Cellosaurus logo
expasy logo

Cellosaurus THP-1-R (CVCL_C0YQ)

[Text version]
Cell line name THP-1-R
Accession CVCL_C0YQ
Resource Identification Initiative To cite this cell line use: THP-1-R (RRID:CVCL_C0YQ)
Comments Population: Japanese.
Characteristics: Cultured continuously for 26 months (PubMed=6949641).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; HGNC:2457; CSNK2A1 + HGNC; HGNC:13917; DDX39B; Name(s)=CSNK2A1-DDX39B (from parent cell line).
  • Gene fusion; HGNC; HGNC:7132; KMT2A + HGNC; HGNC:7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg174fs*3 (c.520_545del26); Zygosity=Heterozygous (from parent cell line).
Disease Childhood acute monocytic leukemia (NCIt: C9163)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0006 (THP-1)
Sex of cell Male
Age at sampling 1Y
Category Cancer cell line
Publications

PubMed=6949641
Shigeru Tsuchiya, Yasuko Kobayashi, Yoichi Goto, Hidesada Okumura, Shingi Nakae, Tasuke Konno, Keiya Tada;
Induction of maturation in cultured human monocytic leukemia cells by a phorbol diester.
Cancer Res. 42:1530-1536(1982)

PubMed=3476218; DOI=10.1247/csf.12.225
Fuminori Hyodoh;
Effects of retinoic acid on the differentiation of THP-1 cell lines containing aneuploid or diploid chromosomes.
Cell Struct. Funct. 12:225-242(1987)

Cross-references
Cell line databases/resources cancercelllines; CVCL_C0YQ
Encyclopedic resources Wikidata; Q114313121
Entry history
Entry creation22-Sep-2022
Last entry update19-Dec-2024
Version number6