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Cellosaurus A-THP-1 (CVCL_5115)

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Cell line name A-THP-1
Synonyms Activated-THP-1
Accession CVCL_5115
Resource Identification Initiative To cite this cell line use: A-THP-1 (RRID:CVCL_5115)
Comments Population: Japanese.
Characteristics: Enriched with adherent cells. Maintains an activated state without exogenous stimulation (PubMed=10223614).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; HGNC:2457; CSNK2A1 + HGNC; HGNC:13917; DDX39B; Name(s)=CSNK2A1-DDX39B (from parent cell line).
  • Gene fusion; HGNC; HGNC:7132; KMT2A + HGNC; HGNC:7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg174fs*3 (c.520_545del26); Zygosity=Heterozygous (from parent cell line).
Disease Childhood acute monocytic leukemia (NCIt: C9163)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0006 (THP-1)
Sex of cell Male
Age at sampling 1Y
Category Cancer cell line
STR profile Source(s): RCB=RCB2128; TKG=TKG 0296

Markers:
AmelogeninX,Y
CSF1PO11,13
D5S81811,12
D7S82010
D13S3178,13
D16S53911,12
TH018,9.3
TPOX8,11
vWA16,17

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Publications

PubMed=10223614; DOI=10.1620/tjem.186.99
Tsuyoshi Tominaga, Masanori Suzuki, Hisaaki Saeki, Seiki Matsuno, Takehiko Tachibana, Toshio Kudo;
Establishment of an activated macrophage cell line, A-THP-1, and its properties.
Tohoku J. Exp. Med. 186:99-119(1998)

Cross-references
Cell line collections (Providers) RCB; RCB2128
TKG; TKG 0296
Cell line databases/resources CLO; CLO_0050998
cancercelllines; CVCL_5115
Encyclopedic resources Wikidata; Q54606088
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number23