-Ru Li, Akihiro Watari, Minoru Tada, Akiko Ishii-Watabe, Yoshiaki Okada, Takefumi Doi, Masayoshi Fukasawa, Hiroki Kuniyasu ...Show all 13 authors... , Kiyohito Yagi, Masuo Kondoh; Show fewer authors
Efficacy and safety evaluation of claudin-4-targeted antitumor therapy using a human and mouse cross-reactive monoclonal antibody.
Pharmacol. Res. Perspect. 4:e00266.1-e00266.14(2016)

Cross-references
Encyclopedic resources Wikidata; Q116049513
Entry history
Entry creation15-Dec-2022
Last entry update14-Aug-2025
Version number6