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Cellosaurus THP-1 NF-kappaB-eGFP (CVCL_E2QQ)

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Cell line name THP-1 NF-kappaB-eGFP
Accession CVCL_E2QQ
Resource Identification Initiative To cite this cell line use: THP-1 NF-kappaB-eGFP (RRID:CVCL_E2QQ)
Comments Population: Japanese.
Characteristics: Expresses eGFP under the control of the NF-kappaB response element (PubMed=28542462).
Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; HGNC:2457; CSNK2A1 + HGNC; HGNC:13917; DDX39B; Name(s)=CSNK2A1-DDX39B (from parent cell line).
  • Gene fusion; HGNC; HGNC:7132; KMT2A + HGNC; HGNC:7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg174fs*3 (c.520_545del26); Zygosity=Heterozygous (from parent cell line).
Disease Childhood acute monocytic leukemia (NCIt: C9163)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0006 (THP-1)
Children:
CVCL_E2QR (THP-1 TLR4-CD14 NFkappaB-eGFP)
Sex of cell Male
Age at sampling 1Y
Category Cancer cell line
STR profile Source(s): Millipore=SCC223

Markers:
AmelogeninX,Y
CSF1PO11,13
D3S135815,17
D5S81811,12
D7S82010
D8S117910,14
D13S31713
D16S53911,12
D18S5113,14
D21S1130,31.2
FGA24,25
Penta D10,12
Penta E11,15
TH018,9.3
TPOX8,11
vWA16

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Publications

PubMed=28542462; DOI=10.1371/journal.pone.0178220; PMCID=PMC5443541
Claire Battin, Annika Hennig, Patrick Mayrhofer, Renate Kunert, Gerhard J. Zlabinger, Peter Steinberger, Wolfgang Paster;
A human monocytic NF-kappaB fluorescent reporter cell line for detection of microbial contaminants in biological samples.
PLoS ONE 12:e0178220.1-e0178220.20(2017)

Cross-references
Cell line collections (Providers) Millipore; SCC223
Entry history
Entry creation10-Sep-2024
Last entry update19-Dec-2024
Version number2