Cellosaurus THP1-Dual (CVCL_X599)
Cell line name | THP1-Dual | |||||||||||||||||||||||||||
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Accession | CVCL_X599 | |||||||||||||||||||||||||||
Resource Identification Initiative | To cite this cell line use: THP1-Dual (RRID:CVCL_X599) | |||||||||||||||||||||||||||
Comments | Population: Japanese. Characteristics: Stably expresses two reporter genes: SEAP (secreted ALPP) and the Lucia luciferase. In this cell line SEAP is under the control of an IFN-beta minimal promoter fused to 5 NF-kappaB binding sites and 3 C-Rel binding sites. The Lucia luciferase reporter gene is under the control of an ISG54 minimal promoter in conjunction with 5 IFN-stimulated response elements (ISRE) (InvivoGen=thpd-nfis). Genetic integration: Method=Transfection; Gene=HGNC; HGNC:439; ALPP. Genetic integration: Method=Transfection; Gene=UniProtKB; P33967; B.cereus Bsr. Genetic integration: Method=Transfection; Gene=UniProtKB; P17493; Streptoalloteichus hindustanus ble (BleoR). Genetic integration: Method=Transfection; Gene=Lucia luciferase (Note=Synthetic gene designed on natural secreted luciferase genes from marine copepods). Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. | |||||||||||||||||||||||||||
Sequence variations |
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Disease | Childhood acute monocytic leukemia (NCIt: C9163) Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514) | |||||||||||||||||||||||||||
Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) | |||||||||||||||||||||||||||
Hierarchy | Parent: CVCL_0006 (THP-1) Children:
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Sex of cell | Male | |||||||||||||||||||||||||||
Age at sampling | 1Y | |||||||||||||||||||||||||||
Category | Cancer cell line | |||||||||||||||||||||||||||
Cross-references | ||||||||||||||||||||||||||||
Cell line collections (Providers) | InvivoGen; thpd-nfis | |||||||||||||||||||||||||||
Cell line databases/resources | cancercelllines; CVCL_X599 | |||||||||||||||||||||||||||
Encyclopedic resources | Wikidata; Q54972368 | |||||||||||||||||||||||||||
Entry history | ||||||||||||||||||||||||||||
Entry creation | 05-Sep-2014 | |||||||||||||||||||||||||||
Last entry update | 10-Apr-2025 | |||||||||||||||||||||||||||
Version number | 18 |