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Cellosaurus THP-1 (CVCL_0006)

[Text version]

Cell line name THP-1
Synonyms THP1; THP 1; THPI; THP-1(ATCC); THP-1-O; O-THP-1; Tohoku Hospital Pediatrics-1
Accession CVCL_0006
Resource Identification Initiative To cite this cell line use: THP-1 (RRID:CVCL_0006)
Comments Group: Space-flown cell line (cellonaut).
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: LL-100 blood cancer cell line panel.
Part of: MD Anderson Cell Lines Project.
Part of: RAS genetic alteration cell panel (ATCC TCP-1031).
Part of: Tumor Immunology Bank (TIB) collection from Salk (transferred to ATCC in 1981).
Population: Japanese.
Biotechnology: Used in the human Cell Line Activation Test (h-CLAT), an in vitro skin sensitization test (PubMed=16311011; PubMed=16337770; PubMed=29901211).
Characteristics: Can differentiate from monocytes into macrophage-like cells upon stimulation with PMA.
Characteristics: Not susceptible to SARS coronavirus 2 (SARS-CoV-2) infection (COVID-19) (PubMed=33389257).
Doubling time: 60-70 hours (PubMed=6970727); 26 hours (PubMed=25984343); ~35-50 hours (DSMZ).
Microsatellite instability: Stable (MSS) (PubMed=10739008; PubMed=11226526; Sanger).
Omics: Deep antibody staining analysis.
Omics: Deep exome analysis.
Omics: Deep promoter analysis.
Omics: Deep quantitative proteome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: Glycoproteome analysis by proteomics.
Omics: HLA class I peptidome analysis by proteomics.
Omics: Protein expression by reverse-phase protein arrays.
Omics: shRNA library screening.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Anecdotal: Have been flown in space on Cosmos-2044 to study the inhibition of phorbol ester-induced cell activation in microgravity (PubMed=352912).
Caution: NRAS mutation indicated incorrectly as being p.Gly12Ser in PubMed=9379676.
Derived from sampling site: Peripheral blood.
Sequence variations
  • Gene fusion; HGNC; 2457; CSNK2A1 + HGNC; 13917; DDX39B; Name(s)=CSNK2A1-DDX39B (PubMed=31160637).
  • Gene fusion; HGNC; 7132; KMT2A + HGNC; 7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (PubMed=11066077; PubMed=15843827).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (PubMed=12068308; ATCC; Cosmic-CLP; DepMap).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg174fs*3 (c.520_545del26); Zygosity=Heterozygous (PubMed=1571549; PubMed=19220422; DepMap).
HLA typing Source: PubMed=22674354
Class I
HLA-AA*02
HLA-BB*15:11
HLA-CC*03
Class II
HLA-DQDQB1*05,06
HLA-DRDRB1*01,15
DRB5*01/02

Source: CLS
Class I
HLA-AA*02:01:01
HLA-BB*15:11:01
HLA-CC*03:03:01
Class II
HLA-DPDPB1*02:01:02G,04:02:01G
HLA-DQDQA1*01:01:01,01:02:01
DQB1*05:01:01,06:02:01
HLA-DRDRB1*01:01:01,15:01:01

Source: DSMZ
Class I
HLA-AA*02:01:01,24:02:01
HLA-BB*15:11:01,35:01:01
HLA-CC*03:03:01,03:03:01
Class II
HLA-DPDPA1*01:03:01,02:02:02
DPB1*02:01:02,04:02:01
HLA-DQDQB1*05:01:01,06:02:01
HLA-DRDRA*01:01:01,01:01:01
DRB1*01:01:01,15:01:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.3
East Asian, North77.63
East Asian, South20.4
South Asian1.67
European, North0
European, South0
Disease Childhood acute monocytic leukemia (NCIt: C9163)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_5115 (A-THP-1 )CVCL_B9W7 (Abcam THP-1 AATF KO )CVCL_B9W8 (Abcam THP-1 ABCB1 KO )
CVCL_B9W9 (Abcam THP-1 ABL1 KO )CVCL_B9WA (Abcam THP-1 ACVR1B KO )CVCL_B9WB (Abcam THP-1 ADGRG1 KO )
CVCL_B9WC (Abcam THP-1 AGTR1 KO )CVCL_B9WD (Abcam THP-1 AHR KO )CVCL_B9WE (Abcam THP-1 AIM2 KO )
CVCL_B9WF (Abcam THP-1 ALCAM KO )CVCL_B9WG (Abcam THP-1 ALKBH1 KO )CVCL_B9WH (Abcam THP-1 ALYREF KO )
CVCL_B1A1 (Abcam THP-1 ANPEP KO )CVCL_B9WI (Abcam THP-1 APOBEC3B KO )CVCL_B9WJ (Abcam THP-1 ASAH1 KO )
CVCL_B9WK (Abcam THP-1 ATF5 KO )CVCL_B1A2 (Abcam THP-1 ATG12 KO )CVCL_B1A3 (Abcam THP-1 ATG14 KO )
CVCL_B1A4 (Abcam THP-1 ATG16L1 KO )CVCL_B9WL (Abcam THP-1 ATG3 KO )CVCL_B1A5 (Abcam THP-1 ATG5 KO )
CVCL_B1A6 (Abcam THP-1 ATG7 KO )CVCL_B9WM (Abcam THP-1 ATG9A KO )CVCL_B9WN (Abcam THP-1 BAK1 KO )
CVCL_B1A7 (Abcam THP-1 BCL2 KO )CVCL_B9WP (Abcam THP-1 BMPR2 KO )CVCL_B9WQ (Abcam THP-1 BRD1 KO )
CVCL_B9WR (Abcam THP-1 BRD2 KO )CVCL_B9WS (Abcam THP-1 BRD9 KO )CVCL_B9WT (Abcam THP-1 BTG1 KO )
CVCL_B9WU (Abcam THP-1 BTK KO )CVCL_B9WV (Abcam THP-1 BTRC KO )CVCL_B9WW (Abcam THP-1 C3 KO )
CVCL_B1A8 (Abcam THP-1 CASP1 KO )CVCL_B9WX (Abcam THP-1 CASP3 KO )CVCL_B1A9 (Abcam THP-1 CASP9 KO )
CVCL_B1AA (Abcam THP-1 CCL3 KO )CVCL_B9WY (Abcam THP-1 CCL4 KO )CVCL_B9WZ (Abcam THP-1 CCR2 KO )
CVCL_B9X0 (Abcam THP-1 CCRL2 KO )CVCL_B9X1 (Abcam THP-1 CCL22 KO )CVCL_B9X2 (Abcam THP-1 CD36 KO )
CVCL_B9X3 (Abcam THP-1 CD48 KO )CVCL_B9X4 (Abcam THP-1 CD58 KO )CVCL_B9X5 (Abcam THP-1 CD59 KO )
CVCL_B9X6 (Abcam THP-1 CD81 KO )CVCL_B1AB (Abcam THP-1 CHI3L1 KO )CVCL_B9X7 (Abcam THP-1 CITED2 KO )
CVCL_B9X8 (Abcam THP-1 CLU KO )CVCL_B9X9 (Abcam THP-1 CMKLR1 KO )CVCL_B9XA (Abcam THP-1 CMTM6 KO )
CVCL_B9XB (Abcam THP-1 CNR2 KO )CVCL_B9XC (Abcam THP-1 CST3 KO )CVCL_B9XD (Abcam THP-1 CTSB KO )
CVCL_B9XE (Abcam THP-1 CTSS KO )CVCL_B9XF (Abcam THP-1 CUL2 KO )CVCL_B9XG (Abcam THP-1 CUL3 KO )
CVCL_B9XH (Abcam THP-1 CUL4B KO )CVCL_B9XI (Abcam THP-1 CX3CR1 KO )CVCL_B1AC (Abcam THP-1 CXCL10 KO )
CVCL_B1AD (Abcam THP-1 CXCR2 KO )CVCL_B9XJ (Abcam THP-1 CXXC1 KO )CVCL_B9XK (Abcam THP-1 DCP2 KO )
CVCL_B9XL (Abcam THP-1 DLL1 KO )CVCL_B9XM (Abcam THP-1 DVL3 KO )CVCL_B9XN (Abcam THP-1 EGLN1 KO )
CVCL_B9XP (Abcam THP-1 EHMT2 KO )CVCL_B9XQ (Abcam THP-1 EIF2AK4 KO )CVCL_B9XR (Abcam THP-1 ENG KO )
CVCL_B9XS (Abcam THP-1 EPHB4 KO )CVCL_B9XT (Abcam THP-1 ERAP1 KO )CVCL_B9XU (Abcam THP-1 ETS2 KO )
CVCL_B9XV (Abcam THP-1 EXO1 KO )CVCL_B9XW (Abcam THP-1 FABP4 KO )CVCL_B9XX (Abcam THP-1 FCGR1A KO )
CVCL_B9XY (Abcam THP-1 FGF23 KO )CVCL_B9XZ (Abcam THP-1 FKBP5 KO )CVCL_B9Y0 (Abcam THP-1 FOXO1 KO )
CVCL_B9Y1 (Abcam THP-1 FOXO3 KO )CVCL_B9Y2 (Abcam THP-1 FST KO )CVCL_B9Y3 (Abcam THP-1 FTL KO )
CVCL_B9Y4 (Abcam THP-1 FZD7 KO )CVCL_B9Y5 (Abcam THP-1 GAB1 KO )CVCL_B9Y6 (Abcam THP-1 GLB1 KO )
CVCL_B9Y7 (Abcam THP-1 GPR132 KO )CVCL_B9Y8 (Abcam THP-1 GZMA KO )CVCL_B9Y9 (Abcam THP-1 HLA-B KO )
CVCL_B9YA (Abcam THP-1 HNF1B KO )CVCL_B9YB (Abcam THP-1 HSPG2 KO )CVCL_B9YC (Abcam THP-1 ID2 KO )
CVCL_B9YD (Abcam THP-1 IL17RB KO )CVCL_B1AE (Abcam THP-1 IL1B KO )CVCL_B9YE (Abcam THP-1 IRAK3 KO )
CVCL_B9YF (Abcam THP-1 ITPR3 KO )CVCL_B9YG (Abcam THP-1 JAG1 KO )CVCL_B9YH (Abcam THP-1 JMJD6 KO )
CVCL_B9YI (Abcam THP-1 KAT7 KO )CVCL_B9YJ (Abcam THP-1 KDM1B KO )CVCL_B9YK (Abcam THP-1 KDM6B KO )
CVCL_B9YL (Abcam THP-1 KPNA2 KO )CVCL_B9YM (Abcam THP-1 LAIR1 KO )CVCL_B9YN (Abcam THP-1 LAMP2 KO )
CVCL_B1AF (Abcam THP-1 LATS1 KO )CVCL_B9YP (Abcam THP-1 LDHA KO )CVCL_B1AG (Abcam THP-1 LGALS9 KO )
CVCL_B9YQ (Abcam THP-1 LGR6 KO )CVCL_B9YR (Abcam THP-1 LMNB1 KO )CVCL_B1AH (Abcam THP-1 LYZ KO )
CVCL_B9YS (Abcam THP-1 MACROH2A1 KO )CVCL_B9YT (Abcam THP-1 MAGEA3 KO )CVCL_B9YU (Abcam THP-1 MAP2K3 KO )
CVCL_B9YV (Abcam THP-1 MAP3K3 KO )CVCL_B9YW (Abcam THP-1 MAPK7 KO )CVCL_B9YX (Abcam THP-1 MBD1 KO )
CVCL_B9YY (Abcam THP-1 MBD3 KO )CVCL_B9YZ (Abcam THP-1 MME KO )CVCL_B9Z0 (Abcam THP-1 MMP13 KO )
CVCL_B9Z1 (Abcam THP-1 MMP8 KO )CVCL_B9Z2 (Abcam THP-1 MTA3 KO )CVCL_B9Z3 (Abcam THP-1 NBR1 KO )
CVCL_B9Z4 (Abcam THP-1 NCR3LG1 KO )CVCL_B9Z5 (Abcam THP-1 NFKB1 KO )CVCL_B9Z6 (Abcam THP-1 NLRC4 KO )
CVCL_B9Z7 (Abcam THP-1 NLRP3 KO )CVCL_B9Z8 (Abcam THP-1 NOTCH3 KO )CVCL_B9Z9 (Abcam THP-1 NOTCH4 KO )
CVCL_B9ZA (Abcam THP-1 NQO1 KO )CVCL_B9ZB (Abcam THP-1 NR1H4 KO )CVCL_B9ZC (Abcam THP-1 NR3C2 KO )
CVCL_B9ZD (Abcam THP-1 PDCD1LG2 KO )CVCL_B9ZE (Abcam THP-1 PHF8 KO )CVCL_B9ZF (Abcam THP-1 PIK3CA KO )
CVCL_B9ZG (Abcam THP-1 PIK3CD KO )CVCL_B9ZH (Abcam THP-1 PIK3R4 KO )CVCL_B9ZI (Abcam THP-1 PLA2G4A KO )
CVCL_B9ZJ (Abcam THP-1 PLAU KO )CVCL_B9ZK (Abcam THP-1 PLCB3 KO )CVCL_B9ZL (Abcam THP-1 PLCG1 KO )
CVCL_B9ZM (Abcam THP-1 PRMT7 KO )CVCL_B9ZN (Abcam THP-1 PSEN1 KO )CVCL_B9ZP (Abcam THP-1 PTGER4 KO )
CVCL_B9ZQ (Abcam THP-1 PTGES2 KO )CVCL_B9ZR (Abcam THP-1 PTK2 KO )CVCL_B9ZS (Abcam THP-1 PTP4A3 KO )
CVCL_B9ZT (Abcam THP-1 PTPN12 KO )CVCL_B1AI (Abcam THP-1 PTPN6 KO )CVCL_B9ZU (Abcam THP-1 PUS1 KO )
CVCL_B9ZV (Abcam THP-1 RAC2 KO )CVCL_B9ZW (Abcam THP-1 RING1 KO )CVCL_B1AJ (Abcam THP-1 RIPK1 KO )
CVCL_B9ZX (Abcam THP-1 ROCK2 KO )CVCL_B9ZY (Abcam THP-1 ROR2 KO )CVCL_B9ZZ (Abcam THP-1 RUNX2 KO )
CVCL_C0A0 (Abcam THP-1 RYBP KO )CVCL_C0A1 (Abcam THP-1 S100A8 KO )CVCL_C0A2 (Abcam THP-1 SCARB1 KO )
CVCL_C0A3 (Abcam THP-1 SDC4 KO )CVCL_C0A4 (Abcam THP-1 SETD2 KO )CVCL_C0A5 (Abcam THP-1 SLFN11 KO )
CVCL_C0A6 (Abcam THP-1 SMARCAL1 KO )CVCL_C0A7 (Abcam THP-1 SMARCC2 KO )CVCL_C0A8 (Abcam THP-1 SMARCE1 KO )
CVCL_C0A9 (Abcam THP-1 SMURF1 KO )CVCL_C0AA (Abcam THP-1 SMYD2 KO )CVCL_C0AB (Abcam THP-1 SMYD3 KO )
CVCL_C0AC (Abcam THP-1 SOCS3 KO )CVCL_C0AD (Abcam THP-1 SRF KO )CVCL_C0AE (Abcam THP-1 SRPK1 KO )
CVCL_C0AF (Abcam THP-1 STAT4 KO )CVCL_C0AG (Abcam THP-1 STAT5A KO )CVCL_B1AK (Abcam THP-1 STING1 KO )
CVCL_C0AH (Abcam THP-1 STK4 KO )CVCL_C0AI (Abcam THP-1 SUV39H1 KO )CVCL_C0AJ (Abcam THP-1 SUZ12 KO )
CVCL_C0AK (Abcam THP-1 TAPBP KO )CVCL_C0AL (Abcam THP-1 TBK1 KO )CVCL_C0AM (Abcam THP-1 TBP KO )
CVCL_C0AN (Abcam THP-1 TCF7L2 KO )CVCL_C0AP (Abcam THP-1 TFDP1 KO )CVCL_C0AQ (Abcam THP-1 THBS1 KO )
CVCL_C0AR (Abcam THP-1 TIMP3 KO )CVCL_C0AS (Abcam THP-1 TLN1 KO )CVCL_B1AL (Abcam THP-1 TNF KO )
CVCL_C0AT (Abcam THP-1 TNFRSF10B KO )CVCL_C0AU (Abcam THP-1 TNFRSF1B KO )CVCL_C0AV (Abcam THP-1 TP73 KO )
CVCL_C0AW (Abcam THP-1 TRADD KO )CVCL_C0AX (Abcam THP-1 TRAF2 KO )CVCL_B1AM (Abcam THP-1 TREM2 KO )
CVCL_C0AY (Abcam THP-1 TRMT2A KO )CVCL_C0AZ (Abcam THP-1 TWIST1 KO )CVCL_C0B0 (Abcam THP-1 TWIST2 KO )
CVCL_B7TG (Abcam THP-1 TYROBP KO )CVCL_C0B1 (Abcam THP-1 U2AF1 KO )CVCL_C0B2 (Abcam THP-1 UBA1 KO )
CVCL_C0B3 (Abcam THP-1 UBE2D2 KO )CVCL_C0B4 (Abcam THP-1 UCHL5 KO )CVCL_C0B5 (Abcam THP-1 ULBP2 KO )
CVCL_C0B6 (Abcam THP-1 ULBP3 KO )CVCL_C0B7 (Abcam THP-1 UVRAG KO )CVCL_C0B8 (Abcam THP-1 VAV1 KO )
CVCL_C0B9 (Abcam THP-1 VCAN KO )CVCL_C0BA (Abcam THP-1 WDR77 KO )CVCL_C0BB (Abcam THP-1 WNT11 KO )
CVCL_C0BC (Abcam THP-1 YTHDC2 KO )CVCL_C0BD (Abcam THP-1 YTHDF1 KO )CVCL_C0BE (Abcam THP-1 YTHDF3 KO )
CVCL_C0BF (Abcam THP-1 YY1 KO )CVCL_C0BG (Abcam THP-1 ZEB2 KO )CVCL_X687 (BF24 )
CVCL_KB46 (CellSensor NFkB-bla THP-1 )CVCL_KS29 (CellSensor SIE-bla THP-1 )CVCL_KS30 (CellSensor TNFalpha-bla THP-1 )
CVCL_KZ70 (PathHunter THP-1 IkappaB Degradation )CVCL_IR08 (PSC-THP1 )CVCL_A4CA (THP-1 AP1-Luc2 )
CVCL_A4CB (THP-1 CRE-Luc2 )CVCL_A4CD (THP-1 GAS-Luc2 )CVCL_A4CC (THP-1 ISRE-Luc2 )
CVCL_XZ65 (THP-1 NF-kb luciferase reporter )CVCL_A4CE (THP-1 NF-kB-Luc2 )CVCL_DF52 (THP-1 NucLight Red )
CVCL_C3EW (THP-1 Safe Harbor Landing Pad )CVCL_XI47 (THP-1 TLR9 mCherry )CVCL_0R25 (THP-1(NCI) )
CVCL_C0YT (THP-1-Cs5 )CVCL_C0YQ (THP-1-R )CVCL_WI26 (THP-1/AR )
CVCL_4V22 (THP-1/ara-C )CVCL_0R21 (THP-1/DC-SIGN )CVCL_A1RT (THP-1/E )
CVCL_XD94 (THP-1/IL15 )CVCL_XD95 (THP-1/IL21 )CVCL_3426 (THP-1h )
CVCL_3427 (THP-1l )CVCL_C0QX (THP1 GFP-PEAK3 )CVCL_C0QY (THP1 ST-PEAK3 )
CVCL_A8AT (THP1-ASC-GFP )CVCL_X588 (THP1-Blue ISG )CVCL_X589 (THP1-Blue ISG-KD-STING )
CVCL_X585 (THP1-Blue NF-kappaB )CVCL_X599 (THP1-Dual )CVCL_A8BE (THP1-HMGB1-Lucia )
CVCL_X587 (THP1-Lucia ISG )CVCL_X590 (THP1-Lucia NF-kappaB )CVCL_5I77 (THP1-NLRC4 )
CVCL_X601 (THP1-Null )CVCL_A8AK (THP1-Null2 )CVCL_X582 (THP1-Xblue )
CVCL_A0HA (THP18 )
Sex of cell Male
Age at sampling 1Y
Category Cancer cell line
STR profile Source(s): AddexBio; ATCC; CCRID; CLS; Cosmic-CLP; DSMZ; ECACC; Genomics_Center_BCF_Technion; ICLC; JCRB; KCLB; PubMed=11416159; PubMed=25877200; PubMed=35373342; RCB; TKG

Markers:
AmelogeninX,Y
CSF1PO11,13
D1S165616,17
D2S44110,11
D2S133817,18
D3S135815,17
D5S81811,12
D7S82010
D8S117910,14
D10S124814
D12S39118,19
D13S3178,13 (CCRID; DSMZ; RCB; TKG)
13 (AddexBio; ATCC; CLS; Cosmic-CLP; ECACC; Genomics_Center_BCF_Technion; JCRB; KCLB; PubMed=25877200)
D16S53911,12
D18S5113,14
D19S43312.2,13 (Genomics_Center_BCF_Technion)
12.2,13,14 (CCRID)
13 (DSMZ)
D21S1130,31.2
D22S104511,15
DYS39110
FGA24,25
Penta D10,12
Penta E11,15
TH018,9.3
TPOX8,11
vWA16 (AddexBio; ATCC; CCRID; CLS; Cosmic-CLP; ECACC; Genomics_Center_BCF_Technion; ICLC; JCRB; KCLB; PubMed=11416159; PubMed=25877200)
16,17 (DSMZ; RCB; TKG)

Run an STR similarity search on this cell line
Web pages https://en.wikipedia.org/wiki/THP-1_cell_line
https://www.proteinatlas.org/learn/cellines
https://strap.nci.nih.gov/celline_detail.php?sample_id=78
http://www.bowdish.ca/lab/wp-content/uploads/2011/07/THP-1-propagation-culture.pdf
https://web.archive.org/web/20201109215324/www.infarktforschung.de/macrophages_cell_lines.html
https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/t/cell-lines-detail-444.html
https://tcpaportal.org/mclp/
https://read.oecd-ilibrary.org/environment/test-no-442e-in-vitro-skin-sensitisation_9789264264359-en
Publications

PubMed=6970727; DOI=10.1002/ijc.2910260208
Tsuchiya S., Yamabe M., Yamaguchi Y., Kobayashi Y., Konno T., Tada K.
Establishment and characterization of a human acute monocytic leukemia cell line (THP-1).
Int. J. Cancer 26:171-176(1980)

PubMed=6949641
Tsuchiya S., Kobayashi Y., Goto Y., Okumura H., Nakae S., Konno T., Tada K.
Induction of maturation in cultured human monocytic leukemia cells by a phorbol diester.
Cancer Res. 42:1530-1536(1982)

PubMed=6091813; DOI=10.1182/blood.V64.5.1059.1059
Palumbo A., Minowada J., Erikson J., Croce C.M., Rovera G.
Lineage infidelity of a human myelogenous leukemia cell line.
Blood 64:1059-1063(1984)

PubMed=2985879; DOI=10.1016/0145-2126(85)90084-0
Drexler H.G., Gaedicke G., Minowada J.
Isoenzyme studies in human leukemia-lymphoma cell lines -- 1 carboxylic esterase.
Leuk. Res. 9:209-229(1985)

PubMed=3159941; DOI=10.1016/0145-2126(85)90134-1
Drexler H.G., Gaedicke G., Minowada J.
Isoenzyme studies in human leukemia-lymphoma cell lines -- III Beta-hexosaminidase (E.C. 3.2.1.30).
Leuk. Res. 9:549-559(1985)

PubMed=3874327; DOI=10.1016/0145-2126(85)90133-x
Drexler H.G., Gaedicke G., Minowada J.
Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid phosphatase.
Leuk. Res. 9:537-548(1985)

PubMed=2633408; DOI=10.1620/tjem.159.299
Saijo Y., Kumano N., Tokue Y., Satoh K., Oizumi K., Motomiya M.
Characterization of resistance to VP-16 in human leukemic cell line.
Tohoku J. Exp. Med. 159:299-306(1989)

PubMed=1915666; DOI=10.1016/0014-4827(91)90482-A
Limouse M., Manie S., Konstantinova I., Ferrua B., Schaffar L.
Inhibition of phorbol ester-induced cell activation in microgravity.
Exp. Cell Res. 197:82-86(1991)

PubMed=1571549; DOI=10.1182/blood.V79.9.2378.2378
Sugimoto K., Toyoshima H., Sakai R., Miyagawa K., Hagiwara K., Ishikawa F., Takaku F., Yazaki Y., Hirai H.
Frequent mutations in the p53 gene in human myeloid leukemia cell lines.
Blood 79:2378-2383(1992)

PubMed=8558913
Morita S., Tsuchiya S., Fujie H., Itano M., Ohashi Y., Minegishi M., Imaizumi M., Endo M., Takano N., Konno T.
Cell surface c-kit receptors in human leukemia cell lines and pediatric leukemia: selective preservation of c-kit expression on megakaryoblastic cell lines during adaptation to in vitro culture.
Leukemia 10:102-105(1996)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=9379676; DOI=10.1016/S0145-2126(97)00036-2
Sheng X.-M., Kawamura M., Ohnishi H., Ida K., Hanada R., Kojima S., Kobayashi M., Bessho F., Yanagisawa M., Hayashi Y.
Mutations of the RAS genes in childhood acute myeloid leukemia, myelodysplastic syndrome and juvenile chronic myelocytic leukemia.
Leuk. Res. 21:697-701(1997)

PubMed=9510473; DOI=10.1111/j.1349-7006.1998.tb00476.x
Hosoya N., Hangaishi A., Ogawa S., Miyagawa K., Mitani K., Yazaki Y., Hirai H.
Frameshift mutations of the hMSH6 gene in human leukemia cell lines.
Jpn. J. Cancer Res. 89:33-39(1998)

PubMed=9738977; DOI=10.1111/j.1349-7006.1998.tb03275.x
Takizawa J., Suzuki R., Kuroda H., Utsunomiya A., Kagami Y., Joh T., Aizawa Y., Ueda R., Seto M.
Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia.
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Cross-references
Cell line collections Abcam; ab271147
Abcam; ab275477
Abcam; ab281894
AddexBio; C0003024/4956
ATCC; TIB-202
BCRC; 60430
BCRJ; 0234
CCTCC; GDC0100
CLS; 300356
DSMZ; ACC-16
ECACC; 88081201
HIVReagentProgram; ARP-9942
ICLC; HTL97014
IZSLER; BS TCL 138
JCRB; JCRB0112
JCRB; JCRB0112.1
KCB; KCB 200549YJ
KCLB; 40202
NCBI_Iran; C563
RCB; RCB1189
RCB; RCB3686
TKG; TKG 0267
Cell line databases/resources CLO; CLO_0009348
CLO; CLO_0050999
MCCL; MCC:0000461
CLDB; cl4513
CLDB; cl4514
CLDB; cl4515
CLDB; cl4517
CCRID; 1101HUM-PUMC000057
CCRID; 1102HUM-NIFDC00058
CCRID; 3101HUMSCSP567
CCRID; 3101HUMTCHu57
CCRID; 4201HUM-CCTCC00100
Cell_Model_Passport; SIDM01172
Cosmic-CLP; 909771
DepMap; ACH-000146
DSMZCellDive; ACC-16
IGRhCellID; THP1
LINCS_HMS; 50861
LINCS_LDP; LCL-1072
Lonza; 134
Anatomy/cell type resources BTO; BTO:0001370
Biological sample resources BioSample; SAMN03470795
BioSample; SAMN03473256
BioSample; SAMN03473419
BioSample; SAMN10987847
ENCODE; ENCBS248PAQ
ENCODE; ENCBS443IYN
ENCODE; ENCBS461BPB
ENCODE; ENCBS615XLU
ENCODE; ENCBS913QYS
ENCODE; ENCBS980LBL
Chemistry resources ChEMBL-Cells; CHEMBL3307574
ChEMBL-Targets; CHEMBL614245
GDSC; 909771
PharmacoDB; THP1_1593_2019
Encyclopedic resources Wikidata; Q7670282
Experimental variables resources EFO; EFO_0001253
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
GEO; GSM236807
GEO; GSM236843
GEO; GSM482495
GEO; GSM838432
GEO; GSM838433
GEO; GSM887706
GEO; GSM888799
GEO; GSM1374962
GEO; GSM1446742
GEO; GSM1670543
GEO; GSM2141952
GEO; GSM2141956
GEO; GSM2141958
GEO; GSM2141959
GEO; GSM2141962
GEO; GSM2141968
GEO; GSM2141972
GEO; GSM2141974
GEO; GSM2141979
GEO; GSM2141986
GEO; GSM2141987
GEO; GSM2141993
GEO; GSM2141995
GEO; GSM2141998
GEO; GSM2141999
GEO; GSM2142000
GEO; GSM2142004
GEO; GSM2142005
GEO; GSM2142009
GEO; GSM2142011
GEO; GSM2142015
GEO; GSM2142016
GEO; GSM2142019
GEO; GSM2142021
GEO; GSM2142023
GEO; GSM2142024
GEO; GSM2142028
GEO; GSM2142029
GEO; GSM2142030
GEO; GSM2142031
GEO; GSM2142036
GEO; GSM2142037
GEO; GSM2142039
GEO; GSM2142048
GEO; GSM2142049
GEO; GSM2142052
GEO; GSM2142053
GEO; GSM2142055
GEO; GSM2142059
GEO; GSM2142060
Medical resources MeSH; D000074084
Polymorphism and mutation databases Cosmic; 717684
Cosmic; 724818
Cosmic; 787480
Cosmic; 909771
Cosmic; 919122
Cosmic; 924051
Cosmic; 947361
Cosmic; 975303
Cosmic; 991556
Cosmic; 996316
Cosmic; 998748
Cosmic; 1012124
Cosmic; 1037666
Cosmic; 1070694
Cosmic; 1078722
Cosmic; 1089517
Cosmic; 1150901
Cosmic; 1176587
Cosmic; 1181604
Cosmic; 1187864
Cosmic; 1197931
Cosmic; 1278779
Cosmic; 1281356
Cosmic; 1319551
Cosmic; 1476425
Cosmic; 1519163
Cosmic; 1524842
Cosmic; 1601064
Cosmic; 1604863
Cosmic; 2089655
Cosmic; 2131559
Cosmic; 2306241
Cosmic; 2392976
IARC_TP53; 2198
LiGeA; CCLE_181
Progenetix; CVCL_0006
Proteomic databases PRIDE; PRD000345
PRIDE; PXD000328
PRIDE; PXD000953
PRIDE; PXD004034
PRIDE; PXD008516
PRIDE; PXD011690
PRIDE; PXD015039
PRIDE; PXD030304
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update22-Sep-2022
Version number43