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Cellosaurus THP-1 NF-kb-Luc2 reporter (CVCL_XZ65)

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Cell line name THP-1 NF-kb-Luc2 reporter
Synonyms THP-1 NF-kb luciferase reporter
Accession CVCL_XZ65
Resource Identification Initiative To cite this cell line use: THP-1 NF-kb-Luc2 reporter (RRID:CVCL_XZ65)
Comments Population: Japanese.
Characteristics: The luciferase reporter gene is under the control of the NF-kappaB response element (KYinno=KC-1216).
Doubling time: ~48 hours (KYinno=KC-1216).
Genetic integration: Method=Transduction; Gene=UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
Genetic integration: Method=Transduction; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase (Note=With optimized codon usage for mammalian expression = Luc2).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; HGNC:2457; CSNK2A1 + HGNC; HGNC:13917; DDX39B; Name(s)=CSNK2A1-DDX39B (from parent cell line).
  • Gene fusion; HGNC; HGNC:7132; KMT2A + HGNC; HGNC:7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg174fs*3 (c.520_545del26); Zygosity=Heterozygous (from parent cell line).
Disease Childhood acute monocytic leukemia (NCIt: C9163)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0006 (THP-1)
Sex of cell Male
Age at sampling 1Y
Category Cancer cell line
Cross-references
Cell line collections (Providers) KYinno; KC-1216 - Discontinued
Cell line databases/resources cancercelllines; CVCL_XZ65
Encyclopedic resources Wikidata; Q98133244
Entry history
Entry creation19-Dec-2019
Last entry update14-Aug-2025
Version number13