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Cellosaurus THP-1/AR (CVCL_WI26)

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Cell line name THP-1/AR
Synonyms TAR
Accession CVCL_WI26
Resource Identification Initiative To cite this cell line use: THP-1/AR (RRID:CVCL_WI26)
Comments Population: Japanese.
Selected for resistance to: ChEBI; CHEBI_2038; 5-azacytidine (5-azaC).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; HGNC:2457; CSNK2A1 + HGNC; HGNC:13917; DDX39B; Name(s)=CSNK2A1-DDX39B (from parent cell line).
  • Gene fusion; HGNC; HGNC:7132; KMT2A + HGNC; HGNC:7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg174fs*3 (c.520_545del26); Zygosity=Heterozygous (from parent cell line).
Disease Childhood acute monocytic leukemia (NCIt: C9163)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0006 (THP-1)
Sex of cell Male
Age at sampling 1Y
Category Cancer cell line
Publications

PubMed=24368162; DOI=10.1016/j.exphem.2013.12.004
Piyanuch Sripayap, Tadashi Nagai, Mitsuyo Uesawa, Hiroyuki Kobayashi, Tomonori Tsukahara, Ken Ohmine, Kazuo Muroi, Keiya Ozawa;
Mechanisms of resistance to azacitidine in human leukemia cell lines.
Exp. Hematol. 42:294-306.e2(2014)

Cross-references
Cell line databases/resources cancercelllines; CVCL_WI26
Encyclopedic resources Wikidata; Q98133247
Entry history
Entry creation24-May-2019
Last entry update19-Dec-2024
Version number10