Cellosaurus logo
expasy logo

Cellosaurus THP-1 (CVCL_0006)

[Text version]
Cell line name THP-1
Synonyms THP1; THP 1; THPI; THP-1(ATCC); THP-1-O; O-THP-1; Tohoku Hospital Pediatrics-1
Accession CVCL_0006
Resource Identification Initiative To cite this cell line use: THP-1 (RRID:CVCL_0006)
Comments Group: Space-flown cell line (cellonaut).
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Part of: LL-100 blood cancer cell line panel.
Part of: MD Anderson Cell Lines Project.
Part of: RAS genetic alteration cell panel (ATCC TCP-1031).
Part of: Tumor Immunology Bank (TIB) collection from Salk (transferred to ATCC in 1981).
Population: Japanese.
Biotechnology: Used in the human Cell Line Activation Test (h-CLAT), an in vitro skin sensitization test (PubMed=16311011; PubMed=16337770; PubMed=29901211).
Characteristics: Can differentiate from monocytes into macrophage-like cells upon stimulation with PMA.
Virology: Not susceptible to infection by SARS coronavirus 2 (SARS-CoV-2) (COVID-19) (PubMed=33389257).
Doubling time: 60-70 hours (PubMed=6970727); 26 hours (PubMed=25984343); ~35-50 hours (DSMZ=ACC-16).
Microsatellite instability: Stable (MSS) (PubMed=10739008; PubMed=11226526; Sanger).
Omics: Deep antibody staining analysis.
Omics: Deep exome analysis.
Omics: Deep promoter analysis.
Omics: Deep quantitative proteome analysis.
Omics: DNA methylation analysis.
Omics: Glycoproteome analysis by proteomics.
Omics: HLA class I peptidome analysis by proteomics.
Omics: Protein expression by reverse-phase protein arrays.
Omics: shRNA library screening.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Anecdotal: Have been flown in space on Cosmos-2044 to study the inhibition of phorbol ester-induced cell activation in microgravity (PubMed=1915666).
Caution: NRAS mutation indicated incorrectly as being p.Gly12Ser in PubMed=9379676.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; 2457; CSNK2A1 + HGNC; 13917; DDX39B; Name(s)=CSNK2A1-DDX39B (PubMed=31160637).
  • Gene fusion; HGNC; 7132; KMT2A + HGNC; 7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (PubMed=11066077; PubMed=15843827).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (PubMed=12068308; ATCC=TIB-202; Cosmic-CLP=909771; DepMap=ACH-000146).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg174fs*3 (c.520_545del26); Zygosity=Heterozygous (PubMed=1571549; PubMed=19220422; DepMap=ACH-000146).
HLA typing Source: PubMed=22674354
Class I
HLA-AA*02
HLA-BB*15:11
HLA-CC*03
Class II
HLA-DQDQB1*05,06
HLA-DRDRB1*01,15
DRB5*01/02

Source: PubMed=26589293
Class I
HLA-AA*02:01,02:01
HLA-BB*15:11,15:11
HLA-CC*03:03,03:03

Source: CLS=300356
Class I
HLA-AA*02:01:01
HLA-BB*15:11:01
HLA-CC*03:03:01
Class II
HLA-DPDPB1*02:01:02G,04:02:01G
HLA-DQDQA1*01:01:01,01:02:01
DQB1*05:01:01,06:02:01
HLA-DRDRB1*01:01:01,15:01:01

Source: DSMZCellDive=ACC-16
Class I
HLA-AA*02:01:01,24:02:01
HLA-BB*15:11:01,35:01:01
HLA-CC*03:03:01,03:03:01
Class II
HLA-DPDPA1*01:03:01,02:02:02
DPB1*02:01:02,04:02:01
HLA-DQDQB1*05:01:01,06:02:01
HLA-DRDRA*01:01:01,01:01:01
DRB1*01:01:01,15:01:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.3
East Asian, North77.63
East Asian, South20.4
South Asian1.67
European, North0
European, South0
Disease Childhood acute monocytic leukemia (NCIt: C9163)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_5115 (A-THP-1)CVCL_B9W7 (Abcam THP-1 AATF KO)CVCL_B9W8 (Abcam THP-1 ABCB1 KO)
CVCL_B9W9 (Abcam THP-1 ABL1 KO)CVCL_B9WA (Abcam THP-1 ACVR1B KO)CVCL_B9WB (Abcam THP-1 ADGRG1 KO)
CVCL_D2N2 (Abcam THP-1 AGER KO)CVCL_B9WC (Abcam THP-1 AGTR1 KO)CVCL_B9WD (Abcam THP-1 AHR KO)
CVCL_B9WE (Abcam THP-1 AIM2 KO)CVCL_D2N3 (Abcam THP-1 AKR1B1 KO)CVCL_B9WF (Abcam THP-1 ALCAM KO)
CVCL_B9WG (Abcam THP-1 ALKBH1 KO)CVCL_B9WH (Abcam THP-1 ALYREF KO)CVCL_B1A1 (Abcam THP-1 ANPEP KO)
CVCL_D2N4 (Abcam THP-1 ANXA2 KO)CVCL_D2N5 (Abcam THP-1 ANXA5 KO)CVCL_C7EI (Abcam THP-1 APAF1 KO)
CVCL_B9WI (Abcam THP-1 APOBEC3B KO)CVCL_B9WJ (Abcam THP-1 ASAH1 KO)CVCL_B9WK (Abcam THP-1 ATF5 KO)
CVCL_B1A2 (Abcam THP-1 ATG12 KO)CVCL_B1A3 (Abcam THP-1 ATG14 KO)CVCL_B1A4 (Abcam THP-1 ATG16L1 KO)
CVCL_B9WL (Abcam THP-1 ATG3 KO)CVCL_B1A5 (Abcam THP-1 ATG5 KO)CVCL_B1A6 (Abcam THP-1 ATG7 KO)
CVCL_B9WM (Abcam THP-1 ATG9A KO)CVCL_B9WN (Abcam THP-1 BAK1 KO)CVCL_B1A7 (Abcam THP-1 BCL2 KO)
CVCL_B9WP (Abcam THP-1 BMPR2 KO)CVCL_B9WQ (Abcam THP-1 BRD1 KO)CVCL_B9WR (Abcam THP-1 BRD2 KO)
CVCL_B9WS (Abcam THP-1 BRD9 KO)CVCL_B9WT (Abcam THP-1 BTG1 KO)CVCL_B9WU (Abcam THP-1 BTK KO)
CVCL_B9WV (Abcam THP-1 BTRC KO)CVCL_B9WW (Abcam THP-1 C3 KO)CVCL_B1A8 (Abcam THP-1 CASP1 KO)
CVCL_B9WX (Abcam THP-1 CASP3 KO)CVCL_C7EJ (Abcam THP-1 CASP4 KO)CVCL_B1A9 (Abcam THP-1 CASP9 KO)
CVCL_D2N6 (Abcam THP-1 CAST KO)CVCL_B1AA (Abcam THP-1 CCL3 KO)CVCL_B9WY (Abcam THP-1 CCL4 KO)
CVCL_B9WZ (Abcam THP-1 CCR2 KO)CVCL_B9X0 (Abcam THP-1 CCRL2 KO)CVCL_B9X1 (Abcam THP-1 CCL22 KO)
CVCL_B9X2 (Abcam THP-1 CD36 KO)CVCL_D2N7 (Abcam THP-1 CD46 KO)CVCL_B9X3 (Abcam THP-1 CD48 KO)
CVCL_B9X4 (Abcam THP-1 CD58 KO)CVCL_B9X5 (Abcam THP-1 CD59 KO)CVCL_B9X6 (Abcam THP-1 CD81 KO)
CVCL_D2N8 (Abcam THP-1 CES1 KO)CVCL_B1AB (Abcam THP-1 CHI3L1 KO)CVCL_B9X7 (Abcam THP-1 CITED2 KO)
CVCL_B9X8 (Abcam THP-1 CLU KO)CVCL_B9X9 (Abcam THP-1 CMKLR1 KO)CVCL_B9XA (Abcam THP-1 CMTM6 KO)
CVCL_B9XB (Abcam THP-1 CNR2 KO)CVCL_B9XC (Abcam THP-1 CST3 KO)CVCL_B9XD (Abcam THP-1 CTSB KO)
CVCL_D2N9 (Abcam THP-1 CTSG KO)CVCL_B9XE (Abcam THP-1 CTSS KO)CVCL_B9XF (Abcam THP-1 CUL2 KO)
CVCL_B9XG (Abcam THP-1 CUL3 KO)CVCL_D2NA (Abcam THP-1 CUL4A KO)CVCL_B9XH (Abcam THP-1 CUL4B KO)
CVCL_B9XI (Abcam THP-1 CX3CR1 KO)CVCL_B1AC (Abcam THP-1 CXCL10 KO)CVCL_B1AD (Abcam THP-1 CXCR2 KO)
CVCL_B9XJ (Abcam THP-1 CXXC1 KO)CVCL_D2NB (Abcam THP-1 DCK KO)CVCL_B9XK (Abcam THP-1 DCP2 KO)
CVCL_B9XL (Abcam THP-1 DLL1 KO)CVCL_B9XM (Abcam THP-1 DVL3 KO)CVCL_B9XN (Abcam THP-1 EGLN1 KO)
CVCL_B9XP (Abcam THP-1 EHMT2 KO)CVCL_B9XQ (Abcam THP-1 EIF2AK4 KO)CVCL_B9XR (Abcam THP-1 ENG KO)
CVCL_B9XS (Abcam THP-1 EPHB4 KO)CVCL_B9XT (Abcam THP-1 ERAP1 KO)CVCL_B9XU (Abcam THP-1 ETS2 KO)
CVCL_B9XV (Abcam THP-1 EXO1 KO)CVCL_D2NC (Abcam THP-1 EZH2 KO)CVCL_B9XW (Abcam THP-1 FABP4 KO)
CVCL_D5HB (Abcam THP-1 FCER1G KO)CVCL_B9XX (Abcam THP-1 FCGR1A KO)CVCL_D2ND (Abcam THP-1 FDFT1 KO)
CVCL_B9XY (Abcam THP-1 FGF23 KO)CVCL_B9XZ (Abcam THP-1 FKBP5 KO)CVCL_B9Y0 (Abcam THP-1 FOXO1 KO)
CVCL_B9Y1 (Abcam THP-1 FOXO3 KO)CVCL_B9Y2 (Abcam THP-1 FST KO)CVCL_B9Y3 (Abcam THP-1 FTL KO)
CVCL_B9Y4 (Abcam THP-1 FZD7 KO)CVCL_B9Y5 (Abcam THP-1 GAB1 KO)CVCL_D2NE (Abcam THP-1 GCLM KO)
CVCL_D2NF (Abcam THP-1 GGT1 KO)CVCL_D2NG (Abcam THP-1 GHR KO)CVCL_B9Y6 (Abcam THP-1 GLB1 KO)
CVCL_B9Y7 (Abcam THP-1 GPR132 KO)CVCL_D2NH (Abcam THP-1 GSTP1 KO)CVCL_B9Y8 (Abcam THP-1 GZMA KO)
CVCL_B9Y9 (Abcam THP-1 HLA-B KO)CVCL_D2NI (Abcam THP-1 HMMR KO)CVCL_B9YA (Abcam THP-1 HNF1B KO)
CVCL_B9YB (Abcam THP-1 HSPG2 KO)CVCL_B9YC (Abcam THP-1 ID2 KO)CVCL_B9YD (Abcam THP-1 IL17RB KO)
CVCL_B1AE (Abcam THP-1 IL1B KO)CVCL_B9YE (Abcam THP-1 IRAK3 KO)CVCL_D2NJ (Abcam THP-1 ITGA5 KO)
CVCL_B9YF (Abcam THP-1 ITPR3 KO)CVCL_B9YG (Abcam THP-1 JAG1 KO)CVCL_D2NK (Abcam THP-1 JAK2 KO)
CVCL_B9YH (Abcam THP-1 JMJD6 KO)CVCL_B9YI (Abcam THP-1 KAT7 KO)CVCL_B9YJ (Abcam THP-1 KDM1B KO)
CVCL_B9YK (Abcam THP-1 KDM6B KO)CVCL_B9YL (Abcam THP-1 KPNA2 KO)CVCL_B9YM (Abcam THP-1 LAIR1 KO)
CVCL_B9YN (Abcam THP-1 LAMP2 KO)CVCL_B1AF (Abcam THP-1 LATS1 KO)CVCL_B9YP (Abcam THP-1 LDHA KO)
CVCL_B1AG (Abcam THP-1 LGALS9 KO)CVCL_D2NL (Abcam THP-1 LGMN KO)CVCL_B9YQ (Abcam THP-1 LGR6 KO)
CVCL_B9YR (Abcam THP-1 LMNB1 KO)CVCL_D2NM (Abcam THP-1 LOX KO)CVCL_B1AH (Abcam THP-1 LYZ KO)
CVCL_B9YS (Abcam THP-1 MACROH2A1 KO)CVCL_C7EK (Abcam THP-1 MAD1L1 KO)CVCL_B9YT (Abcam THP-1 MAGEA3 KO)
CVCL_B9YU (Abcam THP-1 MAP2K3 KO)CVCL_B9YV (Abcam THP-1 MAP3K3 KO)CVCL_B9YW (Abcam THP-1 MAPK7 KO)
CVCL_D2NN (Abcam THP-1 MARCKS KO)CVCL_B9YX (Abcam THP-1 MBD1 KO)CVCL_B9YY (Abcam THP-1 MBD3 KO)
CVCL_D2NP (Abcam THP-1 MBNL1 KO)CVCL_B9YZ (Abcam THP-1 MME KO)CVCL_B9Z0 (Abcam THP-1 MMP13 KO)
CVCL_C7EL (Abcam THP-1 MMP3 KO)CVCL_B9Z1 (Abcam THP-1 MMP8 KO)CVCL_B9Z2 (Abcam THP-1 MTA3 KO)
CVCL_D2NQ (Abcam THP-1 NAMPT KO)CVCL_B9Z3 (Abcam THP-1 NBR1 KO)CVCL_B9Z4 (Abcam THP-1 NCR3LG1 KO)
CVCL_B9Z5 (Abcam THP-1 NFKB1 KO)CVCL_B9Z6 (Abcam THP-1 NLRC4 KO)CVCL_B9Z7 (Abcam THP-1 NLRP3 KO)
CVCL_B9Z8 (Abcam THP-1 NOTCH3 KO)CVCL_B9Z9 (Abcam THP-1 NOTCH4 KO)CVCL_B9ZA (Abcam THP-1 NQO1 KO)
CVCL_B9ZB (Abcam THP-1 NR1H4 KO)CVCL_B9ZC (Abcam THP-1 NR3C2 KO)CVCL_D2NR (Abcam THP-1 ODC1 KO)
CVCL_D2NS (Abcam THP-1 P2RX7 KO)CVCL_D2NT (Abcam THP-1 P2RY12 KO)CVCL_B9ZD (Abcam THP-1 PDCD1LG2 KO)
CVCL_D2NU (Abcam THP-1 PDIA3 KO)CVCL_D2NV (Abcam THP-1 PGK1 KO)CVCL_B9ZE (Abcam THP-1 PHF8 KO)
CVCL_D2NW (Abcam THP-1 PHGDH KO)CVCL_B9ZF (Abcam THP-1 PIK3CA KO)CVCL_B9ZG (Abcam THP-1 PIK3CD KO)
CVCL_B9ZH (Abcam THP-1 PIK3R4 KO)CVCL_B9ZI (Abcam THP-1 PLA2G4A KO)CVCL_B9ZJ (Abcam THP-1 PLAU KO)
CVCL_D2NX (Abcam THP-1 PLAUR KO)CVCL_B9ZK (Abcam THP-1 PLCB3 KO)CVCL_B9ZL (Abcam THP-1 PLCG1 KO)
CVCL_D2NY (Abcam THP-1 POU2F1 KO)CVCL_D1YJ (Abcam THP-1 PRDX6 KO)CVCL_B9ZM (Abcam THP-1 PRMT7 KO)
CVCL_B9ZN (Abcam THP-1 PSEN1 KO)CVCL_C7EM (Abcam THP-1 PSMB9 KO)CVCL_B9ZP (Abcam THP-1 PTGER4 KO)
CVCL_B9ZQ (Abcam THP-1 PTGES2 KO)CVCL_B9ZR (Abcam THP-1 PTK2 KO)CVCL_D2NZ (Abcam THP-1 PTK2B KO)
CVCL_B9ZS (Abcam THP-1 PTP4A3 KO)CVCL_B9ZT (Abcam THP-1 PTPN12 KO)CVCL_B1AI (Abcam THP-1 PTPN6 KO)
CVCL_B9ZU (Abcam THP-1 PUS1 KO)CVCL_D2P0 (Abcam THP-1 RAB5A KO)CVCL_B9ZV (Abcam THP-1 RAC2 KO)
CVCL_C7EN (Abcam THP-1 RBL2 KO)CVCL_D2P1 (Abcam THP-1 RETN KO)CVCL_B9ZW (Abcam THP-1 RING1 KO)
CVCL_B1AJ (Abcam THP-1 RIPK1 KO)CVCL_C7EP (Abcam THP-1 ROCK1 KO)CVCL_B9ZX (Abcam THP-1 ROCK2 KO)
CVCL_B9ZY (Abcam THP-1 ROR2 KO)CVCL_B9ZZ (Abcam THP-1 RUNX2 KO)CVCL_C0A0 (Abcam THP-1 RYBP KO)
CVCL_D2P2 (Abcam THP-1 RYR1 KO)CVCL_C0A1 (Abcam THP-1 S100A8 KO)CVCL_D2P3 (Abcam THP-1 SATB1 KO)
CVCL_C0A2 (Abcam THP-1 SCARB1 KO)CVCL_C0A3 (Abcam THP-1 SDC4 KO)CVCL_C0A4 (Abcam THP-1 SETD2 KO)
CVCL_C7EQ (Abcam THP-1 SKP2 KO)CVCL_D2P4 (Abcam THP-1 SLC12A5 KO)CVCL_D2P5 (Abcam THP-1 SLC16A1 KO)
CVCL_D2P6 (Abcam THP-1 SLC29A1 KO)CVCL_D2P7 (Abcam THP-1 SLC9A1 KO)CVCL_C0A5 (Abcam THP-1 SLFN11 KO)
CVCL_C0A6 (Abcam THP-1 SMARCAL1 KO)CVCL_C0A7 (Abcam THP-1 SMARCC2 KO)CVCL_C0A8 (Abcam THP-1 SMARCE1 KO)
CVCL_C7ER (Abcam THP-1 SMPD1 KO)CVCL_C0A9 (Abcam THP-1 SMURF1 KO)CVCL_C0AA (Abcam THP-1 SMYD2 KO)
CVCL_C0AB (Abcam THP-1 SMYD3 KO)CVCL_C0AC (Abcam THP-1 SOCS3 KO)CVCL_D2P8 (Abcam THP-1 SPHK1 KO)
CVCL_C0AD (Abcam THP-1 SRF KO)CVCL_C0AE (Abcam THP-1 SRPK1 KO)CVCL_C0AF (Abcam THP-1 STAT4 KO)
CVCL_C0AG (Abcam THP-1 STAT5A KO)CVCL_D2P9 (Abcam THP-1 STIM2 KO)CVCL_B1AK (Abcam THP-1 STING1 KO)
CVCL_D2PA (Abcam THP-1 STIP1 KO)CVCL_C0AH (Abcam THP-1 STK4 KO)CVCL_C0AI (Abcam THP-1 SUV39H1 KO)
CVCL_C0AJ (Abcam THP-1 SUZ12 KO)CVCL_C0AK (Abcam THP-1 TAPBP KO)CVCL_C0AL (Abcam THP-1 TBK1 KO)
CVCL_C0AM (Abcam THP-1 TBP KO)CVCL_C0AN (Abcam THP-1 TCF7L2 KO)CVCL_C0AP (Abcam THP-1 TFDP1 KO)
CVCL_C0AQ (Abcam THP-1 THBS1 KO)CVCL_C7ES (Abcam THP-1 TIMP2 KO)CVCL_C0AR (Abcam THP-1 TIMP3 KO)
CVCL_C0AS (Abcam THP-1 TLN1 KO)CVCL_B1AL (Abcam THP-1 TNF KO)CVCL_C0AT (Abcam THP-1 TNFRSF10B KO)
CVCL_C0AU (Abcam THP-1 TNFRSF1B KO)CVCL_C0AV (Abcam THP-1 TP73 KO)CVCL_D2PB (Abcam THP-1 TPM1 KO)
CVCL_C0AW (Abcam THP-1 TRADD KO)CVCL_C0AX (Abcam THP-1 TRAF2 KO)CVCL_C7ET (Abcam THP-1 TRAP1 KO)
CVCL_B1AM (Abcam THP-1 TREM2 KO)CVCL_C0AY (Abcam THP-1 TRMT2A KO)CVCL_D2PC (Abcam THP-1 TUBA4A KO)
CVCL_C0AZ (Abcam THP-1 TWIST1 KO)CVCL_C0B0 (Abcam THP-1 TWIST2 KO)CVCL_C7EU (Abcam THP-1 TXNRD1 KO)
CVCL_C7EV (Abcam THP-1 TXNIP KO)CVCL_D2PD (Abcam THP-1 TYMS KO)CVCL_B7TG (Abcam THP-1 TYROBP KO)
CVCL_C0B1 (Abcam THP-1 U2AF1 KO)CVCL_C0B2 (Abcam THP-1 UBA1 KO)CVCL_C0B3 (Abcam THP-1 UBE2D2 KO)
CVCL_C0B4 (Abcam THP-1 UCHL5 KO)CVCL_D2PE (Abcam THP-1 UCP2 KO)CVCL_C0B5 (Abcam THP-1 ULBP2 KO)
CVCL_C0B6 (Abcam THP-1 ULBP3 KO)CVCL_C0B7 (Abcam THP-1 UVRAG KO)CVCL_C0B8 (Abcam THP-1 VAV1 KO)
CVCL_C0B9 (Abcam THP-1 VCAN KO)CVCL_C0BA (Abcam THP-1 WDR77 KO)CVCL_C0BB (Abcam THP-1 WNT11 KO)
CVCL_D2PF (Abcam THP-1 XBP1 KO)CVCL_D2PG (Abcam THP-1 XDH KO)CVCL_C0BC (Abcam THP-1 YTHDC2 KO)
CVCL_C0BD (Abcam THP-1 YTHDF1 KO)CVCL_C0BE (Abcam THP-1 YTHDF3 KO)CVCL_C0BF (Abcam THP-1 YY1 KO)
CVCL_C0BG (Abcam THP-1 ZEB2 KO)CVCL_X687 (BF24)CVCL_KB46 (CellSensor NFkB-bla THP-1)
CVCL_KS29 (CellSensor SIE-bla THP-1)CVCL_KS30 (CellSensor TNFalpha-bla THP-1)CVCL_E2QA (HyCyte THP-1 hADAP1_p.P14R_c.41C>G)
CVCL_E2QB (HyCyte THP-1 hKDM6A_p.A694T_c.2080G>A)CVCL_D6CN (HyCyte THP-1 KO-hCASP1)CVCL_D6CP (HyCyte THP-1 KO-hCD274)
CVCL_D6CQ (HyCyte THP-1 KO-hCD44)CVCL_E1MY (HyCyte THP-1 KO-hELF4)CVCL_E1MZ (HyCyte THP-1 KO-hGSDMD)
CVCL_E1N0 (HyCyte THP-1 KO-hHNRNPA2B1)CVCL_E1N1 (HyCyte THP-1 KO-hIRAK4)CVCL_E1N2 (HyCyte THP-1 KO-hLAMTOR2)
CVCL_E1N3 (HyCyte THP-1 KO-hMCFD2)CVCL_E1N4 (HyCyte THP-1 KO-hNCF1)CVCL_E1N5 (HyCyte THP-1 KO-hOSM)
CVCL_E1N6 (HyCyte THP-1 KO-hSETDB2)CVCL_E1N7 (HyCyte THP-1 KO-hSMAD3)CVCL_D6CR (HyCyte THP-1 KO-hTHRAP3)
CVCL_D6CS (HyCyte THP-1 KO-hTNF)CVCL_D6CT (HyCyte THP-1 KO-hUSP10)CVCL_KZ70 (PathHunter THP-1 IkappaB Degradation)
CVCL_IR08 (PSC-THP1)CVCL_A4CA (THP-1 AP1-Luc2)CVCL_A4CB (THP-1 CRE-Luc2)
CVCL_A4CD (THP-1 GAS-Luc2)CVCL_A4CC (THP-1 ISRE-Luc2)CVCL_XZ65 (THP-1 NF-kb luciferase reporter)
CVCL_A4CE (THP-1 NF-kB-Luc2)CVCL_B5NS (THP-1 NFAT-Luc2)CVCL_E2QQ (THP-1 NF-kappaB-eGFP)
CVCL_DF52 (THP-1 NucLight Red)CVCL_C3EW (THP-1 Safe Harbor Landing Pad)CVCL_XI47 (THP-1 TLR9 mCherry)
CVCL_C8WG (THP-1-EGFP)CVCL_C8WH (THP-1-Luc)CVCL_0R25 (THP-1(NCI))
CVCL_C0YT (THP-1-Cs5)CVCL_C0YQ (THP-1-R)CVCL_WI26 (THP-1/AR)
CVCL_4V22 (THP-1/ara-C)CVCL_0R21 (THP-1/DC-SIGN)CVCL_A1RT (THP-1/E)
CVCL_XD94 (THP-1/IL15)CVCL_XD95 (THP-1/IL21)CVCL_3426 (THP-1h)
CVCL_3427 (THP-1l)CVCL_D5JL (THP-G1b)CVCL_D5JK (THP-G8)
CVCL_C0QX (THP1 GFP-PEAK3)CVCL_C0QY (THP1 ST-PEAK3)CVCL_A8AT (THP1-ASC-GFP)
CVCL_X588 (THP1-Blue ISG)CVCL_X589 (THP1-Blue ISG-KD-STING)CVCL_X585 (THP1-Blue NF-kappaB)
CVCL_X599 (THP1-Dual)CVCL_A8BE (THP1-HMGB1-Lucia)CVCL_X587 (THP1-Lucia ISG)
CVCL_X590 (THP1-Lucia NF-kappaB)CVCL_5I77 (THP1-NLRC4)CVCL_X601 (THP1-Null)
CVCL_A8AK (THP1-Null2)CVCL_X582 (THP1-Xblue)CVCL_A0HA (THP18)
CVCL_E1CM (Ubigene THP-1 ACOD1 KO)CVCL_E1CN (Ubigene THP-1 ADA2 KO)CVCL_E1CP (Ubigene THP-1 AHR KO)
CVCL_E1CQ (Ubigene THP-1 C15orf48 KO)CVCL_E1CR (Ubigene THP-1 CARD8 KO)CVCL_E1CS (Ubigene THP-1 CES1 KO)
CVCL_E1CT (Ubigene THP-1 CLEC10A KO)CVCL_E1CU (Ubigene THP-1 CLEC4A KO)CVCL_E1CV (Ubigene THP-1 EGR1 KO)
CVCL_E1CW (Ubigene THP-1 GLP1R KO)CVCL_E1CX (Ubigene THP-1 GPNMB KO)CVCL_E1CY (Ubigene THP-1 GSDMD KO)
CVCL_E1CZ (Ubigene THP-1 HERC5 KO)CVCL_E1D0 (Ubigene THP-1 IFI35 KO)CVCL_E1D1 (Ubigene THP-1 ISG15 KO)
CVCL_E1D2 (Ubigene THP-1 MCU KO)CVCL_E1D3 (Ubigene THP-1 MILR1 KO)CVCL_E1D4 (Ubigene THP-1 NFE2L2 KO)
CVCL_E1D5 (Ubigene THP-1 NLRP3 KO)CVCL_E1D6 (Ubigene THP-1 NMI KO)CVCL_E1D7 (Ubigene THP-1 PIGA KO)
CVCL_E1D8 (Ubigene THP-1 PTPN11 KO)CVCL_E1D9 (Ubigene THP-1 RNASE1 KO)CVCL_E1DA (Ubigene THP-1 SIGLEC9 KO)
CVCL_E1DB (Ubigene THP-1 SLAMF7 KO)CVCL_E1DC (Ubigene THP-1 SLC37A4 KO)CVCL_E1DD (Ubigene THP-1 SLC39A8 KO)
CVCL_E1DE (Ubigene THP-1 SLC6A6 KO)CVCL_E1DF (Ubigene THP-1 TCN2 KO)CVCL_E1DG (Ubigene THP-1 TET2 KO)
CVCL_E1DH (Ubigene THP-1 TLR1 KO)CVCL_E1DI (Ubigene THP-1 TLR2 KO)CVCL_E1DJ (Ubigene THP-1 TLR4 KO)
CVCL_E1DK (Ubigene THP-1 TREM2 KO)CVCL_E1DL (Ubigene THP-1 UBA7 KO)CVCL_E1DM (Ubigene THP-1 USP22 KO)
CVCL_E1DN (Ubigene THP-1 VAMP2 KO)CVCL_E1DP (Ubigene THP-1 ZEB1 KO)
Sex of cell Male
Age at sampling 1Y
Category Cancer cell line
STR profile Source(s): AddexBio=C0003024/4956; ATCC=TIB-202; CCRID; CLS=300356; Cosmic-CLP=909771; DSMZ=ACC-16; ECACC=88081201; ICLC=HTL97014; JCRB=JCRB0112; JCRB=JCRB0112.1; KCLB=40202; PubMed=11416159; PubMed=25877200; PubMed=35373342; RCB=RCB1189; Technion Genomics Center; TKG=TKG 0267

Markers:
AmelogeninX,Y
CSF1PO11,13
D1S165616,17
D2S44110,11
D2S133817,18
D3S135815,17
D5S81811,12
D7S82010
D8S117910,14
D10S124814
D12S39118,19
D13S3178,13 (CCRID; DSMZ=ACC-16; JCRB=JCRB0112; RCB=RCB1189; TKG=TKG 0267)
13 (AddexBio=C0003024/4956; ATCC=TIB-202; CLS=300356; Cosmic-CLP=909771; ECACC=88081201; JCRB=JCRB0112.1; KCLB=40202; PubMed=25877200; Technion Genomics Center)
D16S53911,12
D18S5113,14
D19S43312.2,13 (ATCC=TIB-202; Technion Genomics Center)
12.2,13,14 (CCRID)
13 (DSMZ=ACC-16)
D21S1130,31.2
D22S104511,15
DYS39110
FGA24,25
Penta D10,12
Penta E11,15
TH018,9.3
TPOX8,11
vWA16 (AddexBio=C0003024/4956; ATCC=TIB-202; CCRID; CLS=300356; Cosmic-CLP=909771; ECACC=88081201; ICLC=HTL97014; JCRB=JCRB0112.1; KCLB=40202; PubMed=11416159; PubMed=25877200; Technion Genomics Center)
16,17 (DSMZ=ACC-16; JCRB=JCRB0112; RCB=RCB1189; TKG=TKG 0267)

Run an STR similarity search on this cell line
Web pages https://en.wikipedia.org/wiki/THP-1_cell_line
https://www.proteinatlas.org/learn/cellines
https://strap.nci.nih.gov/celline_detail.php?sample_id=78
http://www.bowdish.ca/lab/wp-content/uploads/2011/07/THP-1-propagation-culture.pdf
https://web.archive.org/web/20201109215324/www.infarktforschung.de/macrophages_cell_lines.html
https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/t/cell-lines-detail-444.html
https://tcpaportal.org/mclp/
https://read.oecd-ilibrary.org/environment/test-no-442e-in-vitro-skin-sensitisation_9789264264359-en
Publications

PubMed=6970727; DOI=10.1002/ijc.2910260208
Tsuchiya S., Yamabe M., Yamaguchi Y., Kobayashi Y., Konno T., Tada K.
Establishment and characterization of a human acute monocytic leukemia cell line (THP-1).
Int. J. Cancer 26:171-176(1980)

PubMed=6949641
Tsuchiya S., Kobayashi Y., Goto Y., Okumura H., Nakae S., Konno T., Tada K.
Induction of maturation in cultured human monocytic leukemia cells by a phorbol diester.
Cancer Res. 42:1530-1536(1982)

PubMed=6091813; DOI=10.1182/blood.V64.5.1059.1059
Palumbo A., Minowada J., Erikson J., Croce C.M., Rovera G.
Lineage infidelity of a human myelogenous leukemia cell line.
Blood 64:1059-1063(1984)

PubMed=2985879; DOI=10.1016/0145-2126(85)90084-0
Drexler H.G., Gaedicke G., Minowada J.
Isoenzyme studies in human leukemia-lymphoma cell lines -- 1 carboxylic esterase.
Leuk. Res. 9:209-229(1985)

PubMed=3159941; DOI=10.1016/0145-2126(85)90134-1
Drexler H.G., Gaedicke G., Minowada J.
Isoenzyme studies in human leukemia-lymphoma cell lines -- III Beta-hexosaminidase (E.C. 3.2.1.30).
Leuk. Res. 9:549-559(1985)

PubMed=3874327; DOI=10.1016/0145-2126(85)90133-x
Drexler H.G., Gaedicke G., Minowada J.
Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid phosphatase.
Leuk. Res. 9:537-548(1985)

PubMed=2633408; DOI=10.1620/tjem.159.299
Saijo Y., Kumano N., Tokue Y., Satoh K., Oizumi K., Motomiya M.
Characterization of resistance to VP-16 in human leukemic cell line.
Tohoku J. Exp. Med. 159:299-306(1989)

PubMed=1915666; DOI=10.1016/0014-4827(91)90482-A
Limouse M., Manie S., Konstantinova I., Ferrua B., Schaffar L.
Inhibition of phorbol ester-induced cell activation in microgravity.
Exp. Cell Res. 197:82-86(1991)

PubMed=1571549; DOI=10.1182/blood.V79.9.2378.2378
Sugimoto K., Toyoshima H., Sakai R., Miyagawa K., Hagiwara K., Ishikawa F., Takaku F., Yazaki Y., Hirai H.
Frequent mutations in the p53 gene in human myeloid leukemia cell lines.
Blood 79:2378-2383(1992)

PubMed=8558913
Morita S., Tsuchiya S., Fujie H., Itano M., Ohashi Y., Minegishi M., Imaizumi M., Endo M., Takano N., Konno T.
Cell surface c-kit receptors in human leukemia cell lines and pediatric leukemia: selective preservation of c-kit expression on megakaryoblastic cell lines during adaptation to in vitro culture.
Leukemia 10:102-105(1996)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=9379676; DOI=10.1016/S0145-2126(97)00036-2
Sheng X.-M., Kawamura M., Ohnishi H., Ida K., Hanada R., Kojima S., Kobayashi M., Bessho F., Yanagisawa M., Hayashi Y.
Mutations of the RAS genes in childhood acute myeloid leukemia, myelodysplastic syndrome and juvenile chronic myelocytic leukemia.
Leuk. Res. 21:697-701(1997)

PubMed=9510473; DOI=10.1111/j.1349-7006.1998.tb00476.x; PMCID=PMC5921588
Hosoya N., Hangaishi A., Ogawa S., Miyagawa K., Mitani K., Yazaki Y., Hirai H.
Frameshift mutations of the hMSH6 gene in human leukemia cell lines.
Jpn. J. Cancer Res. 89:33-39(1998)

PubMed=9738977; DOI=10.1111/j.1349-7006.1998.tb03275.x; PMCID=PMC5921886
Takizawa J., Suzuki R., Kuroda H., Utsunomiya A., Kagami Y., Joh T., Aizawa Y., Ueda R., Seto M.
Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia.
Jpn. J. Cancer Res. 89:712-718(1998)

PubMed=10223614; DOI=10.1620/tjem.186.99
Tominaga T., Suzuki M., Saeki H., Matsuno S., Tachibana T., Kudo T.
Establishment of an activated macrophage cell line, A-THP-1, and its properties.
Tohoku J. Exp. Med. 186:99-119(1998)

PubMed=10739008; DOI=10.1016/S0145-2126(99)00182-4
Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.
Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines.
Leuk. Res. 24:255-262(2000)

PubMed=11066077; DOI=10.1002/1098-2264(2000)9999:9999<::AID-GCC1040>3.0.CO;2-Z
Odero M.D., Zeleznik-Le N.J., Chinwalla V., Rowley J.D.
Cytogenetic and molecular analysis of the acute monocytic leukemia cell line THP-1 with an MLL-AF9 translocation.
Genes Chromosomes Cancer 29:333-338(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=11226526; DOI=10.1016/S0145-2126(00)00121-1
Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.
Corrigendum to: Frequent microsatellite instability and BAX mutations in T cell acute lymphoblastic leukemia cell lines Leukemia Research 24 (2000), 255-262.
Leuk. Res. 25:275-278(2001)

PubMed=11414198; DOI=10.1007/s004320000207
Lahm H., Andre S., Hoeflich A., Fischer J.R., Sordat B., Kaltner H., Wolf E., Gabius H.-J.
Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures.
J. Cancer Res. Clin. Oncol. 127:375-386(2001)

PubMed=11416159; DOI=10.1073/pnas.121616198; PMCID=PMC35459
Masters J.R.W., Thomson J.A., Daly-Burns B., Reid Y.A., Dirks W.G., Packer P., Toji L.H., Ohno T., Tanabe H., Arlett C.F., Kelland L.R., Harrison M., Virmani A.K., Ward T.H., Ayres K.L., Debenham P.G.
Short tandem repeat profiling provides an international reference standard for human cell lines.
Proc. Natl. Acad. Sci. U.S.A. 98:8012-8017(2001)

PubMed=12068308; DOI=10.1038/nature00766
Davies H.R., Bignell G.R., Cox C., Stephens P.J., Edkins S., Clegg S., Teague J.W., Woffendin H., Garnett M.J., Bottomley W., Davis N., Dicks E., Ewing R., Floyd Y., Gray K., Hall S., Hawes R., Hughes J., Kosmidou V., Menzies A., Mould C., Parker A., Stevens C., Watt S., Hooper S., Wilson R., Jayatilake H., Gusterson B.A., Cooper C.S., Shipley J.M., Hargrave D., Pritchard-Jones K., Maitland N.J., Chenevix-Trench G., Riggins G.J., Bigner D.D., Palmieri G., Cossu A., Flanagan A.M., Nicholson A., Ho J.W.C., Leung S.Y., Yuen S.T., Weber B.L., Seigler H.F., Darrow T.L., Paterson H.F., Marais R., Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.
Mutations of the BRAF gene in human cancer.
Nature 417:949-954(2002)

PubMed=14504097; DOI=10.1182/blood-2003-02-0418
Taketani T., Taki T., Sugita K., Furuichi Y., Ishii E., Hanada R., Tsuchida M., Sugita K., Ida K., Hayashi Y.
FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy.
Blood 103:1085-1088(2004)

PubMed=14671638; DOI=10.1038/sj.leu.2403236
Drexler H.G., Quentmeier H., MacLeod R.A.F.
Malignant hematopoietic cell lines: in vitro models for the study of MLL gene alterations.
Leukemia 18:227-232(2004)

PubMed=15843827; DOI=10.1038/sj.leu.2403749
Andersson A., Eden P., Lindgren D., Nilsson J., Lassen C., Heldrup J., Fontes M., Borg A., Mitelman F., Johansson B., Hoglund M., Fioretos T.
Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.
Leukemia 19:1042-1050(2005)

PubMed=16311011; DOI=10.1016/j.tiv.2005.10.012
Ashikaga T., Yoshida Y., Hirota M., Yoneyama K., Itagaki H., Sakaguchi H., Miyazawa M., Ito Y., Suzuki H., Toyoda H.
Development of an in vitro skin sensitization test using human cell lines: the human Cell Line Activation Test (h-CLAT). I. Optimization of the h-CLAT protocol.
Toxicol. In Vitro 20:767-773(2006)

PubMed=16337770; DOI=10.1016/j.tiv.2005.10.014
Sakaguchi H., Ashikaga T., Miyazawa M., Yoshida Y., Ito Y., Yoneyama K., Hirota M., Itagaki H., Toyoda H., Suzuki H.
Development of an in vitro skin sensitization test using human cell lines; human Cell Line Activation Test (h-CLAT). II. An inter-laboratory study of the h-CLAT.
Toxicol. In Vitro 20:774-784(2006)

PubMed=16408098; DOI=10.1038/sj.leu.2404081
Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
Leukemia 20:471-476(2006)

PubMed=19220422; DOI=10.1111/j.1600-0609.2009.01211.x
Kamihira S., Terada C., Sasaki D., Yanagihara K., Tsukasaki K., Hasegawa H., Yamada Y.
Aberrant p53 protein expression and function in a panel of hematopoietic cell lines with different p53 mutations.
Eur. J. Haematol. 82:301-307(2009)

PubMed=19377474; DOI=10.1038/ng.375; PMCID=PMC6711855
Suzuki H., Forrest A.R.R., van Nimwegen E., Daub C.O., Balwierz P.J., Irvine K.M., Lassmann T., Ravasi T., Hasegawa Y., de Hoon M.J.L., Katayama S., Schroder K., Carninci P., Tomaru Y., Kanamori-Katayama M., Kubosaki A., Akalin A., Ando Y., Arner E., Asada M., Asahara H., Bailey T., Bajic V.B., Bauer D., Beckhouse A.G., Bertin N., Bjorkegren J., Brombacher F., Bulger E., Chalk A.M., Chiba J., Cloonan N., Dawe A., Dostie J., Engstrom P.G., Essack M., Faulkner G.J., Fink J.L., Fredman D., Fujimori K., Furuno M., Gojobori T., Gough J., Grimmond S.M., Gustafsson M., Hashimoto M., Hashimoto T., Hatakeyama M., Heinzel S., Hide W.A., Hofmann O., Hornquist M., Huminiecki L., Ikeo K., Imamoto N., Inoue S., Inoue Y., Ishihara R., Iwayanagi T., Jacobsen A., Kaur M., Kawaji H., Kerr M.C., Kimura R., Kimura S., Kimura Y., Kitano H., Koga H., Kojima T., Kondo S., Konno T., Krogh A., Kruger A., Kumar A., Lenhard B., Lennartsson A., Lindow M., Lizio M., MacPherson C., Maeda N., Maher C.A., Maqungo M., Mar J., Matigian N.A., Matsuda H., Mattick J.S., Meier S., Miyamoto S., Miyamoto-Sato E., Nakabayashi K., Nakachi Y., Nakano M., Nygaard S., Okayama T., Okazaki Y., Okuda-Yabukami H., Orlando V., Otomo J., Pachkov M., Petrovsky N., Plessy C., Quackenbush J., Radovanovic A., Rehli M., Saito R., Sandelin A., Schmeier S., Schonbach C., Schwartz A.S., Semple C.A., Sera M., Severin J., Shirahige K., Simons C., St Laurent G., Suzuki M., Suzuki T., Sweet M.J., Taft R.J., Takeda S., Takenaka Y., Tan K., Taylor M.S., Teasdale R.D., Tegner J., Teichmann S.A., Valen E., Wahlestedt C., Waki K., Waterhouse A., Wells C.A., Winther O., Wu L., Yamaguchi K., Yanagawa H., Yasuda J., Zavolan M., Hume D.A., Arakawa T., Fukuda S., Imamura K., Kai C., Kaiho A., Kawashima T., Kawazu C., Kitazume Y., Kojima M., Miura H., Murakami K., Murata M., Ninomiya N., Nishiyori H., Noma S., Ogawa C., Sano T., Simon C., Tagami M., Takahashi Y., Kawai J., Hayashizaki Y.
FANTOM Consortium
Riken Omics Science Center
The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line.
Nat. Genet. 41:553-562(2009)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22645513; DOI=10.3389/fendo.2011.00089; PMCID=PMC3355855
Keuper M., Dzyakanchuk A., Amrein K.E., Wabitsch M., Fischer-Posovszky P.
THP-1 macrophages and SGBS adipocytes -- a new human in vitro model system of inflamed adipose tissue.
Front. Endocrinol. 2:89.1-89.8(2011)

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=22481983; DOI=10.2174/1874091X01206010016; PMCID=PMC3314867
Chauhan V., Howland M., Wilkins R.C.
Effects of alpha-particle radiation on microRNA responses in human cell-lines.
Open Biochem. J. 6:16-22(2012)

PubMed=23097634; DOI=10.1100/2012/205038; PMCID=PMC3477555
Chauhan V., Howland M.
Genomic profiling of a human leukemic monocytic cell-line (THP-1) exposed to alpha particle radiation.
ScientificWorldJournal 2012:205038.1-205038.9(2012)

PubMed=22674354; DOI=10.1002/ijc.27661
Battle R., Poole K., Haywood-Small S., Clark B., Woodroofe M.N.
Molecular characterisation of the monocytic cell line THP-1 demonstrates a discrepancy with the documented HLA type.
Int. J. Cancer 132:246-247(2013)

PubMed=23955599; DOI=10.1038/ng.2731
Kon A., Shih L.-Y., Minamino M., Sanada M., Shiraishi Y., Nagata Y., Yoshida K.-i., Okuno Y., Bando M., Nakato R., Ishikawa S., Sato-Otsubo A., Nagae G., Nishimoto A., Haferlach C., Nowak D., Sato Y., Alpermann T., Nagasaki M., Shimamura T., Tanaka H., Chiba K., Yamamoto R., Yamaguchi T., Otsu M., Obara N., Sakata-Yanagimoto M., Nakamaki T., Ishiyama K., Nolte F., Hofmann W.-K., Miyawaki S., Chiba S., Mori H., Nakauchi H., Koeffler H.P., Aburatani H., Haferlach T., Shirahige K., Miyano S., Ogawa S.
Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms.
Nat. Genet. 45:1232-1237(2013)

PubMed=24368162; DOI=10.1016/j.exphem.2013.12.004
Sripayap P., Nagai T., Uesawa M., Kobayashi H., Tsukahara T., Ohmine K., Muroi K., Ozawa K.
Mechanisms of resistance to azacitidine in human leukemia cell lines.
Exp. Hematol. 42:294-306.e2(2014)

PubMed=25130606; DOI=10.1016/j.intimp.2014.08.002
Chanput W., Mes J.J., Wichers H.J.
THP-1 cell line: an in vitro cell model for immune modulation approach.
Int. Immunopharmacol. 23:37-45(2014)

PubMed=25984343; DOI=10.1038/sdata.2014.35; PMCID=PMC4432652
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G.-Z., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E.T., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H.-B., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Meyers B.H., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=29787063; DOI=10.1007/978-3-319-16104-4_14
Chanput W., Peters V., Wichers H.J.
THP-1 and U937 cells.
(In book chapter) The impact of food bioactives on health. In vitro and ex vivo models; Verhoeckx K., Cotter P., Lopez-Exposito I., Kleiveland C., Lea T., Mackie A., Requena T., Swiatecka D., Wichers H. (eds.); pp.147-159; Springer; Cham; Switzerland (2015)

PubMed=26421875; DOI=10.1089/ten.TEC.2015.0188
Yamazoe H., Hagihara Y., Kobayashi H.
Multicomponent coculture system of cancer cells and two types of stromal cells for in vitro evaluation of anticancer drugs.
Tissue Eng. Part C. Methods 22:20-29(2016)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28109323; DOI=10.1186/s13045-017-0396-0; PMCID=PMC5251306
Masetti R., Bertuccio S.N., Astolfi A., Chiarini F., Lonetti A., Indio V., De Luca M., Bandini J., Serravalle S., Franzoni M., Pigazzi M., Martelli A.M., Basso G., Locatelli F., Pession A.
Hh/Gli antagonist in acute myeloid leukemia with CBFA2T3-GLIS2 fusion gene.
J. Hematol. Oncol. 10:26.1-26.5(2017)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=28404994; DOI=10.1038/s41598-017-00828-y; PMCID=PMC5429802
Muller M.M., Lehmann R., Klassert T.E., Reifenstein S., Conrad T., Moore C., Kuhn A., Behnert A., Guthke R., Driesch D., Slevogt H.
Global analysis of glycoproteins identifies markers of endotoxin tolerant monocytes and GPR84 as a modulator of TNFalpha expression.
Sci. Rep. 7:838-838(2017)

PubMed=29169185; DOI=10.14573/altex.1607191
Kletting S., Barthold S., Repnik U., Griffiths G.W., Loretz B., Schneider-Daum N., de Souza Carvalho-Wodarz C., Lehr C.-M.
Co-culture of human alveolar epithelial (hAELVi) and macrophage (THP-1) cell lines.
ALTEX 35:211-222(2018)

PubMed=29901211; DOI=10.14573/altex.1710051
Edwards A., Roscoe L., Longmore C., Bailey F., Sim B., Treasure C.
Adaptation of the human Cell Line Activation Test (h-CLAT) to animal-product-free conditions.
ALTEX 35:477-488(2018)

PubMed=30285677; DOI=10.1186/s12885-018-4840-5; PMCID=PMC6167786
Tan K.-T., Ding L.-W., Sun Q.-Y., Lao Z.-T., Chien W., Ren X., Xiao J.-F., Loh X.-Y., Xu L., Lill M., Mayakonda A., Lin D.-C., Yang H.H., Koeffler H.P.
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
BMC Cancer 18:940.1-940.13(2018)

PubMed=30629668; DOI=10.1371/journal.pone.0210404; PMCID=PMC6328144
Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.
Screening human cell lines for viral infections applying RNA-Seq data analysis.
PLoS ONE 14:E0210404-E0210404(2019)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. 3rd, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646
Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M., MacLeod R.A.F., Nagel S., Steube K.G., Uphoff C.C., Drexler H.G.
The LL-100 panel: 100 cell lines for blood cancer studies.
Sci. Rep. 9:8218-8218(2019)

PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254
Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. 3rd, Kalocsay M., Jane-Valbuena J., Gelfand E.T., Schweppe D.K., Jedrychowski M.P., Golji J., Porter D.A., Rejtar T., Wang Y.K., Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A., Sellers W.R., Gygi S.P.
Quantitative proteomics of the Cancer Cell Line Encyclopedia.
Cell 180:387-402.e16(2020)

PubMed=32387766; DOI=10.1016/j.molimm.2020.04.008
Pandey K., Mifsud N.A., Lim Kam Sian T.C.C., Ayala R., Ternette N., Ramarathinam S.H., Purcell A.W.
In-depth mining of the immunopeptidome of an acute myeloid leukemia cell line using complementary ligand enrichment and data acquisition strategies.
Mol. Immunol. 123:7-17(2020)

PubMed=33389257; DOI=10.1007/s10096-020-04106-0; PMCID=PMC7778494
Wurtz N., Penant G., Jardot P., Duclos N., La Scola B.
Culture of SARS-CoV-2 in a panel of laboratory cell lines, permissivity, and differences in growth profile.
Eur. J. Clin. Microbiol. Infect. Dis. 40:477-484(2021)

PubMed=35373342; DOI=10.1002/ijc.34019
Kasai F., Hirayama N., Fukushima M., Kohara A., Nakamura Y.
THP-1 reference data: proposal of an in vitro branched evolution model for cancer cell lines.
Int. J. Cancer 151:463-472(2022)

PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
Pan-cancer proteomic map of 949 human cell lines.
Cancer Cell 40:835-849.e8(2022)

Cross-references
Cell line collections (Providers) Abcam; ab271147
Abcam; ab275477
Abcam; ab281894
AddexBio; C0003024/4956
ATCC; TIB-202
BCRC; 60430
BCRJ; 0234
BEI_Resources; ARP-9942
CCTCC; GDC0100
CLS; 300356
DSMZ; ACC-16
ECACC; 88081201
ICLC; HTL97014
IZSLER; BS TCL 138
JCRB; JCRB0112
JCRB; JCRB0112.1
KCB; KCB 200549YJ
KCLB; 40202
NCBI_Iran; C563
RCB; RCB1189
RCB; RCB3686
TKG; TKG 0267
Ubigene; YC-D011
Cell line databases/resources CLO; CLO_0009348
CLO; CLO_0050999
MCCL; MCC:0000461
CLDB; cl4513
CLDB; cl4514
CLDB; cl4515
CLDB; cl4517
cancercelllines; CVCL_0006
CCRID; 1101HUM-PUMC000057
CCRID; 1102HUM-NIFDC00058
CCRID; 3101HUMSCSP567
CCRID; 3101HUMTCHu57
CCRID; 4201HUM-CCTCC00100
Cell_Model_Passport; SIDM01172
Cosmic-CLP; 909771
DepMap; ACH-000146
DSMZCellDive; ACC-16
IGRhCellID; THP1
LINCS_HMS; 50861
LINCS_LDP; LCL-1072
Lonza; 134
Anatomy/cell type resources BTO; BTO:0001370
Biological sample resources BioSample; SAMN03470795
BioSample; SAMN03473256
BioSample; SAMN03473419
BioSample; SAMN10987847
ENCODE; ENCBS248PAQ
ENCODE; ENCBS443IYN
ENCODE; ENCBS461BPB
ENCODE; ENCBS615XLU
ENCODE; ENCBS913QYS
ENCODE; ENCBS980LBL
CRISP screens repositories BioGRID_ORCS_Cell_line; 220
Chemistry resources ChEMBL-Cells; CHEMBL3307574
ChEMBL-Targets; CHEMBL614245
GDSC; 909771
PharmacoDB; THP1_1593_2019
PubChem_Cell_line; CVCL_0006
Encyclopedic resources Wikidata; Q7670282
Experimental variables resources EFO; EFO_0001253
Gene expression databases ArrayExpress; E-MTAB-38
ArrayExpress; E-MTAB-783
ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
ArrayExpress; E-MTAB-7721
ArrayExpress; E-MTAB-7722
GEO; GSM236807
GEO; GSM236843
GEO; GSM482495
GEO; GSM838432
GEO; GSM838433
GEO; GSM887706
GEO; GSM888799
GEO; GSM1374962
GEO; GSM1446742
GEO; GSM1670543
GEO; GSM2141952
GEO; GSM2141956
GEO; GSM2141958
GEO; GSM2141959
GEO; GSM2141962
GEO; GSM2141968
GEO; GSM2141972
GEO; GSM2141974
GEO; GSM2141979
GEO; GSM2141986
GEO; GSM2141987
GEO; GSM2141993
GEO; GSM2141995
GEO; GSM2141998
GEO; GSM2141999
GEO; GSM2142000
GEO; GSM2142004
GEO; GSM2142005
GEO; GSM2142009
GEO; GSM2142011
GEO; GSM2142015
GEO; GSM2142016
GEO; GSM2142019
GEO; GSM2142021
GEO; GSM2142023
GEO; GSM2142024
GEO; GSM2142028
GEO; GSM2142029
GEO; GSM2142030
GEO; GSM2142031
GEO; GSM2142036
GEO; GSM2142037
GEO; GSM2142039
GEO; GSM2142048
GEO; GSM2142049
GEO; GSM2142052
GEO; GSM2142053
GEO; GSM2142055
GEO; GSM2142059
GEO; GSM2142060
Medical resources MeSH; D000074084
Polymorphism and mutation databases Cosmic; 717684
Cosmic; 724818
Cosmic; 787480
Cosmic; 909771
Cosmic; 919122
Cosmic; 924051
Cosmic; 947361
Cosmic; 975303
Cosmic; 991556
Cosmic; 996316
Cosmic; 998748
Cosmic; 1012124
Cosmic; 1037666
Cosmic; 1070694
Cosmic; 1078722
Cosmic; 1089517
Cosmic; 1150901
Cosmic; 1176587
Cosmic; 1181604
Cosmic; 1187864
Cosmic; 1197931
Cosmic; 1278779
Cosmic; 1281356
Cosmic; 1319551
Cosmic; 1476425
Cosmic; 1519163
Cosmic; 1524842
Cosmic; 1601064
Cosmic; 1604863
Cosmic; 2089655
Cosmic; 2131559
Cosmic; 2306241
Cosmic; 2392976
IARC_TP53; 2198
LiGeA; CCLE_181
Progenetix; CVCL_0006
Proteomic databases PRIDE; PRD000345
PRIDE; PXD000328
PRIDE; PXD000953
PRIDE; PXD004034
PRIDE; PXD008516
PRIDE; PXD011690
PRIDE; PXD015039
PRIDE; PXD030304
Sequence databases EGA; EGAS00001000610
EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update10-Sep-2024
Version number50