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Cellosaurus HT-1080 Tet-Off (CVCL_V355)

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Cell line name HT-1080 Tet-Off
Synonyms Tet-off HT-1080
Accession CVCL_V355
Resource Identification Initiative To cite this cell line use: HT-1080 Tet-Off (RRID:CVCL_V355)
Comments Population: Caucasian.
Characteristics: Transfected with the tetracycline transactivator (tTA) protein, a fusion of tetR with the activation domain of HSV-1 VP16.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P04483; Escherichia coli Tn10 tetR.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P06492; Human herpesvirus 1 (HHV-1) VP16 (UL28) (Note=With p.Met1_Arg360del).
Derived from site: In situ; Bone, pelvis, acetabulum; UBERON=UBERON_0001269.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:5382; IDH1; Simple; p.Arg132Cys (c.394C>T); ClinVar=VCV000375891; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
Disease Fibrosarcoma (NCIt: C3043)
Fibrosarcoma (ORDO: Orphanet_2030)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0317 (HT-1080)
Sex of cell Male
Age at sampling 35Y
Category Cancer cell line
Web pages Provider; Takara Bio; 630916; https://www.takarabio.com/documents/Certificate%20of%20Analysis/630916/630916-PA033658.pdf
Cross-references
Cell line databases/resources cancercelllines; CVCL_V355
TOKU-E; 3749
Encyclopedic resources Wikidata; Q54896500
Entry history
Entry creation16-Apr-2014
Last entry update14-Aug-2025
Version number23