ID   HT1080 FUS-DDIT3-EGFP
AC   CVCL_AX37
SY   HT1080_FUS-DDIT3-EGFP
DR   cancercelllines; CVCL_AX37
DR   GEO; GSM3585519
DR   GEO; GSM3585520
DR   GEO; GSM3585521
DR   Wikidata; Q54896556
RX   PubMed=16651630;
RX   PubMed=25393000;
RX   PubMed=30962207;
CC   Population: Caucasian.
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:5382; IDH1; Simple; p.Arg132Cys (c.394C>T); ClinVar=VCV000375891; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:2726; DDIT3 (Note=FUS-DDIT3 fusion).
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:4010; FUS (Note=FUS-DDIT3 fusion).
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
CC   Omics: Transcriptomics; RNAseq.
CC   Derived from site: In situ; Bone, pelvis, acetabulum; UBERON=UBERON_0001269.
DI   NCIt; C3043; Fibrosarcoma
DI   ORDO; Orphanet_2030; Fibrosarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0317 ! HT-1080
SX   Male
AG   35Y
CA   Cancer cell line
DT   Created: 02-05-16; Last updated: 14-08-25; Version: 21
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RX   PubMed=30962207; DOI=10.15252/embr.201845766; PMCID=PMC6500973;
RA   Linden, Malin
RA   Thomsen, Christer
RA   Grundevik, Pernilla
RA   Jonasson, Emma
RA   Andersson, Daniel
RA   Runnberg, Rikard
RA   Dolatabadi, Soheila
RA   Vannas, Christoffer
RA   Santamaria, Manuel Luna
RA   Fagman, Henrik
RA   Stahlberg, Anders
RA   Aman, Pierre
RT   "FET family fusion oncoproteins target the SWI/SNF chromatin
RT   remodeling complex.";
RL   EMBO Rep. 20:e45766.1-e45766.15(2019).
//
RX   PubMed=16651630; DOI=10.2353/ajpath.2006.050872; PMCID=PMC1606602;
RA   Engstrom, Katarina
RA   Willen, Helena
RA   Kabjorn-Gustafsson, Christina
RA   Andersson, Carola
RA   Olsson, Marita
RA   Goransson, Melker
RA   Thelin-Jarnum, Sofia
RA   Olofsson, Anita
RA   Warnhammar, Elisabeth
RA   Aman, Pierre
RT   "The myxoid/round cell liposarcoma fusion oncogene FUS-DDIT3 and the
RT   normal DDIT3 induce a liposarcoma phenotype in transfected human
RT   fibrosarcoma cells.";
RL   Am. J. Pathol. 168:1642-1653(2006).
//
RX   PubMed=25393000; DOI=10.1371/journal.pone.0113110; PMCID=PMC4231113;
RA   Stahlberg, Anders
RA   Kabjorn-Gustafsson, Christina
RA   Engtrom, Katarina
RA   Thomsen, Christer
RA   Dolatabadi, Soheila
RA   Jonasson, Emma
RA   Li, Chieh-Yuan
RA   Ruff, David
RA   Chen, Shiaw-Min
RA   Aman, Pierre
RT   "Normal and functional TP53 in genetically stable myxoid/round cell
RT   liposarcoma.";
RL   PLoS ONE 9:e113110.1-e113110.7(2014).
//