Cellosaurus THP1-HMGB1-Lucia (CVCL_A8BE)
Cell line name | THP1-HMGB1-Lucia |
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Accession | CVCL_A8BE |
Resource Identification Initiative | To cite this cell line use: THP1-HMGB1-Lucia (RRID:CVCL_A8BE) |
Comments | Population: Japanese. Characteristics: Designed to monitor ferroptosis, a form of non-apoptotic cell death. Stably express an HMGB1::Lucia luciferase fusion protein in the cytoplasm, following ferroptosis activation, the cell membrane ruptures and HMGB1::Lucia is released in the extracellular milieu (InvivoGen=thp1-gb1lc). Genetic integration: Method=Transfection; Gene=HGNC; HGNC:4983; HMGB1. Genetic integration: Method=Transfection; Gene=UniProtKB; P17493; Streptoalloteichus hindustanus ble (BleoR). Genetic integration: Method=Transfection; Gene=Lucia luciferase (Note=Synthetic gene designed on natural secreted luciferase genes from marine copepods). Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. |
Sequence variations |
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Disease | Childhood acute monocytic leukemia (NCIt: C9163) Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514) |
Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) |
Hierarchy | Parent: CVCL_0006 (THP-1) |
Sex of cell | Male |
Age at sampling | 1Y |
Category | Cancer cell line |
Cross-references | |
Cell line collections (Providers) | InvivoGen; thp-gb1lc |
Cell line databases/resources | cancercelllines; CVCL_A8BE |
Encyclopedic resources | Wikidata; Q107117083 |
Entry history | |
Entry creation | 20-May-2021 |
Last entry update | 10-Apr-2025 |
Version number | 9 |