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Cellosaurus HT1080 FUS-DDIT3-EGFP (CVCL_AX37)

[Text version]
Cell line name HT1080 FUS-DDIT3-EGFP
Synonyms HT1080_FUS-DDIT3-EGFP
Accession CVCL_AX37
Resource Identification Initiative To cite this cell line use: HT1080 FUS-DDIT3-EGFP (RRID:CVCL_AX37)
Comments Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:2726; DDIT3 (Note=FUS-DDIT3 fusion).
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:4010; FUS (Note=FUS-DDIT3 fusion).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Bone, pelvis, acetabulum; UBERON=UBERON_0001269.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:5382; IDH1; Simple; p.Arg132Cys (c.394C>T); ClinVar=VCV000375891; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
Disease Fibrosarcoma (NCIt: C3043)
Fibrosarcoma (ORDO: Orphanet_2030)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0317 (HT-1080)
Sex of cell Male
Age at sampling 35Y
Category Cancer cell line
Publications

PubMed=16651630; DOI=10.2353/ajpath.2006.050872; PMCID=PMC1606602
Katarina Engstrom, Helena Willen, Christina Kabjorn-Gustafsson, Carola Andersson, Marita Olsson, Melker Goransson, Sofia Thelin-Jarnum, Anita Olofsson, Elisabeth Warnhammar, Pierre Aman;
The myxoid/round cell liposarcoma fusion oncogene FUS-DDIT3 and the normal DDIT3 induce a liposarcoma phenotype in transfected human fibrosarcoma cells.
Am. J. Pathol. 168:1642-1653(2006)

PubMed=25393000; DOI=10.1371/journal.pone.0113110; PMCID=PMC4231113
Anders Stahlberg, Christina Kabjorn-Gustafsson, Katarina Engtrom, Christer Thomsen, Soheila Dolatabadi, Emma Jonasson, Chieh-Yuan Li, David Ruff, Shiaw-Min Chen, Pierre Aman;
Normal and functional TP53 in genetically stable myxoid/round cell liposarcoma.
PLoS ONE 9:e113110.1-e113110.7(2014)

PubMed=30962207; DOI=10.15252/embr.201845766; PMCID=PMC6500973
Malin Linden, Christer Thomsen, Pernilla Grundevik, Emma Jonasson, Daniel Andersson, Rikard Runnberg, Soheila Dolatabadi, Christoffer Vannas, Manuel Luna Santamaria, Henrik Fagman, Anders Stahlberg, Pierre Aman;
FET family fusion oncoproteins target the SWI/SNF chromatin remodeling complex.
EMBO Rep. 20:e45766.1-e45766.15(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_AX37
Encyclopedic resources Wikidata; Q54896556
Gene expression databases GEO; GSM3585519
GEO; GSM3585520
GEO; GSM3585521
Entry history
Entry creation02-May-2016
Last entry update14-Aug-2025
Version number21