Cellosaurus THP1-Dual KO-TRIF (CVCL_A8AM)
| Cell line name | THP1-Dual KO-TRIF |
|---|---|
| Accession | CVCL_A8AM |
| Resource Identification Initiative | To cite this cell line use: THP1-Dual KO-TRIF (RRID:CVCL_A8AM) |
| Comments | Population: Japanese. Characteristics: Stably expresses two reporter genes: SEAP (secreted ALPP) and the Lucia luciferase. In this cell line SEAP is under the control of an IFN-beta minimal promoter fused to 5 NF-kappaB binding sites and 3 C-Rel binding sites. The Lucia luciferase reporter gene is under the control of an ISG54 minimal promoter in conjunction with 5 IFN-stimulated response elements (ISRE) (InvivoGen=thpd-kotrif). Knockout cell: Method=Not specified; HGNC; HGNC:18348; TICAM1. Genetic integration: Method=Transfection; Gene=HGNC; HGNC:439; ALPP. Genetic integration: Method=Transfection; Gene=UniProtKB; P33967; Bacillus cereus Bsr. Genetic integration: Method=Transfection; Gene=UniProtKB; P17493; Streptoalloteichus hindustanus ble (BleoR). Genetic integration: Method=Transfection; Gene=Synthetic construct Lucia luciferase (Note=Synthetic gene designed on natural secreted luciferase genes from marine copepods). Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. |
| Sequence variations |
|
| Disease | Childhood acute monocytic leukemia (NCIt: C9163) Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514) |
| Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) |
| Hierarchy | Parent: CVCL_X599 (THP1-Dual) |
| Sex of cell | Male |
| Age at sampling | 1Y |
| Category | Cancer cell line |
| Cross-references | |
| Cell line collections (Providers) | InvivoGen; thpd-kotrif |
| Cell line databases/resources | cancercelllines; CVCL_A8AM |
| Encyclopedic resources | Wikidata; Q107117082 |
| Entry history | |
| Entry creation | 20-May-2021 |
| Last entry update | 14-Aug-2025 |
| Version number | 11 |