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Cellosaurus THP-1 (CVCL_0006)

[Text version]
Cell line name THP-1
Synonyms THP1; THP 1; THPI; THP-1(ATCC); THP-1-O; O-THP-1; Tohoku Hospital Pediatrics-1
Accession CVCL_0006
Resource Identification Initiative To cite this cell line use: THP-1 (RRID:CVCL_0006)
Comments Group: Space-flown cell line (cellonaut).
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: Human Protein Atlas, Cell Atlas panel.
Part of: LL-100 blood cancer cell line panel.
Part of: MD Anderson Cell Lines Project.
Part of: RAS genetic alteration cell panel (ATCC TCP-1031).
Part of: Tumor Immunology Bank (TIB) collection from Salk (transferred to ATCC in 1981).
Population: Japanese.
Biotechnology: Used in the human Cell Line Activation Test (h-CLAT), an in vitro skin sensitization test (PubMed=16311011; PubMed=16337770; PubMed=29901211).
Characteristics: Can differentiate from monocytes into macrophage-like cells upon stimulation with PMA.
Virology: Not susceptible to infection by SARS coronavirus 2 (SARS-CoV-2) (COVID-19) (PubMed=33389257).
Doubling time: 60-70 hours (PubMed=6970727); 26 hours (PubMed=25984343); ~35-50 hours (DSMZ=ACC-16).
Microsatellite instability: Stable (MSS) (PubMed=10739008; PubMed=11226526; Sanger).
Omics: Genomics; DNA methylation analysis.
Omics: Genomics; Whole exome sequencing.
Omics: Phenotyping; Drug screening.
Omics: Phenotyping; shRNA library screening.
Omics: Proteomics; Expression; Large antibody panel staining analysis.
Omics: Proteomics; Expression; Reverse-phase protein array.
Omics: Proteomics; HLA class I peptidome.
Omics: Proteomics; PTM; Glycoproteome.
Omics: Proteomics; Quantitative.
Omics: Transcriptomics; Microarray.
Omics: Transcriptomics; RNAseq.
Omics: Variations; SNP array analysis.
Anecdotal: Have been flown in space on Cosmos-2044 to study the inhibition of phorbol ester-induced cell activation in microgravity (PubMed=1915666).
Caution: NRAS mutation indicated incorrectly as being p.Gly12Ser in PubMed=9379676.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
HLA typing Source: PubMed=22674354
Class I
HLA-AA*02
HLA-BB*15:11
HLA-CC*03
Class II
HLA-DQDQB1*05,06
HLA-DRDRB1*01,15
DRB5*01/02

Source: PubMed=26589293
Class I
HLA-AA*02:01,02:01
HLA-BB*15:11,15:11
HLA-CC*03:03,03:03

Source: CLS=300356
Class I
HLA-AA*02:01:01
HLA-BB*15:11:01
HLA-CC*03:03:01
Class II
HLA-DPDPB1*02:01:02G,04:02:01G
HLA-DQDQA1*01:01:01,01:02:01
DQB1*05:01:01,06:02:01
HLA-DRDRB1*01:01:01,15:01:01

Source: DSMZCellDive=ACC-16
Class I
HLA-AA*02:01:01,24:02:01
HLA-BB*15:11:01,35:01:01
HLA-CC*03:03:01,03:03:01
Class II
HLA-DPDPA1*01:03:01,02:02:02
DPB1*02:01:02,04:02:01
HLA-DQDQB1*05:01:01,06:02:01
HLA-DRDRA*01:01:01,01:01:01
DRB1*01:01:01,15:01:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.3
East Asian, North77.63
East Asian, South20.4
South Asian1.67
European, North0
European, South0
Disease Childhood acute monocytic leukemia (NCIt: C9163)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_5115 (A-THP-1)CVCL_B9W7 (Abcam THP-1 AATF KO)CVCL_B9W8 (Abcam THP-1 ABCB1 KO)
CVCL_B9W9 (Abcam THP-1 ABL1 KO)CVCL_B9WA (Abcam THP-1 ACVR1B KO)CVCL_B9WB (Abcam THP-1 ADGRG1 KO)
CVCL_D2N2 (Abcam THP-1 AGER KO)CVCL_B9WC (Abcam THP-1 AGTR1 KO)CVCL_B9WD (Abcam THP-1 AHR KO)
CVCL_B9WE (Abcam THP-1 AIM2 KO)CVCL_D2N3 (Abcam THP-1 AKR1B1 KO)CVCL_B9WF (Abcam THP-1 ALCAM KO)
CVCL_B9WG (Abcam THP-1 ALKBH1 KO)CVCL_B9WH (Abcam THP-1 ALYREF KO)CVCL_B1A1 (Abcam THP-1 ANPEP KO)
CVCL_D2N4 (Abcam THP-1 ANXA2 KO)CVCL_D2N5 (Abcam THP-1 ANXA5 KO)CVCL_C7EI (Abcam THP-1 APAF1 KO)
CVCL_B9WI (Abcam THP-1 APOBEC3B KO)CVCL_B9WJ (Abcam THP-1 ASAH1 KO)CVCL_B9WK (Abcam THP-1 ATF5 KO)
CVCL_B1A2 (Abcam THP-1 ATG12 KO)CVCL_B1A3 (Abcam THP-1 ATG14 KO)CVCL_B1A4 (Abcam THP-1 ATG16L1 KO)
CVCL_B9WL (Abcam THP-1 ATG3 KO)CVCL_B1A5 (Abcam THP-1 ATG5 KO)CVCL_B1A6 (Abcam THP-1 ATG7 KO)
CVCL_B9WM (Abcam THP-1 ATG9A KO)CVCL_B9WN (Abcam THP-1 BAK1 KO)CVCL_B1A7 (Abcam THP-1 BCL2 KO)
CVCL_B9WP (Abcam THP-1 BMPR2 KO)CVCL_B9WQ (Abcam THP-1 BRD1 KO)CVCL_B9WR (Abcam THP-1 BRD2 KO)
CVCL_B9WS (Abcam THP-1 BRD9 KO)CVCL_B9WT (Abcam THP-1 BTG1 KO)CVCL_B9WU (Abcam THP-1 BTK KO)
CVCL_B9WV (Abcam THP-1 BTRC KO)CVCL_B9WW (Abcam THP-1 C3 KO)CVCL_B1A8 (Abcam THP-1 CASP1 KO)
CVCL_B9WX (Abcam THP-1 CASP3 KO)CVCL_C7EJ (Abcam THP-1 CASP4 KO)CVCL_B1A9 (Abcam THP-1 CASP9 KO)
CVCL_D2N6 (Abcam THP-1 CAST KO)CVCL_B1AA (Abcam THP-1 CCL3 KO)CVCL_B9WY (Abcam THP-1 CCL4 KO)
CVCL_B9WZ (Abcam THP-1 CCR2 KO)CVCL_B9X0 (Abcam THP-1 CCRL2 KO)CVCL_B9X1 (Abcam THP-1 CCL22 KO)
CVCL_B9X2 (Abcam THP-1 CD36 KO)CVCL_D2N7 (Abcam THP-1 CD46 KO)CVCL_B9X3 (Abcam THP-1 CD48 KO)
CVCL_B9X4 (Abcam THP-1 CD58 KO)CVCL_B9X5 (Abcam THP-1 CD59 KO)CVCL_B9X6 (Abcam THP-1 CD81 KO)
CVCL_D2N8 (Abcam THP-1 CES1 KO)CVCL_B1AB (Abcam THP-1 CHI3L1 KO)CVCL_B9X7 (Abcam THP-1 CITED2 KO)
CVCL_B9X8 (Abcam THP-1 CLU KO)CVCL_B9X9 (Abcam THP-1 CMKLR1 KO)CVCL_B9XA (Abcam THP-1 CMTM6 KO)
CVCL_B9XB (Abcam THP-1 CNR2 KO)CVCL_B9XC (Abcam THP-1 CST3 KO)CVCL_B9XD (Abcam THP-1 CTSB KO)
CVCL_D2N9 (Abcam THP-1 CTSG KO)CVCL_B9XE (Abcam THP-1 CTSS KO)CVCL_B9XF (Abcam THP-1 CUL2 KO)
CVCL_B9XG (Abcam THP-1 CUL3 KO)CVCL_D2NA (Abcam THP-1 CUL4A KO)CVCL_B9XH (Abcam THP-1 CUL4B KO)
CVCL_B9XI (Abcam THP-1 CX3CR1 KO)CVCL_B1AC (Abcam THP-1 CXCL10 KO)CVCL_B1AD (Abcam THP-1 CXCR2 KO)
CVCL_B9XJ (Abcam THP-1 CXXC1 KO)CVCL_D2NB (Abcam THP-1 DCK KO)CVCL_B9XK (Abcam THP-1 DCP2 KO)
CVCL_B9XL (Abcam THP-1 DLL1 KO)CVCL_B9XM (Abcam THP-1 DVL3 KO)CVCL_B9XN (Abcam THP-1 EGLN1 KO)
CVCL_B9XP (Abcam THP-1 EHMT2 KO)CVCL_B9XQ (Abcam THP-1 EIF2AK4 KO)CVCL_B9XR (Abcam THP-1 ENG KO)
CVCL_B9XS (Abcam THP-1 EPHB4 KO)CVCL_B9XT (Abcam THP-1 ERAP1 KO)CVCL_B9XU (Abcam THP-1 ETS2 KO)
CVCL_B9XV (Abcam THP-1 EXO1 KO)CVCL_D2NC (Abcam THP-1 EZH2 KO)CVCL_B9XW (Abcam THP-1 FABP4 KO)
CVCL_D5HB (Abcam THP-1 FCER1G KO)CVCL_B9XX (Abcam THP-1 FCGR1A KO)CVCL_D2ND (Abcam THP-1 FDFT1 KO)
CVCL_B9XY (Abcam THP-1 FGF23 KO)CVCL_B9XZ (Abcam THP-1 FKBP5 KO)CVCL_B9Y0 (Abcam THP-1 FOXO1 KO)
CVCL_B9Y1 (Abcam THP-1 FOXO3 KO)CVCL_B9Y2 (Abcam THP-1 FST KO)CVCL_B9Y3 (Abcam THP-1 FTL KO)
CVCL_B9Y4 (Abcam THP-1 FZD7 KO)CVCL_B9Y5 (Abcam THP-1 GAB1 KO)CVCL_D2NE (Abcam THP-1 GCLM KO)
CVCL_D2NF (Abcam THP-1 GGT1 KO)CVCL_D2NG (Abcam THP-1 GHR KO)CVCL_B9Y6 (Abcam THP-1 GLB1 KO)
CVCL_B9Y7 (Abcam THP-1 GPR132 KO)CVCL_D2NH (Abcam THP-1 GSTP1 KO)CVCL_B9Y8 (Abcam THP-1 GZMA KO)
CVCL_B9Y9 (Abcam THP-1 HLA-B KO)CVCL_D2NI (Abcam THP-1 HMMR KO)CVCL_B9YA (Abcam THP-1 HNF1B KO)
CVCL_B9YB (Abcam THP-1 HSPG2 KO)CVCL_B9YC (Abcam THP-1 ID2 KO)CVCL_B9YD (Abcam THP-1 IL17RB KO)
CVCL_B1AE (Abcam THP-1 IL1B KO)CVCL_B9YE (Abcam THP-1 IRAK3 KO)CVCL_D2NJ (Abcam THP-1 ITGA5 KO)
CVCL_B9YF (Abcam THP-1 ITPR3 KO)CVCL_B9YG (Abcam THP-1 JAG1 KO)CVCL_D2NK (Abcam THP-1 JAK2 KO)
CVCL_B9YH (Abcam THP-1 JMJD6 KO)CVCL_B9YI (Abcam THP-1 KAT7 KO)CVCL_B9YJ (Abcam THP-1 KDM1B KO)
CVCL_B9YK (Abcam THP-1 KDM6B KO)CVCL_B9YL (Abcam THP-1 KPNA2 KO)CVCL_B9YM (Abcam THP-1 LAIR1 KO)
CVCL_B9YN (Abcam THP-1 LAMP2 KO)CVCL_B1AF (Abcam THP-1 LATS1 KO)CVCL_B9YP (Abcam THP-1 LDHA KO)
CVCL_B1AG (Abcam THP-1 LGALS9 KO)CVCL_D2NL (Abcam THP-1 LGMN KO)CVCL_B9YQ (Abcam THP-1 LGR6 KO)
CVCL_B9YR (Abcam THP-1 LMNB1 KO)CVCL_D2NM (Abcam THP-1 LOX KO)CVCL_B1AH (Abcam THP-1 LYZ KO)
CVCL_B9YS (Abcam THP-1 MACROH2A1 KO)CVCL_C7EK (Abcam THP-1 MAD1L1 KO)CVCL_B9YT (Abcam THP-1 MAGEA3 KO)
CVCL_B9YU (Abcam THP-1 MAP2K3 KO)CVCL_B9YV (Abcam THP-1 MAP3K3 KO)CVCL_B9YW (Abcam THP-1 MAPK7 KO)
CVCL_D2NN (Abcam THP-1 MARCKS KO)CVCL_B9YX (Abcam THP-1 MBD1 KO)CVCL_B9YY (Abcam THP-1 MBD3 KO)
CVCL_D2NP (Abcam THP-1 MBNL1 KO)CVCL_B9YZ (Abcam THP-1 MME KO)CVCL_B9Z0 (Abcam THP-1 MMP13 KO)
CVCL_C7EL (Abcam THP-1 MMP3 KO)CVCL_B9Z1 (Abcam THP-1 MMP8 KO)CVCL_B9Z2 (Abcam THP-1 MTA3 KO)
CVCL_D2NQ (Abcam THP-1 NAMPT KO)CVCL_B9Z3 (Abcam THP-1 NBR1 KO)CVCL_B9Z4 (Abcam THP-1 NCR3LG1 KO)
CVCL_B9Z5 (Abcam THP-1 NFKB1 KO)CVCL_B9Z6 (Abcam THP-1 NLRC4 KO)CVCL_B9Z7 (Abcam THP-1 NLRP3 KO)
CVCL_B9Z8 (Abcam THP-1 NOTCH3 KO)CVCL_B9Z9 (Abcam THP-1 NOTCH4 KO)CVCL_B9ZA (Abcam THP-1 NQO1 KO)
CVCL_B9ZB (Abcam THP-1 NR1H4 KO)CVCL_B9ZC (Abcam THP-1 NR3C2 KO)CVCL_D2NR (Abcam THP-1 ODC1 KO)
CVCL_D2NS (Abcam THP-1 P2RX7 KO)CVCL_D2NT (Abcam THP-1 P2RY12 KO)CVCL_B9ZD (Abcam THP-1 PDCD1LG2 KO)
CVCL_D2NU (Abcam THP-1 PDIA3 KO)CVCL_D2NV (Abcam THP-1 PGK1 KO)CVCL_B9ZE (Abcam THP-1 PHF8 KO)
CVCL_D2NW (Abcam THP-1 PHGDH KO)CVCL_B9ZF (Abcam THP-1 PIK3CA KO)CVCL_B9ZG (Abcam THP-1 PIK3CD KO)
CVCL_B9ZH (Abcam THP-1 PIK3R4 KO)CVCL_B9ZI (Abcam THP-1 PLA2G4A KO)CVCL_B9ZJ (Abcam THP-1 PLAU KO)
CVCL_D2NX (Abcam THP-1 PLAUR KO)CVCL_B9ZK (Abcam THP-1 PLCB3 KO)CVCL_B9ZL (Abcam THP-1 PLCG1 KO)
CVCL_E7C2 (Abcam THP-1 PLCG2 KO)CVCL_D2NY (Abcam THP-1 POU2F1 KO)CVCL_D1YJ (Abcam THP-1 PRDX6 KO)
CVCL_B9ZM (Abcam THP-1 PRMT7 KO)CVCL_B9ZN (Abcam THP-1 PSEN1 KO)CVCL_C7EM (Abcam THP-1 PSMB9 KO)
CVCL_B9ZP (Abcam THP-1 PTGER4 KO)CVCL_B9ZQ (Abcam THP-1 PTGES2 KO)CVCL_B9ZR (Abcam THP-1 PTK2 KO)
CVCL_D2NZ (Abcam THP-1 PTK2B KO)CVCL_B9ZS (Abcam THP-1 PTP4A3 KO)CVCL_B9ZT (Abcam THP-1 PTPN12 KO)
CVCL_B1AI (Abcam THP-1 PTPN6 KO)CVCL_B9ZU (Abcam THP-1 PUS1 KO)CVCL_D2P0 (Abcam THP-1 RAB5A KO)
CVCL_B9ZV (Abcam THP-1 RAC2 KO)CVCL_C7EN (Abcam THP-1 RBL2 KO)CVCL_D2P1 (Abcam THP-1 RETN KO)
CVCL_B9ZW (Abcam THP-1 RING1 KO)CVCL_B1AJ (Abcam THP-1 RIPK1 KO)CVCL_C7EP (Abcam THP-1 ROCK1 KO)
CVCL_B9ZX (Abcam THP-1 ROCK2 KO)CVCL_B9ZY (Abcam THP-1 ROR2 KO)CVCL_B9ZZ (Abcam THP-1 RUNX2 KO)
CVCL_C0A0 (Abcam THP-1 RYBP KO)CVCL_D2P2 (Abcam THP-1 RYR1 KO)CVCL_C0A1 (Abcam THP-1 S100A8 KO)
CVCL_D2P3 (Abcam THP-1 SATB1 KO)CVCL_C0A2 (Abcam THP-1 SCARB1 KO)CVCL_C0A3 (Abcam THP-1 SDC4 KO)
CVCL_C0A4 (Abcam THP-1 SETD2 KO)CVCL_C7EQ (Abcam THP-1 SKP2 KO)CVCL_D2P4 (Abcam THP-1 SLC12A5 KO)
CVCL_D2P5 (Abcam THP-1 SLC16A1 KO)CVCL_D2P6 (Abcam THP-1 SLC29A1 KO)CVCL_D2P7 (Abcam THP-1 SLC9A1 KO)
CVCL_C0A5 (Abcam THP-1 SLFN11 KO)CVCL_C0A6 (Abcam THP-1 SMARCAL1 KO)CVCL_C0A7 (Abcam THP-1 SMARCC2 KO)
CVCL_C0A8 (Abcam THP-1 SMARCE1 KO)CVCL_C7ER (Abcam THP-1 SMPD1 KO)CVCL_C0A9 (Abcam THP-1 SMURF1 KO)
CVCL_C0AA (Abcam THP-1 SMYD2 KO)CVCL_C0AB (Abcam THP-1 SMYD3 KO)CVCL_C0AC (Abcam THP-1 SOCS3 KO)
CVCL_D2P8 (Abcam THP-1 SPHK1 KO)CVCL_C0AD (Abcam THP-1 SRF KO)CVCL_C0AE (Abcam THP-1 SRPK1 KO)
CVCL_C0AF (Abcam THP-1 STAT4 KO)CVCL_C0AG (Abcam THP-1 STAT5A KO)CVCL_D2P9 (Abcam THP-1 STIM2 KO)
CVCL_B1AK (Abcam THP-1 STING1 KO)CVCL_D2PA (Abcam THP-1 STIP1 KO)CVCL_C0AH (Abcam THP-1 STK4 KO)
CVCL_C0AI (Abcam THP-1 SUV39H1 KO)CVCL_C0AJ (Abcam THP-1 SUZ12 KO)CVCL_E7C4 (Abcam THP-1 SYK KO)
CVCL_C0AK (Abcam THP-1 TAPBP KO)CVCL_C0AL (Abcam THP-1 TBK1 KO)CVCL_C0AM (Abcam THP-1 TBP KO)
CVCL_C0AN (Abcam THP-1 TCF7L2 KO)CVCL_C0AP (Abcam THP-1 TFDP1 KO)CVCL_C0AQ (Abcam THP-1 THBS1 KO)
CVCL_C7ES (Abcam THP-1 TIMP2 KO)CVCL_C0AR (Abcam THP-1 TIMP3 KO)CVCL_C0AS (Abcam THP-1 TLN1 KO)
CVCL_B1AL (Abcam THP-1 TNF KO)CVCL_C0AT (Abcam THP-1 TNFRSF10B KO)CVCL_C0AU (Abcam THP-1 TNFRSF1B KO)
CVCL_C0AV (Abcam THP-1 TP73 KO)CVCL_D2PB (Abcam THP-1 TPM1 KO)CVCL_C0AW (Abcam THP-1 TRADD KO)
CVCL_C0AX (Abcam THP-1 TRAF2 KO)CVCL_C7ET (Abcam THP-1 TRAP1 KO)CVCL_B1AM (Abcam THP-1 TREM2 KO)
CVCL_C0AY (Abcam THP-1 TRMT2A KO)CVCL_D2PC (Abcam THP-1 TUBA4A KO)CVCL_C0AZ (Abcam THP-1 TWIST1 KO)
CVCL_C0B0 (Abcam THP-1 TWIST2 KO)CVCL_C7EU (Abcam THP-1 TXNRD1 KO)CVCL_C7EV (Abcam THP-1 TXNIP KO)
CVCL_D2PD (Abcam THP-1 TYMS KO)CVCL_B7TG (Abcam THP-1 TYROBP KO)CVCL_C0B1 (Abcam THP-1 U2AF1 KO)
CVCL_C0B2 (Abcam THP-1 UBA1 KO)CVCL_C0B3 (Abcam THP-1 UBE2D2 KO)CVCL_C0B4 (Abcam THP-1 UCHL5 KO)
CVCL_D2PE (Abcam THP-1 UCP2 KO)CVCL_C0B5 (Abcam THP-1 ULBP2 KO)CVCL_C0B6 (Abcam THP-1 ULBP3 KO)
CVCL_C0B7 (Abcam THP-1 UVRAG KO)CVCL_C0B8 (Abcam THP-1 VAV1 KO)CVCL_C0B9 (Abcam THP-1 VCAN KO)
CVCL_C0BA (Abcam THP-1 WDR77 KO)CVCL_C0BB (Abcam THP-1 WNT11 KO)CVCL_D2PF (Abcam THP-1 XBP1 KO)
CVCL_D2PG (Abcam THP-1 XDH KO)CVCL_C0BC (Abcam THP-1 YTHDC2 KO)CVCL_C0BD (Abcam THP-1 YTHDF1 KO)
CVCL_C0BE (Abcam THP-1 YTHDF3 KO)CVCL_C0BF (Abcam THP-1 YY1 KO)CVCL_C0BG (Abcam THP-1 ZEB2 KO)
CVCL_X687 (BF24)CVCL_E8DQ (BPS Bioscience THP-1 B2M KO)CVCL_E8DR (BPS Bioscience THP-1 B2M/CIITA dKO)
CVCL_E8DS (BPS Bioscience THP-1 CD36 KO)CVCL_E8DT (BPS Bioscience THP-1 CIITA KO)CVCL_E8DU (BPS Bioscience THP-1 FCGR1A KO)
CVCL_F0PJ (BPS Bioscience THP-1 ISRE-driven luciferase reporter)CVCL_KB46 (CellSensor NFkB-bla THP-1)CVCL_KS29 (CellSensor SIE-bla THP-1)
CVCL_KS30 (CellSensor TNFalpha-bla THP-1)CVCL_E2QA (HyCyte THP-1 hADAP1_p.P14R_c.41C>G)CVCL_E2QB (HyCyte THP-1 hKDM6A_p.A694T_c.2080G>A)
CVCL_D6CN (HyCyte THP-1 KO-hCASP1)CVCL_D6CP (HyCyte THP-1 KO-hCD274)CVCL_D6CQ (HyCyte THP-1 KO-hCD44)
CVCL_E1MY (HyCyte THP-1 KO-hELF4)CVCL_E1MZ (HyCyte THP-1 KO-hGSDMD)CVCL_E1N0 (HyCyte THP-1 KO-hHNRNPA2B1)
CVCL_E1N1 (HyCyte THP-1 KO-hIRAK4)CVCL_E1N2 (HyCyte THP-1 KO-hLAMTOR2)CVCL_E1N3 (HyCyte THP-1 KO-hMCFD2)
CVCL_E1N4 (HyCyte THP-1 KO-hNCF1)CVCL_E1N5 (HyCyte THP-1 KO-hOSM)CVCL_E1N6 (HyCyte THP-1 KO-hSETDB2)
CVCL_E1N7 (HyCyte THP-1 KO-hSMAD3)CVCL_D6CR (HyCyte THP-1 KO-hTHRAP3)CVCL_D6CS (HyCyte THP-1 KO-hTNF)
CVCL_D6CT (HyCyte THP-1 KO-hUSP10)CVCL_E3IS (HyCyte THP-1-Luc)CVCL_KZ70 (PathHunter THP-1 IkappaB Degradation)
CVCL_IR08 (PSC-THP1)CVCL_A4CA (THP-1 AP1-Luc2)CVCL_A4CB (THP-1 CRE-Luc2)
CVCL_A4CD (THP-1 GAS-Luc2)CVCL_E7CQ (THP-1 IQAD biosensor)CVCL_A4CC (THP-1 ISRE-Luc2)
CVCL_XZ65 (THP-1 NF-kb-Luc2 reporter)CVCL_A4CE (THP-1 NF-kB-Luc2)CVCL_B5NS (THP-1 NFAT-Luc2)
CVCL_E2QQ (THP-1 NF-kappaB-eGFP)CVCL_DF52 (THP-1 NucLight Red)CVCL_E7B2 (THP-1 PSMB9-eGFP-His)
CVCL_C3EW (THP-1 Safe Harbor Landing Pad)CVCL_XI47 (THP-1 TLR9 mCherry)CVCL_C8WG (THP-1-EGFP)
CVCL_C8WH (THP-1-Luc)CVCL_0R25 (THP-1(NCI))CVCL_C0YT (THP-1-Cs5)
CVCL_C0YQ (THP-1-R)CVCL_WI26 (THP-1/AR)CVCL_4V22 (THP-1/ara-C)
CVCL_0R21 (THP-1/DC-SIGN)CVCL_A1RT (THP-1/E)CVCL_XD94 (THP-1/IL15)
CVCL_XD95 (THP-1/IL21)CVCL_3426 (THP-1h)CVCL_3427 (THP-1l)
CVCL_D5JL (THP-G1b)CVCL_D5JK (THP-G8)CVCL_C0QX (THP1 GFP-PEAK3)
CVCL_C0QY (THP1 ST-PEAK3)CVCL_A8AT (THP1-ASC-GFP)CVCL_X588 (THP1-Blue ISG)
CVCL_X589 (THP1-Blue ISG-KD-STING)CVCL_X585 (THP1-Blue NF-kappaB)CVCL_E8F3 (THP1-Blue NF-kappaB v2)
CVCL_X599 (THP1-Dual)CVCL_A8BE (THP1-HMGB1-Lucia)CVCL_X587 (THP1-Lucia ISG)
CVCL_X590 (THP1-Lucia NF-kappaB)CVCL_E8F9 (THP1-Lucia NF-kappaB v2)CVCL_5I77 (THP1-NLRC4)
CVCL_X601 (THP1-Null)CVCL_A8AK (THP1-Null2)CVCL_X582 (THP1-XBlue)
CVCL_A0HA (THP18)CVCL_E1CM (Ubigene THP-1 ACOD1 KO)CVCL_E1CN (Ubigene THP-1 ADA2 KO)
CVCL_E1CP (Ubigene THP-1 AHR KO)CVCL_E1CQ (Ubigene THP-1 C15orf48 KO)CVCL_E1CR (Ubigene THP-1 CARD8 KO)
CVCL_E1CS (Ubigene THP-1 CES1 KO)CVCL_E1CT (Ubigene THP-1 CLEC10A KO)CVCL_E1CU (Ubigene THP-1 CLEC4A KO)
CVCL_E1CV (Ubigene THP-1 EGR1 KO)CVCL_E1CW (Ubigene THP-1 GLP1R KO)CVCL_E1CX (Ubigene THP-1 GPNMB KO)
CVCL_E1CY (Ubigene THP-1 GSDMD KO)CVCL_E1CZ (Ubigene THP-1 HERC5 KO)CVCL_E1D0 (Ubigene THP-1 IFI35 KO)
CVCL_E1D1 (Ubigene THP-1 ISG15 KO)CVCL_E1D2 (Ubigene THP-1 MCU KO)CVCL_E1D3 (Ubigene THP-1 MILR1 KO)
CVCL_E1D4 (Ubigene THP-1 NFE2L2 KO)CVCL_E1D5 (Ubigene THP-1 NLRP3 KO)CVCL_E1D6 (Ubigene THP-1 NMI KO)
CVCL_E1D7 (Ubigene THP-1 PIGA KO)CVCL_E1D8 (Ubigene THP-1 PTPN11 KO)CVCL_E1D9 (Ubigene THP-1 RNASE1 KO)
CVCL_E1DA (Ubigene THP-1 SIGLEC9 KO)CVCL_E1DB (Ubigene THP-1 SLAMF7 KO)CVCL_E1DC (Ubigene THP-1 SLC37A4 KO)
CVCL_E1DD (Ubigene THP-1 SLC39A8 KO)CVCL_E1DE (Ubigene THP-1 SLC6A6 KO)CVCL_E1DF (Ubigene THP-1 TCN2 KO)
CVCL_E1DG (Ubigene THP-1 TET2 KO)CVCL_E1DH (Ubigene THP-1 TLR1 KO)CVCL_E1DI (Ubigene THP-1 TLR2 KO)
CVCL_E1DJ (Ubigene THP-1 TLR4 KO)CVCL_E1DK (Ubigene THP-1 TREM2 KO)CVCL_E1DL (Ubigene THP-1 UBA7 KO)
CVCL_E1DM (Ubigene THP-1 USP22 KO)CVCL_E1DN (Ubigene THP-1 VAMP2 KO)CVCL_E1DP (Ubigene THP-1 ZEB1 KO)
Sex of cell Male
Age at sampling 1Y
Category Cancer cell line
STR profile Source(s): AddexBio=C0003024/4956; ATCC=TIB-202; CCRID; CLS=300356; Cosmic-CLP=909771; DSMZ=ACC-16; ECACC=88081201; ICLC=HTL97014; JCRB=JCRB0112; JCRB=JCRB0112.1; KCLB=40202; PubMed=11416159; PubMed=25877200; PubMed=35373342; RCB=RCB1189; Technion Genomics Center; TKG=TKG 0267

Markers:
AmelogeninX,Y
CSF1PO11,13
D1S165616,17
D2S44110,11
D2S133817,18
D3S135815,17
D5S81811,12
D7S82010
D8S117910,14
D10S124814
D12S39118,19
D13S3178,13 (CCRID; DSMZ=ACC-16; JCRB=JCRB0112; RCB=RCB1189; TKG=TKG 0267)
13 (AddexBio=C0003024/4956; ATCC=TIB-202; CLS=300356; Cosmic-CLP=909771; ECACC=88081201; JCRB=JCRB0112.1; KCLB=40202; PubMed=25877200; Technion Genomics Center)
D16S53911,12
D18S5113,14
D19S43312.2,13 (ATCC=TIB-202; Technion Genomics Center)
12.2,13,14 (CCRID)
13 (DSMZ=ACC-16)
D21S1130,31.2
D22S104511,15
DYS39110
FGA24,25
Penta D10,12
Penta E11,15
TH018,9.3
TPOX8,11
vWA16 (AddexBio=C0003024/4956; ATCC=TIB-202; CCRID; CLS=300356; Cosmic-CLP=909771; ECACC=88081201; ICLC=HTL97014; JCRB=JCRB0112.1; KCLB=40202; PubMed=11416159; PubMed=25877200; Technion Genomics Center)
16,17 (DSMZ=ACC-16; JCRB=JCRB0112; RCB=RCB1189; TKG=TKG 0267)

Run an STR similarity search on this cell line
Web pages Info; -; -; http://www.bowdish.ca/lab/wp-content/uploads/2011/07/THP-1-propagation-culture.pdf
Info; -; -; https://web.archive.org/web/20201109215324/www.infarktforschung.de/macrophages_cell_lines.html
Info; HPA; -; https://www.proteinatlas.org/learn/cellines
Info; MCLP; -; https://tcpaportal.org/mclp/
Info; OECD; -; https://read.oecd-ilibrary.org/environment/test-no-442e-in-vitro-skin-sensitisation_9789264264359-en
Info; StRAP; -; https://strap.nci.nih.gov/celline_detail.php?sample_id=78
Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/t/cell-lines-detail-444.html
Info; Wikipedia; -; https://en.wikipedia.org/wiki/THP-1_cell_line
Publications

PubMed=6970727; DOI=10.1002/ijc.2910260208
Shigeru Tsuchiya, Michiko Yamabe, Yoshiki Yamaguchi, Yasuko Kobayashi, Tasuke Konno, Keiya Tada;
Establishment and characterization of a human acute monocytic leukemia cell line (THP-1).
Int. J. Cancer 26:171-176(1980)

PubMed=6949641
Shigeru Tsuchiya, Yasuko Kobayashi, Yoichi Goto, Hidesada Okumura, Shingi Nakae, Tasuke Konno, Keiya Tada;
Induction of maturation in cultured human monocytic leukemia cells by a phorbol diester.
Cancer Res. 42:1530-1536(1982)

PubMed=6091813; DOI=10.1182/blood.V64.5.1059.1059
Antonio Palumbo, Jun Minowada, Jan Erikson, Carlo Maria Croce, Giovanni Rovera;
Lineage infidelity of a human myelogenous leukemia cell line.
Blood 64:1059-1063(1984)

PubMed=2985879; DOI=10.1016/0145-2126(85)90084-0
Hans Gunther Drexler, Gerhard Gaedicke, Jun Minowada;
Isoenzyme studies in human leukemia-lymphoma cell lines -- 1 Carboxylic esterase.
Leuk. Res. 9:209-229(1985)

PubMed=3159941; DOI=10.1016/0145-2126(85)90134-1
Hans Gunther Drexler, Gerhard Gaedicke, Jun Minowada;
Isoenzyme studies in human leukemia-lymphoma cell lines -- III Beta-hexosaminidase (E.C. 3.2.1.30).
Leuk. Res. 9:549-559(1985)

PubMed=3874327; DOI=10.1016/0145-2126(85)90133-x
Hans Gunther Drexler, Gerhard Gaedicke, Jun Minowada;
Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid phosphatase.
Leuk. Res. 9:537-548(1985)

PubMed=2633408; DOI=10.1620/tjem.159.299
Yasuo Saijo, Nobuko Kumano, Yutaka Tokue, Ken Satoh, Kotaro Oizumi, Masakichi Motomiya;
Characterization of resistance to VP-16 in human leukemic cell line.
Tohoku J. Exp. Med. 159:299-306(1989)

PubMed=1915666; DOI=10.1016/0014-4827(91)90482-A
Martine Limouse, Serge Manie, Irina Konstantinova, Bernard Ferrua, Laurence Schaffar;
Inhibition of phorbol ester-induced cell activation in microgravity.
Exp. Cell Res. 197:82-86(1991)

PubMed=1571549; DOI=10.1182/blood.V79.9.2378.2378
Koichi Sugimoto, Hideo Toyoshima, Ryuichi Sakai, Kiyoshi Miyagawa, Koichi Hagiwara, Fuyuki Ishikawa, Fumimaro Takaku, Yoshio Yazaki, Hisamaru Hirai;
Frequent mutations in the p53 gene in human myeloid leukemia cell lines.
Blood 79:2378-2383(1992)

PubMed=8558913
S. Morita, S. Tsuchiya, Hiromi Fujie, Masayuki Itano, Yoshiyuki Ohashi, Masayoshi Minegishi, Masue Imaizumi, M. Endo, Nagako Takano, Tasuke Konno;
Cell surface c-kit receptors in human leukemia cell lines and pediatric leukemia: selective preservation of c-kit expression on megakaryoblastic cell lines during adaptation to in vitro culture.
Leukemia 10:102-105(1996)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Li-Qun Jia, Motonobu Osada, Chikashi Ishioka, Makio Gamo, Shuntaro Ikawa, Takao Suzuki, Hideki Shimodaira, Tomohito Niitani, Toshio Kudo, Mitoshi Akiyama, Narimiti Kimura ...Show all 18 authors... , Mitsuyoshi Matsuo, Hiroshi Mizusawa, Noriho Tanaka, Hideki Koyama, Masayoshi Namba, Ryunosuke Kanamaru, Toshio Kuroki; Show fewer authors
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=9379676; DOI=10.1016/S0145-2126(97)00036-2
Xiao-Ming Sheng, Machiko Kawamura, Hiroaki Ohnishi, Kohmei Ida, Ryoji Hanada, Seiji Kojima, Miyuki Kobayashi, Fumio Bessho, Masayoshi Yanagisawa, Yasuhide Hayashi;
Mutations of the RAS genes in childhood acute myeloid leukemia, myelodysplastic syndrome and juvenile chronic myelocytic leukemia.
Leuk. Res. 21:697-701(1997)

PubMed=9510473; DOI=10.1111/j.1349-7006.1998.tb00476.x; PMCID=PMC5921588
Noriko Hosoya, Akira Hangaishi, Seishi Ogawa, Kiyoshi Miyagawa, Kinuko Mitani, Yoshio Yazaki, Hisamaru Hirai;
Frameshift mutations of the hMSH6 gene in human leukemia cell lines.
Jpn. J. Cancer Res. 89:33-39(1998)

PubMed=9738977; DOI=10.1111/j.1349-7006.1998.tb03275.x; PMCID=PMC5921886
Jun Takizawa, Ritsuro Suzuki, Hiroyuki Kuroda, Atae Utsunomiya, Yoshitoyo Kagami, Tatsuroh Joh, Yoshifusa Aizawa, Ryuzo Ueda, Masao Seto;
Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia.
Jpn. J. Cancer Res. 89:712-718(1998)

PubMed=10223614; DOI=10.1620/tjem.186.99
Tsuyoshi Tominaga, Masanori Suzuki, Hisaaki Saeki, Seiki Matsuno, Takehiko Tachibana, Toshio Kudo;
Establishment of an activated macrophage cell line, A-THP-1, and its properties.
Tohoku J. Exp. Med. 186:99-119(1998)

PubMed=10739008; DOI=10.1016/S0145-2126(99)00182-4
Kaoru Inoue, Takashi Kohno, Satoshi Takakura, Yasuhide Hayashi, Hideaki Mizoguchi, Jun Yokota;
Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines.
Leuk. Res. 24:255-262(2000)

PubMed=11066077; DOI=10.1002/1098-2264(2000)9999:9999<::AID-GCC1040>3.0.CO;2-Z
Maria D. Odero, Nancy J. Zeleznik-Le, Vandana Chinwalla, Janet Davison Rowley;
Cytogenetic and molecular analysis of the acute monocytic leukemia cell line THP-1 with an MLL-AF9 translocation.
Genes Chromosomes Cancer 29:333-338(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Hans Gunther Drexler;
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=11226526; DOI=10.1016/S0145-2126(00)00121-1
Kaoru Inoue, Takashi Kohno, Satoshi Takakura, Yasuhide Hayashi, Hideaki Mizoguchi, Jun Yokota;
Corrigendum to: Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines Leukemia Research 24 (2000), 255-262.
Leuk. Res. 25:275-278(2001)

PubMed=11414198; DOI=10.1007/s004320000207
Harald Lahm, Sabine Andre, Andreas Hoeflich, Jurgen R. Fischer, Bernard Sordat, Herbert Kaltner, Eckhard Wolf, Hans-Joachim Gabius;
Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures.
J. Cancer Res. Clin. Oncol. 127:375-386(2001)

PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459
John R.W. Masters, Jim A. Thomson, Bernadette Daly-Burns, Yvonne A. Reid, Wilhelm Gerhard Dirks, Phil Packer, Lorraine H. Toji, Tadao Ohno, Hideyuki Tanabe, Colin Francis Arlett, Lloyd R. Kelland ...Show all 16 authors... , Maureen Harrison, Arvind K. Virmani, Timothy H. Ward, Karen L. Ayres, Paul G. Debenham; Show fewer authors
Short tandem repeat profiling provides an international reference standard for human cell lines.
Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001)

PubMed=12068308; DOI=10.1038/nature00766
Helen R. Davies, Graham Robert Bignell, Charles Cox, Philip J. Stephens, Sarah Edkins, Sheila Clegg, Jon W. Teague, Hayley Woffendin, Mathew J. Garnett, William Bottomley, Neil Davis ...Show all 52 authors... , Ed Dicks, Rebecca Ewing, Yvonne Floyd, Kristian Gray, Sarah Hall, Rachel Hawes, Jaime Hughes, Vivian Kosmidou, Andrew Menzies, Catherine Mould, Adrian Parker, Claire Stevens, Stephen Watt, Steven Hooper, Rebecca Wilson, Hiran Jayatilake, Barry Austin Gusterson, Colin S. Cooper, Janet M. Shipley, Darren Hargrave, Kathy Pritchard-Jones, Norman J. Maitland, Georgia Chenevix-Trench, Gregory J. Riggins, Darell Doty Bigner, Giuseppe Palmieri, Antonio Cossu, Adrienne M. Flanagan, Andrew Nicholson, Judy W.C. Ho, Suet Yi Leung, Siu Tsan Yuen, Barbara L. Weber, Hilliard Foster Seigler, Timothy L. Darrow, Hugh F. Paterson, Richard Marais, Christopher John Marshall, Richard Wooster, Michael Rudolf Stratton, P. Andrew Futreal; Show fewer authors
Mutations of the BRAF gene in human cancer.
Nature 417:949-954(2002)

PubMed=14504097; DOI=10.1182/blood-2003-02-0418
Takeshi Taketani, Tomohiko Taki, Kanji Sugita, Yoshiyuki Furuichi, Eiichi Ishii, Ryoji Hanada, Masahiro Tsuchida, Kenichi Sugita, Kohmei Ida, Yasuhide Hayashi;
FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy.
Blood 103:1085-1088(2004)

PubMed=14671638; DOI=10.1038/sj.leu.2403236
Hans Gunther Drexler, Hilmar Quentmeier, Roderick A.F. MacLeod;
Malignant hematopoietic cell lines: in vitro models for the study of MLL gene alterations.
Leukemia 18:227-232(2004)

PubMed=15843827; DOI=10.1038/sj.leu.2403749
Anna K. Hagstrom-Andersson, Patrik Eden, David Lindgren, Jens Nilsson, Carin Lassen, Jesper Heldrup, Magnus Fontes, Ake Borg, Felix Mitelman, Bertil Johansson, Mattias Hoglund, Thoas Fioretos;
Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.
Leukemia 19:1042-1050(2005)

PubMed=16311011; DOI=10.1016/j.tiv.2005.10.012
Takao Ashikaga, Yukiko Yoshida, Morihiko Hirota, Katsurako Yoneyama, Hiroshi Itagaki, Hitoshi Sakaguchi, Masaaki Miyazawa, Yuichi Ito, Hiroyuki Suzuki, Hidekazu Toyoda;
Development of an in vitro skin sensitization test using human cell lines: the human Cell Line Activation Test (h-CLAT). I. Optimization of the h-CLAT protocol.
Toxicol. In Vitro 20:767-773(2006)

PubMed=16337770; DOI=10.1016/j.tiv.2005.10.014
Hitoshi Sakaguchi, Takao Ashikaga, Masaaki Miyazawa, Yukiko Yoshida, Yuichi Ito, Katsurako Yoneyama, Morihiko Hirota, Hiroshi Itagaki, Hidekazu Toyoda, Hiroyuki Suzuki;
Development of an in vitro skin sensitization test using human cell lines; human Cell Line Activation Test (h-CLAT). II. An inter-laboratory study of the h-CLAT.
Toxicol. In Vitro 20:774-784(2006)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Hilmar Quentmeier, Roderick A.F. MacLeod, Margarete Zaborski, Hans Gunther Drexler;
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=16957166; DOI=10.1369/jhc.6A7001.2006; PMCID=PMC3958123
Ann-Catrin Andersson, Sara Stromberg, Helena Backvall, Caroline Kampf, Mathias Uhlen, Kenneth Wester, Fredrik Ponten;
Analysis of protein expression in cell microarrays: a tool for antibody-based proteomics.
J. Histochem. Cytochem. 54:1413-1423(2006)

PubMed=19220422; DOI=10.1111/j.1600-0609.2009.01211.x
Shimeru Kamihira, Chiharu Terada, Daisuke Sasaki, Katsunori Yanagihara, Kunihiro Tsukasaki, Hiroo Hasegawa, Yasuaki Yamada;
Aberrant p53 protein expression and function in a panel of hematopoietic cell lines with different p53 mutations.
Eur. J. Haematol. 82:301-307(2009)

PubMed=19377474; DOI=10.1038/ng.375; PMCID=PMC6711855
Harukazu Suzuki, Alistair R.R. Forrest, Erik van Nimwegen, Carsten O. Daub, Piotr Jan Balwierz, Katharine M. Irvine, Timo Lassmann, Timothy Ravasi, Yuki Hasegawa, Michiel J.L. de Hoon, Shintaro Katayama ...Show all 160 authors... , Kate Schroder, Piero Carninci, Yasuhiro Tomaru, Mutsumi Kanamori-Katayama, Atsutaka Kubosaki, Altuna Akalin, Yoshinari Ando, Erik Arner, Maki Asada, Hiroshi Asahara, Timothy Lawrence Bailey, Vladimir B. Bajic, Denis Bauer, Anthony G. Beckhouse, Nicolas Bertin, Johan L.M. Bjorkegren, Frank Brombacher, Erika Bulger, Alistair M. Chalk, Joe Chiba, Nicole Cloonan, Adam Dawe, Josee Dostie, Par G. Engstrom, Magbubah Essack, Geoffrey J. Faulkner, J. Lynn Fink, David Fredman, Ko Fujimori, Masaaki Furuno, Takashi Gojobori, Julian Gough, Sean M. Grimmond, Mika Gustafsson, Megumi Hashimoto, Takehiro Hashimoto, Mariko Hatakeyama, Susanne Heinzel, Winston Alexander Hide, Oliver Hofmann, Michael Hornquist, Lukasz Huminiecki, Kazuho Ikeo, Naoko Imamoto, Satoshi Inoue, Yusuke Inoue, Ryoko Ishihara, Takao Iwayanagi, Anders Jacobsen, Mandeep Kaur, Hideya Kawaji, Markus C. Kerr, Ryuichiro Kimura, Syuhei Kimura, Yasumasa Kimura, Hiroaki Kitano, Hisashi Koga, Toshio Kojima, Shinji Kondo, Takeshi Konno, Anders Krogh, Adele Kruger, Ajit Kumar, Boris Lenhard, Andreas Lennartsson, Morten Lindow, Marina Lizio, Cameron MacPherson, Norihiro Maeda, Christopher A. Maher, Monique Maqungo, Jessica Mar, Nicholas A. Matigian, Hideo Matsuda, John Stanley Mattick, Stuart Meier, Sei Miyamoto, Etsuko Miyamoto-Sato, Kazuhiko Nakabayashi, Yutaka Nakachi, Mika Nakano, Sanne Nygaard, Toshitsugu Okayama, Yasushi Okazaki, Haruka Okuda-Yabukami, Valerio Orlando, Jun Otomo, Mikhail Pachkov, Nikolai Petrovsky, Charles Plessy, John Quackenbush, Aleksandar Radovanovic, Michael Rehli, Rintaro Saito, Albin Sandelin, Sebastian Schmeier, Christian Schonbach, Ariel S. Schwartz, Colin A. Semple, Miho Sera, Jessica Severin, Katsuhiko Shirahige, Cas Simons, George St Laurent, Masanori Suzuki, Takahiro Suzuki, Matthew J. Sweet, Ryan J. Taft, Shizu Takeda, Yoichi Takenaka, Kai Tan, Martin S. Taylor, Rohan David Teasdale, Jesper Tegner, Sarah Amalia Teichmann, Eivind Valen, Claes Wahlestedt, Kazunori Waki, Andrew Waterhouse, Christine Anne Wells, Ole Winther, Linda Wu, Kazumi Yamaguchi, Hiroshi Yanagawa, Jun Yasuda, Mihaela Zavolan, David Arthur Hume, Takahiro Arakawa, Shiro Fukuda, Kengo Imamura, Chikatoshi Kai, Ai Kaiho, Tsugumi Kawashima, Chika Kawazu, Yayoi Kitazume, Miki Kojima, Hisashi Miura, Kayoko Murakami, Mitsuyoshi Murata, Noriko Ninomiya, Hiromi Nishiyori, Shohei Noma, Chihiro Ogawa, Takuma Sano, Christophe Simon, Michihira Tagami, Yukari Takahashi, Jun Kawai, Yoshihide Hayashizaki; Show fewer authors
FANTOM Consortium
Riken Omics Science Center
The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line.
Nat. Genet. 41:553-562(2009)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
S. Michael Rothenberg, Gayatry Mohapatra, Miguel N. Rivera, Daniel Winokur, Patricia Greninger, Mai Nitta, Peter M. Sadow, Gaya Sooriyakumar, Brian W. Brannigan, Matthew J. Ulman, Rushika M. Perera ...Show all 22 authors... , Rui Wang, Angela Tam, Xiao-Jun Ma, Mark Erlander, Dennis C. Sgroi, James W. Rocco, Mark W. Lingen, Ezra E.W. Cohen, David Neil Louis, Jeffrey Settleman, Daniel Arie Haber; Show fewer authors
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22645513; DOI=10.3389/fendo.2011.00089; PMCID=PMC3355855
Michaela Keuper, Anna Dzyakanchuk, Kurt E. Amrein, Martin Wabitsch, Pamela Fischer-Posovszky;
THP-1 macrophages and SGBS adipocytes -- a new human in vitro model system of inflamed adipose tissue.
Front. Endocrinol. 2:89.1-89.8(2011)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Jordi Ginesta Barretina, Giordano Caponigro, Nicolas Stransky, Kavitha Venkatesan, Adam A. Margolin, Sungjoon Kim, Christopher J. Wilson, Joseph Lehar, Gregory V. Kryukov, Dmitriy Sonkin, Anupama Reddy ...Show all 61 authors... , Manway Liu, Lauren Murray, Michael F. Berger, John E. Monahan, Paula Morais, Jodi Meltzer, Adam Korejwa, Judit Jane-Valbuena, Felipa A. Mapa, Joseph Thibault, Eva Bric-Furlong, Pichai Raman, Aaron Shipway, Ingo H. Engels, Jill Cheng, Guo-Ying K. Yu, Jian-Jun Yu, Peter Aspesi Jr., Melanie de Silva, Kalpana Jagtap, Michael D. Jones, Li Wang, Charles Hatton, Emanuele Palescandolo, Supriya Gupta, Scott Mahan, Carrie Sougnez, Robert C. Onofrio, Ted Liefeld, Laura E. MacConaill, Wendy Winckler, Michael Reich, Nan-Xin Li, Jill P. Mesirov, Stacey B. Gabriel, Gad Getz, Kristin Ardlie, Vivien Chan, Vic E. Myer, Barbara L. Weber, Jeff Porter, Markus Warmuth, Peter Finan, Jennifer L. Harris, Matthew Langer Meyerson, Todd Robert Golub, Michael P. Morrissey, William Raj Sellers, Robert Schlegel, Levi Alexander Garraway; Show fewer authors
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22481983; DOI=10.2174/1874091X01206010016; PMCID=PMC3314867
Vinita Chauhan, Matthew Howland, Ruth C. Wilkins;
Effects of alpha-particle radiation on microRNA responses in human cell-lines.
Open Biochem. J. 6:16-22(2012)

PubMed=23097634; DOI=10.1100/2012/205038; PMCID=PMC3477555
Vinita Chauhan, Matthew Howland;
Genomic profiling of a human leukemic monocytic cell-line (THP-1) exposed to alpha particle radiation.
ScientificWorldJournal 2012:205038.1-205038.9(2012)

PubMed=22674354; DOI=10.1002/ijc.27661
Richard Battle, Katherine Poole, Sarah Haywood-Small, Brendan Clark, Margot Nicola Woodroofe;
Molecular characterisation of the monocytic cell line THP-1 demonstrates a discrepancy with the documented HLA type.
Int. J. Cancer 132:246-247(2013)

PubMed=23955599; DOI=10.1038/ng.2731
Ayana Kon, Lee-Yung Shih, Masashi Minamino, Masashi Sanada, Yuichi Shiraishi, Yasunobu Nagata, Ken-ichi Yoshida, Yusuke Okuno, Masashige Bando, Ryuichiro Nakato, Shumpei Ishikawa ...Show all 41 authors... , Aiko Sato-Otsubo, Genta Nagae, Aiko Nishimoto, Claudia Haferlach, Daniel Nowak, Yusuke Sato, Tamara Alpermann, Masao Nagasaki, Teppei Shimamura, Hiroko Tanaka, Kenichi Chiba, Ryo Yamamoto, Tomoyuki Yamaguchi, Makoto Otsu, Naoshi Obara, Mamiko Sakata-Yanagimoto, Tsuyoshi Nakamaki, Ken Ishiyama, Florian Nolte, Wolf-Karsten Hofmann, Shuichi Miyawaki, Shigeru Chiba, Hiraku Mori, Hiromitsu Nakauchi, Harold Phillip Koeffler, Hiroyuki Aburatani, Torsten Haferlach, Katsuhiko Shirahige, Satoru Miyano, Seishi Ogawa; Show fewer authors
Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms.
Nat. Genet. 45:1232-1237(2013)

PubMed=24368162; DOI=10.1016/j.exphem.2013.12.004
Piyanuch Sripayap, Tadashi Nagai, Mitsuyo Uesawa, Hiroyuki Kobayashi, Tomonori Tsukahara, Ken Ohmine, Kazuo Muroi, Keiya Ozawa;
Mechanisms of resistance to azacitidine in human leukemia cell lines.
Exp. Hematol. 42:294-306.e2(2014)

PubMed=25130606; DOI=10.1016/j.intimp.2014.08.002
Wasaporn Chanput, Jurriaan J. Mes, Harry J. Wichers;
THP-1 cell line: an in vitro cell model for immune modulation approach.
Int. Immunopharmacol. 23:37-45(2014)

PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652
Glenn S. Cowley, Barbara A. Weir, Francisca Vazquez, Pablo Tamayo, Justine A. Scott, Scott Rusin, Alexandra East-Seletsky, Levi D. Ali, William F.J. Gerath, Sarah E. Pantel, Patrick Hall Lizotte ...Show all 40 authors... , Guo-Zhi Jiang, Jessica Hsiao, Aviad Tsherniak, Elizabeth Dwinell, Simon Aoyama, Michael Okamoto, William Harrington, Ellen T. Gelfand, Thomas M. Green, Mark J. Tomko, Shuba Gopal, Terence C. Wong, Hu-Bo Li, Sara Howell, Nicolas Stransky, Ted Liefeld, Dongkeun Jang, Jonathan Bistline, Barbara Hill Meyers, Scott Allen Armstrong, Kenneth Carl Anderson, Kimberly Stegmaier, Michael Reich, David Pellman, Jesse S. Boehm, Jill P. Mesirov, Todd Robert Golub, David E. Root, William Chun Hahn; Show fewer authors
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Sci. Data 1:140035.1-140035.12(2014)

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Christiaan Klijn, Steffen Durinck, Eric W. Stawiski, Peter M. Haverty, Zhao-Shi Jiang, Han-Bin Liu, Jeremiah Degenhardt, Oleg Mayba, Florian Gnad, Jin-Feng Liu, Gregoire Pau ...Show all 30 authors... , Jens Reeder, Yi Cao, Kiran Mukhyala, Suresh K. Selvaraj, Ma-Mie Yu, Gregory J. Zynda, Matthew J. Brauer, Thomas D. Wu, Robert Clifford Gentleman, Gerard Manning, Robert L. Yauch, Richard Bourgon, David Stokoe, Zora Modrusan, Richard M. Neve, Frederic J. de Sauvage, Jeffrey Settleman, Somasekar Seshagiri, Ze-Min Zhang; Show fewer authors
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Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Ma-Mie Yu, Suresh K. Selvaraj, May M.Y. Liang-Chu, Sahar Aghajani, Matthew Busse, Jean Yuan, Genee Lee, Franklin V. Peale, Christiaan Klijn, Richard Bourgon, Joshua S. Kaminker, Richard M. Neve;
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Jelle Scholtalbers, Sebastian Boegel, Thomas Bukur, Marius Byl, Sebastian Goerges, Patrick Sorn, Martin Loewer, Ugur Sahin, John C. Castle;
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=29787063; DOI=10.1007/978-3-319-16104-4_14
Wasaporn Chanput, Vera Peters, Harry J. Wichers;
THP-1 and U937 cells.
(In book chapter) The impact of food bioactives on health. In vitro and ex vivo models; Verhoeckx, Kitty & Cotter, Paul David & Lopez-Exposito, Ivan & Kleiveland, Charlotte Ramstad & Lea, Tor & Mackie, Alan Robert & Requena, Teresa & Swiatecka, Dominika & Wichers, Harry J. (eds.); pp.147-159; Springer; Cham; Switzerland (2015)

PubMed=26421875; DOI=10.1089/ten.TEC.2015.0188
Hironori Yamazoe, Yoshihisa Hagihara, Hisayuki Kobayashi;
Multicomponent coculture system of cancer cells and two types of stromal cells for in vitro evaluation of anticancer drugs.
Tissue Eng. Part C. Methods 22:20-29(2016)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Francesco Iorio, Theo A. Knijnenburg, Daniel J. Vis, Graham Robert Bignell, Michael Patrick Menden, Michael Schubert, Nanne Aben, Emanuel Goncalves, Syd Barthorpe, Howard Lightfoot, Thomas Cokelaer ...Show all 39 authors... , Patricia Greninger, Ewald van Dyk, Han Chang, Heshani de Silva, Holger Heyn, Xian-Ming Deng, Regina K. Egan, Qing-Song Liu, Tatiana Mironenko, Xeni Mitropoulos, Laura Richardson, Jin-Hua Wang, Ting-Hu Zhang, Sebastian Moran, Sergi Sayols, Maryam Soleimani, David Tamborero, Nuria Lopez-Bigas, Petra Ross-Macdonald, Manel Esteller, Nathanael S. Gray, Daniel Arie Haber, Michael Rudolf Stratton, Cyril Henri Benes, Lodewyk F.A. Wessels, Julio Saez-Rodriguez, Ultan McDermott, Mathew J. Garnett; Show fewer authors
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28109323; DOI=10.1186/s13045-017-0396-0; PMCID=PMC5251306
Riccardo Masetti, Salvatore Nicola Bertuccio, Annalisa Astolfi, Francesca Chiarini, Annalisa Lonetti, Valentina Indio, Matilde De Luca, Jessica Bandini, Salvatore Serravalle, Monica Franzoni, Martina Pigazzi ...Show all 15 authors... , Alberto Maria Martelli, Giuseppe Basso, Franco Locatelli, Andrea Pession; Show fewer authors
Hh/Gli antagonist in acute myeloid leukemia with CBFA2T3-GLIS2 fusion gene.
J. Hematol. Oncol. 10:26.1-26.5(2017)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Jun Li, Wei Zhao, Rehan Akbani, Wen-Bin Liu, Zhen-Lin Ju, Shi-Yun Ling, Christopher P. Vellano, Paul Roebuck, Qing-Hua Yu, A. Karina Eterovic, Lauren Averett Byers ...Show all 25 authors... , Michael A. Davies, Wan-Leng Deng, Y.N. Vashisht Gopal, Guo Chen, Erika Maria von Euw, Dennis Joseph Slamon, Dylan Conklin, John Victor Heymach, Adi F. Gazdar, John D. Minna, Jeffrey N. Myers, Yi-Ling Lu, Gordon B. Mills, Han Liang; Show fewer authors
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Cancer Cell 31:225-239(2017)

PubMed=28404994; DOI=10.1038/s41598-017-00828-y; PMCID=PMC5429802
Mario M. Muller, Roland Lehmann, Tilman E. Klassert, Stella Reifenstein, Theresia Conrad, Christoph Moore, Anna Kuhn, Andrea Behnert, Reinhard Guthke, Dominik Driesch, Hortense Slevogt;
Global analysis of glycoproteins identifies markers of endotoxin tolerant monocytes and GPR84 as a modulator of TNFalpha expression.
Sci. Rep. 7:838-838(2017)

PubMed=29169185; DOI=10.14573/altex.1607191
Stephanie Kletting, Sarah Barthold, Urska Repnik, Gareth Wyn Griffiths, Brigitta Loretz, Nicole Schneider-Daum, Cristiane de Souza Carvalho-Wodarz, Claus-Michael Lehr;
Co-culture of human alveolar epithelial (hAELVi) and macrophage (THP-1) cell lines.
ALTEX 35:211-222(2018)

PubMed=29901211; DOI=10.14573/altex.1710051
Alexander Edwards, Lottie Roscoe, Christopher Longmore, Fiona Bailey, Bushra Sim, Carol Treasure;
Adaptation of the human Cell Line Activation Test (h-CLAT) to animal-product-free conditions.
ALTEX 35:477-488(2018)

PubMed=30285677; DOI=10.1186/s12885-018-4840-5; PMCID=PMC6167786
Kar-Tong Tan, Ling-Wen Ding, Qiao-Yang Sun, Zhen-Tang Lao, Wenwen Chien, Xi Ren, Jin-Fen Xiao, Xin-Yi Loh, Liang Xu, Michael Lill, Anand Mayakonda ...Show all 14 authors... , De-Chen Lin, Henry He Yang, Harold Phillip Koeffler; Show fewer authors
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
BMC Cancer 18:940.1-940.13(2018)

PubMed=30629668; DOI=10.1371/journal.pone.0210404; PMCID=PMC6328144
Cord C. Uphoff, Claudia Pommerenke, Sabine A. Denkmann, Hans Gunther Drexler;
Screening human cell lines for viral infections applying RNA-Seq data analysis.
PLoS ONE 14:e0210404.1-e0210404.22(2019)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Julie Dutil, Zhi-Hua Chen, Alvaro N.A. Monteiro, Jamie K. Teer, Steven A. Eschrich;
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Mahmoud Ghandi, Franklin W. Huang, Judit Jane-Valbuena, Gregory V. Kryukov, Christopher C. Lo, E. Robert McDonald 3rd, Jordi Ginesta Barretina, Ellen T. Gelfand, Craig M. Bielski, Hao-Xin Li, Kevin Hu ...Show all 68 authors... , Alexander Y. Andreev-Drakhlin, Jaegil Kim, Julian M. Hess, Brian J. Haas, Francois Aguet, Barbara A. Weir, Michael V. Rothberg, Brenton R. Paolella, Michael Scott Lawrence, Rehan Akbani, Yi-Ling Lu, Hong L. Tiv, Prafulla C. Gokhale, Antoine de Weck, Ali Amin Mansour, Coyin Oh, Juliann Shih, Kevin Hadi, Yanay Rosen, Jonathan Bistline, Kavitha Venkatesan, Anupama Reddy, Dmitriy Sonkin, Manway Liu, Joseph Lehar, Joshua M. Korn, Dale A. Porter, Michael D. Jones, Javad Golji, Giordano Caponigro, Jordan E. Taylor, Caitlin M. Dunning, Amanda L. Creech, Allison C. Warren, James M. McFarland, Mahdi Zamanighomi, Audrey Kauffmann, Nicolas Stransky, Marcin Imielinski, Yosef E. Maruvka, Andrew D. Cherniack, Aviad Tsherniak, Francisca Vazquez, Jacob D. Jaffe, Andrew Alan Lane, David M. Weinstock, Cory M. Johannessen, Michael P. Morrissey, Frank Stegmeier, Robert Schlegel, William Chun Hahn, Gad Getz, Gordon B. Mills, Jesse S. Boehm, Todd Robert Golub, Levi Alexander Garraway, William Raj Sellers; Show fewer authors
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Nature 569:503-508(2019)

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Cross-references
Cell line collections (Providers) Abcam; ab271147
Abcam; ab275477
Abcam; ab281894
AddexBio; C0003024/4956
ATCC; TIB-202
BCRC; 60430
BCRJ; 0234
BEI_Resources; ARP-9942
CCTCC; GDC0100
CLS; 300356
DSMZ; ACC-16
ECACC; 88081201
ICLC; HTL97014
IZSLER; BS TCL 138
JCRB; JCRB0112
JCRB; JCRB0112.1
KCB; KCB 200549YJ
KCLB; 40202
NCBI_Iran; C563
RCB; RCB1189
RCB; RCB3686
TKG; TKG 0267
Ubigene; YC-D011
Cell line databases/resources CLO; CLO_0009348
CLO; CLO_0050999
MCCL; MCC:0000461
CLDB; cl4513
CLDB; cl4514
CLDB; cl4515
CLDB; cl4517
cancercelllines; CVCL_0006
CCRID; 1101HUM-PUMC000057
CCRID; 1102HUM-NIFDC00058
CCRID; 3101HUMSCSP567
CCRID; 3101HUMTCHu57
CCRID; 4201HUM-CCTCC00100
Cell_Model_Passport; SIDM01172
Cosmic-CLP; 909771
DepMap; ACH-000146
DSMZCellDive; ACC-16
IGRhCellID; THP1
LINCS_HMS; 50861
LINCS_LDP; LCL-1072
Lonza; 134
Anatomy/cell type resources BTO; BTO_0001370
Biological sample resources BioSample; SAMN03470795
BioSample; SAMN03473256
BioSample; SAMN03473419
BioSample; SAMN10987847
ENCODE; ENCBS248PAQ
ENCODE; ENCBS443IYN
ENCODE; ENCBS461BPB
ENCODE; ENCBS615XLU
ENCODE; ENCBS913QYS
ENCODE; ENCBS980LBL
CRISP screens repositories BioGRID_ORCS_Cell_line; 220
Chemistry resources ChEMBL-Cells; CHEMBL3307574
ChEMBL-Targets; CHEMBL614245
GDSC; 909771
PharmacoDB; THP1_1593_2019
PubChem_Cell_line; CVCL_0006
Encyclopedic resources Wikidata; Q7670282
Experimental variables resources EFO; EFO_0001253
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
FANTOM5_SSTAR; 10399-106A3
FANTOM5_SSTAR; 10400-106A4
FANTOM5_SSTAR; 10405-106A9
GEO; GSM236807
GEO; GSM236843
GEO; GSM482495
GEO; GSM838432
GEO; GSM838433
GEO; GSM887706
GEO; GSM888799
GEO; GSM1374962
GEO; GSM1446742
GEO; GSM1670543
GEO; GSM2141952
GEO; GSM2141956
GEO; GSM2141958
GEO; GSM2141959
GEO; GSM2141962
GEO; GSM2141968
GEO; GSM2141972
GEO; GSM2141974
GEO; GSM2141979
GEO; GSM2141986
GEO; GSM2141987
GEO; GSM2141993
GEO; GSM2141995
GEO; GSM2141998
GEO; GSM2141999
GEO; GSM2142000
GEO; GSM2142004
GEO; GSM2142005
GEO; GSM2142009
GEO; GSM2142011
GEO; GSM2142015
GEO; GSM2142016
GEO; GSM2142019
GEO; GSM2142021
GEO; GSM2142023
GEO; GSM2142024
GEO; GSM2142028
GEO; GSM2142029
GEO; GSM2142030
GEO; GSM2142031
GEO; GSM2142036
GEO; GSM2142037
GEO; GSM2142039
GEO; GSM2142048
GEO; GSM2142049
GEO; GSM2142052
GEO; GSM2142053
GEO; GSM2142055
GEO; GSM2142059
GEO; GSM2142060
GEO; GSM7701404
GEO; GSM7701405
Medical resources MeSH; D000074084
Polymorphism and mutation databases Cosmic; 717684
Cosmic; 724818
Cosmic; 787480
Cosmic; 909771
Cosmic; 919122
Cosmic; 924051
Cosmic; 947361
Cosmic; 975303
Cosmic; 991556
Cosmic; 996316
Cosmic; 998748
Cosmic; 1012124
Cosmic; 1037666
Cosmic; 1070694
Cosmic; 1078722
Cosmic; 1089517
Cosmic; 1150901
Cosmic; 1176587
Cosmic; 1181604
Cosmic; 1187864
Cosmic; 1197931
Cosmic; 1278779
Cosmic; 1281356
Cosmic; 1319551
Cosmic; 1476425
Cosmic; 1519163
Cosmic; 1524842
Cosmic; 1601064
Cosmic; 1604863
Cosmic; 2089655
Cosmic; 2131559
Cosmic; 2306241
Cosmic; 2392976
IARC_TP53; 2198
LiGeA; CCLE_181
Progenetix; CVCL_0006
Proteomic databases PRIDE; PRD000345
PRIDE; PXD000328
PRIDE; PXD000953
PRIDE; PXD004034
PRIDE; PXD008516
PRIDE; PXD011690
PRIDE; PXD015039
PRIDE; PXD030304
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update14-Aug-2025
Version number53