Cellosaurus logo
expasy logo

Cellosaurus THP1-Dual KO-STING (CVCL_A8AH)

[Text version]
Cell line name THP1-Dual KO-STING
Accession CVCL_A8AH
Resource Identification Initiative To cite this cell line use: THP1-Dual KO-STING (RRID:CVCL_A8AH)
Comments Population: Japanese.
Characteristics: Stably expresses two reporter genes: SEAP (secreted ALPP) and the Lucia luciferase. In this cell line SEAP is under the control of an IFN-beta minimal promoter fused to 5 NF-kappaB binding sites and 3 C-Rel binding sites. The Lucia luciferase reporter gene is under the control of an ISG54 minimal promoter in conjunction with 5 IFN-stimulated response elements (ISRE).
Knockout cell: Method=Not specified; HGNC; 27962; STING1.
Transfected with: HGNC; 439; ALPP.
Transfected with: Lucia luciferase, a synthetic gene designed on natural secreted luciferase genes from marine copepods.
Transfected with: UniProtKB; P33967; B.cereus Bsr.
Transfected with: UniProtKB; P17493; Streptoalloteichus hindustanus ble (BleoR).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; 2457; CSNK2A1 + HGNC; 13917; DDX39B; Name(s)=CSNK2A1-DDX39B (from parent cell line).
  • Gene fusion; HGNC; 7132; KMT2A + HGNC; 7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg174fs*3 (c.520_545del26); Zygosity=Heterozygous (from parent cell line).
Disease Childhood acute monocytic leukemia (NCIt: C9163)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_X599 (THP1-Dual)
Sex of cell Male
Age at sampling 1Y
Category Cancer cell line
Web pages https://www.invivogen.com/thp1-dual-kosting
Cell line databases/resources cancercelllines; CVCL_A8AH
Encyclopedic resources Wikidata; Q107117071
Entry history
Entry creation20-May-2021
Last entry update05-Oct-2023
Version number7