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Cellosaurus THP-1-R (CVCL_C0YQ)

[Text version]
Cell line name THP-1-R
Accession CVCL_C0YQ
Resource Identification Initiative To cite this cell line use: THP-1-R (RRID:CVCL_C0YQ)
Comments Population: Japanese.
Characteristics: Cultured continuously for 26 months (PubMed=6949641).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; 2457; CSNK2A1 + HGNC; 13917; DDX39B; Name(s)=CSNK2A1-DDX39B (from parent cell line).
  • Gene fusion; HGNC; 7132; KMT2A + HGNC; 7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (from parent cell line).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg174fs*3 (c.520_545del26); Zygosity=Heterozygous (from parent cell line).
Disease Childhood acute monocytic leukemia (NCIt: C9163)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0006 (THP-1)
Sex of cell Male
Age at sampling 1Y
Category Cancer cell line

Tsuchiya S., Kobayashi Y., Goto Y., Okumura H., Nakae S., Konno T., Tada K.
Induction of maturation in cultured human monocytic leukemia cells by a phorbol diester.
Cancer Res. 42:1530-1536(1982)

PubMed=3476218; DOI=10.1247/csf.12.225
Hyodoh F.
Effects of retinoic acid on the differentiation of THP-1 cell lines containing aneuploid or diploid chromosomes.
Cell Struct. Funct. 12:225-242(1987)

Cell line databases/resources cancercelllines; CVCL_C0YQ
Encyclopedic resources Wikidata; Q114313121
Entry history
Entry creation22-Sep-2022
Last entry update05-Oct-2023
Version number5