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Cellosaurus BPS Bioscience THP-1 ISRE-driven luciferase reporter (CVCL_F0PJ)

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Cell line name BPS Bioscience THP-1 ISRE-driven luciferase reporter
Synonyms IRF Reporter (Luc) - THP-1
Accession CVCL_F0PJ
Resource Identification Initiative To cite this cell line use: BPS Bioscience THP-1 ISRE-driven luciferase reporter (RRID:CVCL_F0PJ)
Comments Population: Japanese.
Characteristics: Expression of the luciferase reporter gene is under the control of A multimerized ISRE (Interferon Stimulated Response Element) located upstream of a minimal TATA promoter (BPS Bioscience=79858).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Photinus pyralis firefly-type luciferase.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; HGNC:2457; CSNK2A1 + HGNC; HGNC:13917; DDX39B; Name(s)=CSNK2A1-DDX39B (from parent cell line).
  • Gene fusion; HGNC; HGNC:7132; KMT2A + HGNC; HGNC:7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg174fs*3 (c.520_545del26); Zygosity=Heterozygous (from parent cell line).
Disease Childhood acute monocytic leukemia (NCIt: C9163)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0006 (THP-1)
Sex of cell Male
Age at sampling 1Y
Category Cancer cell line
Web pages Provider; BPS Bioscience; 79858; https://bpsbioscience.com/irf-reporter-luc-thp-1-cell-line-79858
Entry history
Entry creation14-Aug-2025
Last entry update14-Aug-2025
Version number1