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Cellosaurus BF24 (CVCL_X687)

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Cell line name BF24
Synonyms BF-24
Accession CVCL_X687
Resource Identification Initiative To cite this cell line use: BF24 (RRID:CVCL_X687)
Comments Population: Japanese.
Characteristics: Contains stably integrated, silent copies of the HIV-1 LTR promoter linked to the CAT gene (PubMed=2789383).
Virology: Sensitive indicator cell line for HIV-1 Tat. When infected by HIV-1, BF24 produces high levels of chloramphenicol acetyl transferase (CAT) (BEI_Resources=ARP-1296).
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P62577; Escherichia coli cat.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; HGNC:2457; CSNK2A1 + HGNC; HGNC:13917; DDX39B; Name(s)=CSNK2A1-DDX39B (from parent cell line).
  • Gene fusion; HGNC; HGNC:7132; KMT2A + HGNC; HGNC:7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg174fs*3 (c.520_545del26); Zygosity=Heterozygous (from parent cell line).
Disease Childhood acute monocytic leukemia (NCIt: C9163)
Acute monoblastic/monocytic leukemia (ORDO: Orphanet_514)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0006 (THP-1)
Sex of cell Male
Age at sampling 1Y
Category Cancer cell line
Publications

PubMed=2789383; DOI=10.1073/pnas.86.18.7200; PMCID=PMC298024
Stefan Schwartz, Barbara K. Felber, Eva-Maria Fenyo, George N. Pavlakis;
Rapidly and slowly replicating human immunodeficiency virus type 1 isolates can be distinguished according to target-cell tropism in T-cell and monocyte cell lines.
Proc. Natl. Acad. Sci. U.S.A. 86:7200-7203(1989)

Cross-references
Cell line collections (Providers) BEI_Resources; ARP-1296
Cell line databases/resources cancercelllines; CVCL_X687
Encyclopedic resources Wikidata; Q54796173
Entry history
Entry creation05-Sep-2014
Last entry update14-Aug-2025
Version number19