ID   THP1-Dual
AC   CVCL_X599
DR   cancercelllines; CVCL_X599
DR   InvivoGen; thpd-nfis
DR   Wikidata; Q54972368
CC   Population: Japanese.
CC   Characteristics: Stably expresses two reporter genes: SEAP (secreted ALPP) and the Lucia luciferase. In this cell line SEAP is under the control of an IFN-beta minimal promoter fused to 5 NF-kappaB binding sites and 3 C-Rel binding sites. The Lucia luciferase reporter gene is under the control of an ISG54 minimal promoter in conjunction with 5 IFN-stimulated response elements (ISRE) (InvivoGen=thpd-nfis).
CC   Sequence variation: Gene fusion; HGNC; HGNC:2457; CSNK2A1 + HGNC; HGNC:13917; DDX39B; Name(s)=CSNK2A1-DDX39B (from parent cell line).
CC   Sequence variation: Gene fusion; HGNC; HGNC:7132; KMT2A + HGNC; HGNC:7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg174fs*3 (c.520_545del26); Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transfection; Gene=HGNC; HGNC:439; ALPP.
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P33967; Bacillus cereus Bsr.
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P17493; Streptoalloteichus hindustanus ble (BleoR).
CC   Genetic integration: Method=Transfection; Gene=Synthetic construct Lucia luciferase (Note=Synthetic gene designed on natural secreted luciferase genes from marine copepods).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C9163; Childhood acute monocytic leukemia
DI   ORDO; Orphanet_514; Acute monoblastic/monocytic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0006 ! THP-1
SX   Male
AG   1Y
CA   Cancer cell line
DT   Created: 05-09-14; Last updated: 14-08-25; Version: 19
CH   CVCL_E8FA ! THP1-Dual hTLR3
CH   CVCL_E8FB ! THP1-Dual hTLR7
CH   CVCL_E8FC ! THP1-Dual hTLR8
CH   CVCL_E8FD ! THP1-Dual hTLR9
CH   CVCL_A8AI ! THP1-Dual KO-cGAS
CH   CVCL_E8F4 ! THP1-Dual KO-DNase2
CH   CVCL_A8AU ! THP1-Dual KO-IFI16
CH   CVCL_A8AL ! THP1-Dual KO-IFNAR2
CH   CVCL_A8AZ ! THP1-Dual KO-IKKepsilon
CH   CVCL_E8F5 ! THP1-Dual KO-IRF1
CH   CVCL_A8AV ! THP1-Dual KO-IRF3
CH   CVCL_E8F6 ! THP1-Dual KO-IRF5
CH   CVCL_E8F7 ! THP1-Dual KO-IRF7
CH   CVCL_A8BA ! THP1-Dual KO-MAVS
CH   CVCL_A8BB ! THP1-Dual KO-MDA5
CH   CVCL_5J54 ! THP1-Dual KO-MyD
CH   CVCL_A8BC ! THP1-Dual KO-RIG-I
CH   CVCL_E8F8 ! THP1-Dual KO-SAMHD1
CH   CVCL_A8AH ! THP1-Dual KO-STING
CH   CVCL_A8AY ! THP1-Dual KO-TBK1
CH   CVCL_A8AW ! THP1-Dual KO-TLR2
CH   CVCL_A8AX ! THP1-Dual KO-TLR4
CH   CVCL_A8BW ! THP1-Dual KO-TLR8
CH   CVCL_A8AJ ! THP1-Dual KO-TREX1
CH   CVCL_A8AM ! THP1-Dual KO-TRIF
CH   CVCL_E8FF ! THP1-Dual MD2-CD14 KO-TLR4
CH   CVCL_E8FE ! THP1-Dual MD2-CD14-TLR4
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