ID   HT1080 FUS-DDIT3-EGFP
AC   CVCL_AX37
SY   HT1080_FUS-DDIT3-EGFP
DR   cancercelllines; CVCL_AX37
DR   GEO; GSM3585519
DR   GEO; GSM3585520
DR   GEO; GSM3585521
DR   Wikidata; Q54896556
RX   PubMed=16651630;
RX   PubMed=25393000;
RX   PubMed=30962207;
CC   Population: Caucasian.
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 5382; IDH1; Simple; p.Arg132Cys (c.394C>T); ClinVar=VCV000375891; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
CC   Transfected with: HGNC; 2726; DDIT3 (FUS-DDIT3 fusion).
CC   Transfected with: HGNC; 4010; FUS (FUS-DDIT3 fusion).
CC   Transfected with: UniProtKB; P42212; GFP (with p.Phe64Leu, p.Ser65Thr and p.His231Leu = EGFP).
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Bone, pelvis, acetabulum; UBERON=UBERON_0001269.
DI   NCIt; C3043; Fibrosarcoma
DI   ORDO; Orphanet_2030; Fibrosarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0317 ! HT-1080
SX   Male
AG   35Y
CA   Cancer cell line
DT   Created: 02-05-16; Last updated: 05-10-23; Version: 17
//
RX   PubMed=16651630; DOI=10.2353/ajpath.2006.050872;
RA   Engstrom K., Willen H., Kabjorn-Gustafsson C., Andersson C.,
RA   Olsson M., Goransson M., Thelin-Jarnum S., Olofsson A., Warnhammar E.,
RA   Aman P.;
RT   "The myxoid/round cell liposarcoma fusion oncogene FUS-DDIT3 and the
RT   normal DDIT3 induce a liposarcoma phenotype in transfected human
RT   fibrosarcoma cells.";
RL   Am. J. Pathol. 168:1642-1653(2006).
//
RX   PubMed=25393000; DOI=10.1371/journal.pone.0113110;
RA   Stahlberg A., Kabjorn-Gustafsson C., Engtrom K., Thomsen C.,
RA   Dolatabadi S., Jonasson E., Li C.-Y., Ruff D., Chen S.-M., Aman P.;
RT   "Normal and functional TP53 in genetically stable myxoid/round cell
RT   liposarcoma.";
RL   PLoS ONE 9:E113110-E113110(2014).
//
RX   PubMed=30962207; DOI=10.15252/embr.201845766;
RA   Linden M., Thomsen C., Grundevik P., Jonasson E., Andersson D.,
RA   Runnberg R., Dolatabadi S., Vannas C., Santamaria M.L.,
RA   Fagman H., Stahlberg A., Aman P.;
RT   "FET family fusion oncoproteins target the SWI/SNF chromatin
RT   remodeling complex.";
RL   EMBO Rep. 20:e45766.1-e45766.15(2019).
//